Epidemiological characteristics and risk factors of severe asthma in children: a single-center prospective cohort study [PDF]
, 2023 Objective·To explore the epidemiological characteristics of severe asthma in children and analyze the risk factors.Methods·A single-center prospective cohort study was conducted.
DAI Jiajia +7 more
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儿童下气道菌群多样性及其对支气管哮喘辅助性T细胞分化机制影响研究进展 [PDF]
, 2018 哮喘是由多种细胞(如嗜酸性粒细胞、肥大细胞、T淋巴细胞、中性粒细胞、气道上皮细胞等)和细胞组分参与的以慢性气道炎症和气道高反应性为特征的一种异质性疾病[1]。近年来哮喘发病率逐年攀升,据全球哮喘防治创议(GINA)委员会调查显示,全球约有3亿人受到哮喘困扰[2],世界卫生组织(WHO)预计至2025年全世界哮喘患者将会增至4亿人。研究发现,哮喘患者气道菌群在丰度及多样性等方面与正常人存在显著差异[3 ...
侯凌云, 吴谨准, 葛丹丹
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Clinical value of nitric oxide parameters in children with bronchial asthma [PDF]
, 2023 Exhaled nitric oxide （eNO）， as a marker of eosinophilic inflammation in the airway， has been widely utilized in the diagnosis and treatment of asthma. The fractional concentration of exhaled NO （FeNO） mainly reflects the degree of airway inflammation. By
Wei Ziqian, Yilimuguli Abudukeremu, Wu Baojing
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云南汉族人群Tim-3基因启动子区多态性与支气管哮喘的关联研究
Zhongguo shiyan zhenduanxue, 2021 目的阐明Tim-3基因多态性及其mRNA表达水平与云南汉族人群支气管哮喘发病之间的关联。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法和熔解曲线法,对180名云南汉族支气管哮喘患者和180名健康体检者Tim-3启动子区位点-1516G>T和-574T>G的基因多态性进行检测,同时采用逆转录-实时定量PCR(qRT-PCR)的方法检测和分析支气管哮喘组和健康体检组样本之间Tim-3mRNA的表达差异,并采用散射比浊测定法检测样本血浆中IgE的水平。结果 Tim-3启动子区多态性位点 ...
彭传梅 +7 more
doaj
Clinical study of exhaled nitric oxide in children with asthma and allergic rhinitis [PDF]
, 2023 Objective·To determine the levels of nasally exhaled nitric oxide (FnNO) combined with fractional concentration of exhaled nitric oxide (FeNO) in children with asthma (AS) complicated with allergic rhinitis (AR), and analyze the levels of FnNO and FeNO ...
DAI Yinfang +6 more
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呼出气一氧化氮测定与肺功能检测在哮喘病人诊断中的临床应用比较 [PDF]
Objective: Comparison the test result of exhaled nitric oxide (FeNO) level and pulmonary function for the patients with bronchial asthma. We will find the fast、efficient method for early diagnosis of bronchial asthma.
Wu, Xu-wei, Zhang, Yu-feng
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Current status and strategies of asthma questionnaire application in China [PDF]
, 2023 The prevalence of bronchial asthma in China is 4.2%, similar to other countries around the world, but the mortality rate of asthma in China is 36.7 /100 000, which is four times as high as that of Japan and seven times as that of the United States ...
BAO Wuping, LIN Yanmei, ZHANG Min
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TRPV1在小儿支气管哮喘中的表达以及与B7-H3和miR-29c相关性分析
Zhongguo shiyan zhenduanxue, 2022 目的 探究瞬时受体电位通道香草醛亚型-1(TRPV1)在小儿支气管哮喘中的表达以及与B7-H3和miR-29c相关性分析。方法 选取2019年4月—2020年4月收治的小儿支气管哮喘患儿172例作为研究对象，另选取同时段接受常规检查的健康儿童172例为健康志愿者。监测儿童肺功能水平变化，采用酶联免疫吸附法检测IgE、IFN-γ、EOS水平。分析TRPV1与B7-H3、miR-29c在小儿支气管哮喘中表达及相关性。结果 与健康志愿者相比，支气管哮喘儿童肺功能水平明显较低，具有统计学差异 ...
张志英 +5 more
doaj
Novel Developments in the Relationship of Gut Microbiota and Immune Regulation with Childhood Asthma [PDF]
, 2022 Bronchial asthma, commonly known as asthma, is a frequently seen chronic respiratory disease that seriously threatens human health. More than 300 million people have had asthma worldwide, and most of them are children. Epidemiological investigations have
CUI Tianyi, LIU Jiarui, LYU Bin, GAO Xiumei, ZHAO Xin
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Diagnostic value of fractional exhaled nitric oxide in predicting cough variant asthma in children with chronic cough: a systematic review and meta-analysis [PDF]
, 2023 Objective·To evaluate the values of fractional exhaled nitric oxide (FeNO) for the diagnosis of cough variant asthma (CVA) in children with chronic cough by systematic review and meta-analysis.Methods·PubMed, Embase, Cochrane Library, Web of Science ...
DANG Xiangyang +3 more
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