Results 71 to 80 of about 5,742 (154)
浙江大学学报. 医学版痛风石创面作为痛风终末期的严重并发症，由尿酸单钠盐（MSU）晶体沉积引发局部组织缺血、炎症反应及皮肤破溃形成，其病理机制涉及持续高尿酸血症状态下MSU结晶的生成、炎性包裹及痛风石增大对血运系统的机械压迫，最终导致慢性难愈性溃疡。治疗策略须综合全身代谢调控和局部创面修复。在药物治疗方面，以降尿酸治疗为核心，选用降尿酸药物（包括常规药物和新型靶向药物尿酸转运蛋白1抑制剂如AR882）将血尿酸水平维持在300 μmol/L以下，辅以口服抗炎药物（如非甾体抗炎药和糖皮质激素）减轻疼痛、缓解炎症 ...
何 国钰 +3 more
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合理饮食在胃癌术后治疗的作用与中医食疗的应用前景 [PDF]
, 2018 胃癌(gastric cancer, GC)术后放、化疗等治疗引起的毒副作用导致患者生活质量下降,出现癌症恶病质态。饮食辅助治疗能够显著地促进GC患者机体功能的恢复、缓解炎症反应、提高抗癌治疗耐受力,改善GC患者术后的生活质量、延长生存期。结合饮食在GC术后治疗的优势作用,本文分析了现代医学的元素营养饮食和传统中医食疗在GC术后的饮食辅助治疗作用,能够更好地了解中医传统食疗在缓解机体整体性功能失调的状态下的运用价值,促进中医食疗能够借鉴现代医学营养饮食的评估体系和扩大中医食疗在GC临床治疗程中的运用 ...
刘国彦, 刘磊, 洪裕玲
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Advances in immune checkpoint inhibitor therapy for breast cancer: research progress and future directions [PDF]
Breast cancer is the most prevalent malignancy among women worldwide. In recent years, immune checkpoint inhibitors (ICIs) have emerged as a promising therapeutic strategy across different molecular subtypes of breast cancer, demonstrating significant ...
ZENG Cheng, WANG Yuanyi, WANG Jiani, MA Fei
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Early diagnosis and personalized comprehensive treatment of nasopharyngeal carcinoma based on Epstein-Barr virus-specific markers [PDF]
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in East Asia and Southeast Asia, particularly prevalent in southern China.
CHEN Jie +3 more
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Platinum Resistance in Ovarian Cancer: Limitations of PFI Binary Classification and Potential Improvements [PDF]
Ovarian cancer is a common gynecologic malignancy. In clinical practice, recurrent ovarian cancer is mainly classified into two categories on the basis of platinum-free interval, platinum-resistant and platinum-sensitive, corresponding to different ...
Nan ZHANG, Wen DI, Xiaoyu LI
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口腔鳞状细胞癌中 Tip60（KAT5）的表达及其相关性分析 [PDF]
, 2020 【目的】探讨口腔鳞状细胞癌（OSCC）分化程度与Tip60（KAT5）表达相关性。【方法】选取口腔鳞状细胞共49例及癌旁正常口腔组织36例，采用免疫组化方法检测Tip60（KAT5）的表达状态。体外培养口腔鳞状细胞癌Cal27及UM1细胞株，Tip60（KAT5）抑制剂Nu9056处理Cal27及UM1细胞株后，MTT比色法检测Nu9056对Cal27及UM1细胞株增殖的影响。【结果】口腔鳞状细胞癌中Tip60（KAT5）的表达均明显高于癌旁正常组织中的表达（P=0.000）；随着组织学分化程度的降低 ...
廖德贵 +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】 探讨乳腺癌分子分型在表阿霉素联合多西紫杉醇方案(ET方案)化疗敏感性及预后方面的预测作用【方法】 对接受ET新辅助化疗方案治疗的244例乳腺癌患者进行回顾性分析依据免疫组化雌激素受体(ER)孕激素受体(PR)人表皮生长因子受体2(HER2)表达水平将乳腺癌分为LuminalHER-2+和Basal-like 3个分子亚型,分析3个分子亚型患者的病理疗效及远期生存的差别【结果】 244例患者中,167(68.4%)例为Luminal亚型,43(17.6%)例为HER2+亚型,34(13.9 ...
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Zhongguo shiyan zhenduanxue, 2017 Wnt是一类糖蛋白,其基因及产物参与了细胞功能的稳定和分化、胚胎发育、器官的形成[1]。相关研究还发现Wnt的调控参与细胞癌变和肿瘤的侵袭。所以Wnt细胞信号传导通路调控着机体许多生理及病理过程。最近,Wnt-11被证实在宫颈癌组织中表达上调,并与肿瘤的恶性程度及临床病理分期具有正向相关性[2]。本研究拟研究紫杉醇结合顺铂新辅助化疗对宫颈癌组织Wnt-11表达的影响,从而探讨其与宫颈癌发展及预后之间的联系。
李蜀凤, 刘宁, 王婷婷
doaj
Progress and future prospects in local and systemic treatment of early breast cancer [PDF]
Breast cancer is the most common malignant tumor in women. Early breast cancer refers to primary lesion localized in the breast and regional lymph nodes, and without distant metastasis. Treatment strategies include preoperative neoadjuvant therapy, local
LI Junjie
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Important research progress in clinical practice for early breast cancer in 2024 [PDF]
The diagnosis rate of early breast cancer has significantly increased with the proliferation of tumor screening and heightened health awareness. Clinical research, as the evidence base for guidelines and consensus, provides optimized treatment plans for ...
LI Xing, PENG Ziqi, YU Xinmiao, JIN Feng
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