Results 121 to 130 of about 29,642 (234)

Mechanisms of activity hepatic stellate cells induced myeloid-derived suppressor cells accumulation and migration [PDF]

open access: yes, 2015
原发性肝癌(hepatocellularcarcinoma,HCC)是全球第五大常见的恶性肿瘤,在肿瘤致死的病因中排名第三位。在全球,每年有超过50万人死于肝癌,且一半以上在中国。随着科学研究的发展,科研人员发现肝癌的发生发展不仅仅是病毒感染、环境因素、基因突变这些因素,肿瘤微环境对肿瘤的发生、发展、复发转移有着重要作用。肝脏是一个具有“免疫特赦”的脏器,肝癌微环境中的非实质细胞及其细胞因子是肝癌的免疫逃逸,复发转移的重要因素。 肝星状细胞(hepaticstellatecell,HSCs ...
许雅苹
core  

Climate stability drives multidimensional nestedness of amphibian assemblages in a Chinese sky island system

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The nested subset pattern (nestedness) has been widely used to explain species distributions in island and fragmented systems. Mountain sky islands serve as critical natural laboratories for understanding the evolutionary consequences of geographic isolation and climate
Caiwen Zhang   +5 more
wiley   +1 more source

制造技术与机床月刊

open access: yesJixie chuandong, 2015
<正>由中国机械工程学会和北京机床研究所主办,是机床及机械制造领域专业技术期刊,创刊于1951年,国际标准大16开本。属中文核心期刊,中国科技论文统计用刊、RCCSE中国核心学术期刊和《中国学术期刊文摘》摘录用期刊。报道国内外制造技术与机床方面的科技成果和经验,为提高我国机械制造业技术水平而服务。主要栏目有:每期技术主题、专题专访、国内外动态、综述、设计与研究、工艺与检测、汽车制造技术、模具技术、制造业信息化 ...
doaj  

Mechanistic study of TREM2 mutations in increasing the risk of neurodegenerative diseases [PDF]

open access: yes, 2016
2型髓系细胞触发受体(Triggeringreceptorexpressedonmyeliodcells2,TREM2)是中枢神经系统(centralnervoussystem,CNS)中主要表达于小胶质细胞表面并参与机体固有免疫的一种受体蛋白,与其接头蛋白酪氨酸激酶结合蛋白(DNAXactivatingproteinof12kDa,DAP12)形成TREM2/DAP12复合物,从而调节小胶质细胞中的炎症反应和吞噬功能。TREM2属于Ⅰ型跨膜蛋白,其胞外段经过蛋白酶切割后产生可溶形式TREM2 ...
王哲
core  

Mycorrhiza‐induced alterations in the spatial structure of stands in a subtropical forest

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Spatial aggregation patterns represent snapshots of ecological processes that occurred over an extensive period. Such processes can shape both the conspecific and the heterospecific spatial structure of plants across woody habitats.
Jingjing Xi   +6 more
wiley   +1 more source

电瓷工艺装备设计分析与研究(七)

open access: yesDianci bileiqi, 1994
电瓷工艺装备设计分析与研究(七)鲁延宾(西安电瓷研究所西安710077)第七章悬式绝缘子瓷件成型工装设计分析与研究悬式绝缘子的成型方法是:将用真空练泥机挤制的实心毛坯,经拉坯或削头,或墩制成凸形,装入铝制石膏模或带布套的铝模内,先预压后,再采用旋坯法...
鲁延宾
doaj  

MK2 inhibitor selectively reduces alkali burn-induced inflammation and neovascularization in cornea [PDF]

open access: yes, 2016
眼化学烧伤是一类常见的眼外伤疾病,特别是在发展中国家。与酸性烧伤相比,碱性烧伤更为常见。碱性物质可快速穿透眼前房,导致慢性炎症和角膜浑浊,从而导致严重且持久的视觉缺损。尽管角膜移植手术是一项有效的治疗方法,然而其成功与否取决于角膜的炎症和新生血管是否得到控制。尽管目前有许多用于治疗角膜炎症和新生血管的药物,然而由于其有一定的副作用或仅仅通过缓解症状而非从根本途径进行治疗,因此亟须从发病机制入手寻找新的治疗办法。 持久的角膜炎症与新生血管,不仅会导致永久的视觉缺失,还会使行角膜手术的时机推迟 ...
陈艳丰
core  

Parental care and bird embryonic metabolism: A comparison between uniparentally incubating Silver‐throated Tits and biparentally incubating Black‐throated Tits

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Studies have shown that organisms may adjust metabolic rates in response to thermal variability, highlighting metabolic plasticity as a key adaptive mechanism. Understanding the extent of metabolic plasticity of an organism is key to predicting its adaptation to climate
Qian Hu   +6 more
wiley   +1 more source

国家科委批准两项高压电器国家标准

open access: yesGaoya dianqi, 1966
1964年12月21日至24日,国家科委组织了水电部、一机部有关领导机关、制造、使用、科研等十六个单位,对高压电器研究所提出的“交流高压电器在长期工作时的发热 ...
叶德隆
doaj  

The phosphorylation of BAG3 by CDK5 and its roles in astrocytes [PDF]

open access: yes, 2016
细胞周期素依赖性蛋白激酶5(Cyclin-DependentKinase5,CDK5)是细胞周期蛋白依赖性丝氨酸/苏氨酸蛋白激酶家族中的一个成员,在神经系统的发育中发挥了至关重要的作用。CDK5的调节亚基P35、P39是神经系统特异性表达的蛋白,因此赋予了CDK5在神经系统中特异的激酶活性,使CDK5在调控神经递质传递,神经元凋亡等方面发挥了重要作用。对于CDK5的研究一直集中在对其新底物的发现和鉴定上,至今为止有40余个CDK5的底物被鉴定出来。作为脯氨酸依赖性蛋白激酶,CDK5可以特异磷酸化包含有 ...
张冠云
core  

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