Results 141 to 150 of about 47,871 (257)

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

open access: yesExperimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu   +7 more
wiley   +1 more source

The Preliminary Study On the Hulushan Site [PDF]

open access: yes, 2016
葫芦山遗址自1990年发掘以来,以其发现的大量黑衣陶以及古陶窑遗迹受到学术界的广泛关注。随着对闽江上游地区“黑衣陶”文化研究的深入,其文化内部差异研究、与闽江下游交流问题以及“黑衣陶”文化年代问题成为研究其文化内涵的主要内容。葫芦山遗址作为早年发掘的“黑衣陶”文化的重要遗址显得尤为关键,但遗憾的是其发掘资料一直未能发表,从而限制了学术界的深入研究。本文利用笔者参与的2014年葫芦山遗址发掘所获取的新材料,经过梳理,对葫芦山遗址的遗物特征、聚落形态、经济形态做了初步研究,并通过与闽江上下游典型遗址的对比 ...
陈震
core  

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu   +12 more
wiley   +1 more source

DNA methylation meets lineage tracing: History, recent progress, and future directions

open access: yesQuantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Lineage tracing techniques have been developed rapidly in the past decades by employing new genetic engineering tools. However, due to their invasive nature, these are difficult to apply to humans. Although endogenous DNA mutations can be used for in vivo lineage tracing in humans, their extremely low mutation rate presents substantial ...
Ruijiang Fu   +2 more
wiley   +1 more source

Cardiomyocyte‐Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING‐Mediated Inflammation

open access: yesThe FASEB Journal, Volume 40, Issue 3, 15 February 2026.
USP20 directly binds to STING and promotes the degradation of STING through the autophagy pathway by deubiquitinating p62 via its active site C154, thereby alleviating myocardial inflammation and improving ventricular remodeling and heart failure induced by diabetes. ABSTRACT Although extensive clinical and basic research has been conducted on diabetic
Yixin Zhou   +15 more
wiley   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao   +15 more
wiley   +1 more source

浙江余杭良渚遗址群出土玉器的无损分析研究 [PDF]

open access: bronze, 2011
福熹 干   +7 more
openalex   +1 more source

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