nIL-33介导的巨噬细胞极化在口腔鳞状细胞癌中的作用及机制研究进展
Zhongguo shiyan zhenduanxue口腔鳞状细胞癌（OSCC）是世界范围内最常见的头颈部恶性肿瘤，OSCC的发生与口腔黏膜的癌前病变密切相关。巨噬细胞是黏膜免疫的重要参与者，通过调控不同表型的极化状态促进OSCC进展。核白细胞介素-33（nIL-33）通过调控细胞线粒体代谢重塑巨噬细胞极化。本文系统综述巨噬细胞与口腔鳞癌进展的关系，从细胞核-线粒体调控极化表型角度阐明巨噬细胞极化自我调控机制，以期为靶向巨噬细胞抗OSCC治疗提供思路和参考。
王娜 +5 more
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[Human umbilical cord mesenchymal stem cell grafting alleviates inflammatory response in type 1 diabetic mice by suppressing M1 macrophage polarization through Chi3l1]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLiu X, Xu Y, Sheng H, Liu H.
europepmc +1 more source
Shuitu Baochi Xuebao目的探究不同时间尺度下红河流域极端气候变化对植被的影响，对气候变化背景下流域生态系统保护和适应性管理具有重要意义。方法基于1982—2022年NDVI数据和38个气象站点的实测日气象数据，使用RClimDex模型计算16个极端气候指数，并运用趋势分析和相关分析探讨NDVI在年、季、月尺度下对极端气候事件的响应特征。结果1）红河流域NDVI年平均值为0.68，总体呈显著上升趋势，变化幅度为0.035/（10 a）（p<0.01、R2=0.78）；空间上呈“南高北低、西高东低”的分布格局。2 ...
王谦, 关颖慧, 刘玉国
doaj
High glucose induces pro-inflammatory polarization of macrophages by inhibiting immune-responsive gene 1 expression. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLuo W, Wang Y, Liu Y, Wang Y, Ai L.
europepmc +1 more source
[Layered double hydroxide-loaded si-NEAT1 regulates paclitaxel resistance and tumor-associated macrophage polarization in breast cancer by targeting miR-133b/PD-L1]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang Z +8 more
europepmc +1 more source
[Mechanisms of Neiyiting Decoction in Preventing Postoperative Recurrence of Endometriosis by Inhibiting Macrophage M1 Polarization Through the TREM1/TLR4/NF-κB Signaling Pathway]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLu L +9 more
europepmc +1 more source
Noggin alleviates neuropathic pain by regulating microglial polarization and remodeling iron homeostasis via a STAT3-dependent pathway. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanZhang W, Yang L, Zhang R.
europepmc +1 more source
[Ecliptasaponin A ameliorates DSS-induced colitis in mice by suppressing M1 macrophage polarization <i>via</i> inhibiting the JAK2/STAT3 pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoNiu M +8 more
europepmc +1 more source