Results 21 to 30 of about 18,456 (162)
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 5, Page 621-630, November 2025.ABSTRACT Objectives To compare the maternal hemodynamics of Chinese women at low and at high risk for preterm pre‐eclampsia (PE) and assess the differences in hemodynamic parameters between high‐risk women with or without prophylactic aspirin. Methods This was a prospective longitudinal case–control study of 857 Chinese women with a singleton pregnancy
X. Wang +11 more
wiley +1 more source
Investigation of the Role and Mechanism of Rapamycin on Senile Osteoporosis via Osteocyte Autophagy [PDF]
, 2016 背景：老年性骨质疏松症患病人数逐年攀升，已成为严重的公共卫生问题。最新研究表明：骨细胞通过调节成骨细胞和破骨细胞的功能，从而主导骨重建。随着年龄增长，骨细胞凋亡增加，数目减少，导致骨代谢紊乱。细胞自噬是一种重要的生理机制，可以协助维持骨细胞活性。研究表明，因年龄增加而导致的骨细胞自噬功能障碍与老年性骨质疏松症的发病密切相关。因此，本课题以骨细胞自噬为切入点，选取经典的自噬诱导剂雷帕霉素，探究其对于老年性骨质疏松症的作用及可能机制。 方法：将52只24月龄SD大鼠随机分为雷帕霉素组和对照组 ...
罗德庆
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Veterinary Dermatology, Volume 36, Issue 5, Page 552-565, October 2025.Abstract Background Canine pyoderma is one of the most common presentations in small animal practice, frequently leading to antimicrobial prescribing. Objectives To provide clinicians with antimicrobial treatment guidelines for staphylococcal pyoderma, including those involving meticillin‐resistant staphylococci.
Anette Loeffler +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2017 糖尿病是一种全球性公共卫生挑战。在最近的国际糖尿病联盟发布的糖尿病地图中报告,世界上糖尿病患者流行人数估计达8.3%,约3.87亿,每7秒就有一人因糖尿病死亡[1]。2013年中华医学会糖尿病学分会公布糖尿病流行病学调查结果显示,我国18岁以上人群糖尿病患病率为9.
顾天菊, 王清
doaj
Cyclin Dependent Kinase 5 promotes invasion and metastasis of Hepatocellular Carcinoma [PDF]
, 2016 肝细胞癌（HepatocellularCarcinoma，HCC）在所有恶性肿瘤导致的死亡原因中占第三位，其发病率居恶性肿瘤的第六位。肝癌具有的高复发以及高转移，使肝癌愈后很差，而导致肝癌高复发和高转移的机制还不是很清楚。最近研究表明细胞周期蛋白激酶家族蛋白在上述调控过程中具有重要作用。 细胞周期素依赖蛋白激酶家族中的一个特殊蛋白：细胞周期素依赖蛋白激酶5（CyclinDependentKinase5，CDK5）引起了我们的注意，CDK5被认为主要在神经系统发挥作用。但是 ...
赵文兴
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Infant Mental Health Journal: Infancy and Early Childhood, Volume 46, Issue 5, Page 564-576, September 2025.Abstract Parental reflective functioning (PRF) is important in guiding parenting behavior. It is traditionally measured with interviews that are relatively time‐consuming. A self‐report measure of PRF, the Parental Reflective Functioning Questionnaire (PRFQ), has been developed but has not yet been extensively validated across different sociocultural ...
Marjo Flykt +4 more
wiley +1 more source
The establishment of Elispot-based neutralization assay for HCMV and its application in epidemiological study [PDF]
, 2013 人巨细胞病毒（humancytomegalovirus，HCMV）的感染在全球普遍存在。HCMV感染一般以潜伏状态存在，当机体免疫力低下时，则易发生再激发感染，引起严重甚至威胁生命的感染性疾病。在自然感染过程中，HCMV可感染包括淋巴细胞，上皮细胞以及内皮细胞在内的多种类型的细胞。HCMV体外培养体系的宿主细胞主要是上皮细胞及成纤维细胞。传统的基于细胞病变的TCID50以及空斑形成减少实验检测样本中和滴度的方法，存在周期长，操作繁杂，主观因素影响大的缺点，不适合大样本量的临床研究 ...
赵利利
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Implications of Tobacco Use on Pathogen‐Driven Diseases: A Public Health and Policy Perspective
World Medical &Health Policy, Volume 17, Issue 3, Page 468-474, September 2025.ABSTRACT The tobacco epidemic remains one of the most significant global public health challenges, responsible for over 8 million deaths annually, with a substantial portion occurring among non‐smokers exposed to second‐hand smoke. While cigarette smoking remains the most prevalent form of tobacco use worldwide, the rise of electronic nicotine delivery
Nadine Kabbani, James L. Olds
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2023 目的 了解长春市儿童下呼吸感染病原学特征及其分布规律，为本地区儿童下呼吸道感染的临床治疗提供的参考依据。方法 采用Realtime PCR方法对2018年12月至2019年11月份采集的73份儿童支气管肺泡灌洗液标本进行28种病原及亚型检测。结果 儿童下呼吸道感染中非典型病原体以支原体为主，病毒病原以呼吸道腺病毒、EB病毒、副流感病毒以主，细菌病原感染以流感嗜血杆菌为主。不同的病原体表现不同的流行期。结论 通过对长春市儿童下呼吸道感染进行多病原检测，掌握病原流行特点，不同季节的呼吸道病原谱不一致。
李静 +4 more
doaj
Development of ELISA kit for anti-Epstein-Barr virus antibody and its application in the diagnosis of nasopharyngeal carcinoma [PDF]
, 2015 鼻咽癌是中国南部和东南亚地区常见的一种肿瘤，鼻咽癌的发生、发展是EB病毒（Epstein-Barrvirus，EBV）持续感染、遗传因素和环境因素等共同作用的结果。研究表明，提高鼻咽癌的早期诊断率对于提高患者生存率、降低死亡率、改善患者生活质量、降低治疗费用都有重要意义。EBV特异性抗体作为鼻咽癌诊断标志物已有诸多报道并已经应用于临床，但其灵敏度和特异性均有待进一步提高。本研究基于EBV生活史中不同阶段的7种重组EBV抗原建立了相应血清抗体的ELISA检测试剂 ...
许亚蕊
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