【目的】 探讨左旋精氨酸(l-Arg)对大鼠中期肺动脉高压(PH)的防治作用及机理。【方法】 将18只雄性SD大鼠随机分为3组,对照组(C组,n = 6)。PH组(M组,n = 6)。l-Arg + PH组(L组,n = 6)。于M组和L组用野百合碱(MCT)一次腹膜腔注射诱导PH模型,L组每天进行腹膜腔注射l-Arg。 21 d 后用右心导管法测定右心室收缩压(RVSP);用化学比色法检测血浆中一氧化氮(NO)水平;用Hydroethidine进行肺灌注测量肺组织氧自由基(O2。誗-)的产量。【结果】
doaj
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