Serum Levels of miR-19b and miR-146a as Prognostic Biomarkers for Non-Small Cell Lung Cancer [PDF]
, 2014 目的分析探讨了miRNAs在非小细胞肺癌（non-smallcelllungcancer，NSCLC）患者预后中发挥的作用。方法利用5例NSCLC癌组织及癌旁组织（其中3例为腺癌、2例为鳞状上皮细胞癌），采用能分析365个miRNA的TaqMan低密度芯片（lowdensityarray）含365个miRNA）确定NSCLC特异性的miRNA的表达谱。利用实时荧光定量PCR（quantitativereal-timePCR，qRT-PCR），通过对61对NSCLC癌组织及癌旁组织的方法进行检测 ...
吴朝辉
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Advances and Reflections on Neoadjuvant Therapy for Locally Advanced Thyroid Cancer [PDF]
The vast majority of thyroid cancers show a good prognosis. However, the treatment of locally advanced thyroid cancer presents a huge problem. The wide application of targeted and immunotherapy in neoadjuvant therapy for locally advanced thyroid cancer ...
CHEN Jian, FAN Qianyu, HUANG Qiuyi
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Zhongguo shiyan zhenduanxue, 2018 骨肉瘤(osteosarcoma,OS)是一种好发于儿童及青少年的原发性恶性骨肿瘤,其发病率约为4.4/100万,男性多于女性[1]。骨肉瘤好发于长骨干骺端,以股骨远端、胫骨近端及肱骨近端最为多见。骨肉瘤恶性程度高,具有较强的侵袭和转移特性,易发生肺转移,预后较差。随着新辅助化疗和放疗技术的广泛应用,骨肉瘤患者的5年生存率可达60-70%[2]。如何利用新理论 ...
刘书中, 周熹, 刘勇, 王以朋
doaj
Analysis of quality of life of rectal cancer patients after transanal total mesorectal excision and laparoscopic total mesorectal excision: a retrospective cohort study [PDF]
Background and purpose: There are few studies on the quality of life after transanal total mesorectal excision (TaTME) for rectal cancer, and there is a lack of evidence-based research.
CHEN Jiayu, LI Yue, CHEN Fan, LI Yuxue, FENG Shidong, HUANG Qi, LI Dawei, LIAO Zhiwei
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Analysis of pathological remission degree and influencing factors of radical surgery after neoadjuvant immunotherapy combined with chemotherapy in patients with locally advanced esophageal squamous cell carcinoma [PDF]
Background and purpose: Radical surgery after neoadjuvant immunotherapy combined with chemotherapy (nICT) in patients with locally advanced esophageal squamous cell carcinoma (LAESCC) has good efficacy and safety, and it can improve the patients ...
LIAO Ziyi, PENG Yang, ZENG Beilei, MA Yingying, ZENG Li, GAN Kelun, MA Daiyuan
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Zhongguo shiyan zhenduanxue, 2017 目的分析男性乳腺癌的临床特征、手术方式与远期效果,探讨术后生存质量及其影响因素。方法回顾分析我院1995年-2015年收治的45例男性乳腺癌患者的临床病例资料,入组患者均经病理确诊为乳腺癌、资料完整、随访齐全,分析患者的临床表现、病理特征、治疗方式、生活质量、远期疗效,探讨年龄、婚姻、文化程度、家庭收入、费用支付方式、疾病分期对术后生存质量的影响。结果 45例患者中97.78%患者以乳腺肿物为首发症状,70.45%肿物位于乳晕区,79.55 ...
陈达丰 +4 more
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Shanghai plan for early screening, diagnosis and treatment of colorectal cancer (2023 edition) [PDF]
Colorectal cancer is a common malignant tumor in China. At present, the incidence rate and the mortality rate of colorectal cancer in China are on the rise.
Colorectal Cancer Special Committee of Shanghai Anti-Cancer Association
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The preliminary research of miR-29b/c affects biological behavior in gastric carcinoma cell through regulating Mcl-1 [PDF]
, 2012 miRNAs是一类大小约22个核苷酸（nts）的内源性非编码小RNAs，通过与mRNA3´UTR完全或不完全互补结合降解靶mRNAs或抑制其翻译，参与细胞增殖、分化、代谢和凋亡等过程。前期研究发现miR-29c在胃癌中的表达量明显下降，并预测抗凋亡基因Mcl-1为miR-29的靶基因之一，其在胃癌组织中高表达并与miR-29c的表达呈反比相关。 本研究构建相关载体并应用荧光素酶报告基因技术进一步证实miR-29b/c与Mcl-1靶向作用关系。用Westernblot检测10例胃癌组织中Mcl-
马筱秋
core
胰十二指肠局部切除术后晚期直肠癌患者放化疗预后与MRI指标的关联研究
Zhongguo shiyan zhenduanxue, 2018 目的探讨胰十二指肠局部切除术后晚期直肠癌患者放化疗预后与MRI指标的相关性。方法使用TexRAD,采用T2加权对化疗前和化疗6周后MRI的过滤直方图技术进行纹理分析(TA)。在轴向图像上手动描绘包含肿瘤最大横截面积的感兴趣区域,并且过滤步骤在不同解剖尺度(精细,中等和粗糙)下提取特征,统计特征(平均强度,标准偏差,熵,偏度,峰度和正像素平均值)。Cox多元回归分析确定了包括组织学,放射学和组织学独立预测的总体生存期(OS),无病生存期(DFS)和无复发生存期(RFS)的单变量特征。结果 MPP(纹理细腻,
宋黎涛
doaj
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨Eya3表达与新辅助放化疗（neo-CRT）后食管癌（EC）肿瘤微环境中CD8+ T细胞浸润水平及患者预后的关系。方法收集50例neo-CRT联合手术治疗EC患者治疗前和术后的病理标本以及临床资料。通过免疫组化染色IHC）和多色免疫荧光染色等方法分析Eya3蛋白表达与患者术后病理特征、CD8+ T细胞浸润水平、无病生存期（DFS）和总生存期（OS）的关系。结果治疗前EC中基线Eya3低表达者病理完全缓解（pCR）率更高（P=0.001 8），相较于高表达者有更长的中位DFS（37.2个月vs ...
程菁菁, 郭丹玉, 钱东, 田界勇
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