Results 91 to 100 of about 22,415 (183)
Veterinary Dermatology, EarlyView.Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes +8 more
wiley +1 more source
醋酸钠林格氏液对老年感染性休克手术麻醉患者血清电解质、乳酸和体温的影响
Zhongguo shiyan zhenduanxue, 2015 革兰阴性菌感染常可引起脓毒病综合征伴休克,感染灶中的微生物及其毒素等侵入血循环,影响机体各器官系统灌注。感染性休克患者,尤其是老年人,循环及体温调节能力明显下降,术前低代谢状态导致能量分解产热降低,极易发生组织细胞缺血缺氧、代谢紊乱、功能障碍,甚至多器官功能衰竭[1]。除积极控制感染外,应针对休克的病理生理给予补充血容量、纠正酸中毒,这些对于维护重要脏器的功能至关重要 ...
董愫 +4 more
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ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
Veterinary Dermatology, EarlyView.ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source
Function and mechanism of Repulsive Guidance Molecule RGMb/Dragon during Colorectal Cancer progression [PDF]
, 2016 结直肠癌是我国甚至全球范围内最常见的肿瘤之一，也是肿瘤相关死亡的主要原因之一。及时而有效的诊断是降低结直肠癌死亡率的重要措施。除了临床上常规的诊断及治疗方法外，人们也在不断致力于新型肿瘤标志物的研究，以进一步明确结直肠癌发生发展的机制。排斥导向分子(RGM)家族成员RGMb，又名Dragon，作为骨形态发生蛋白(Bonemorphogeneticprotein，BMP)通路的辅助受体，不但承载着胚胎发生、神经修复和肾脏正常生理功能，还与各种上皮来源肿瘤的发生发展密切相关。然而，RGMb ...
施颖
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Functional Ecology, Volume 40, Issue 2, Page 534-552, February 2026.Read the free Plain Language Summary for this article on the Journal blog. Abstract Non‐structural carbohydrates (NSC) are critical mediators of plant adaptation to fluctuating light environments. They are tightly coordinated with plant economic strategy, that is, leaf economics spectrum (LES) and root economics spectrum (RES).
Lulu Xie +6 more
wiley +1 more source
Experimental Study on the Effect of “CiJi regimen for curing cancers”on Gastrointestinal Function of Tumor Chemotherapy Model Mouse [PDF]
, 2015 目的：当前，肿瘤发病率有上升的趋势，严重威胁人们的身体健康。化疗是现代医学治疗肿瘤的主要手段之一。而化疗药物在许多患者身上出现了较明显的毒副反应，且其远期疗效不容乐观。患者复发率偏高、生存质量下降的问题较为突出。而且西医在化疗后的配套治疗上尚无令人满意的手段，大多在患者病情暂时缓解后采取“等待观察”的办法。由于化疗并不能完全消灭所有的肿瘤细胞，故而这一办法虽然使患者有一个“休养生息”的机会，同时也埋下了肿瘤“卷土重来”的隐患。因此，在化疗后的治疗环节上，选择合适的治疗方式和个性化的治疗方案是有意义的 ...
黄俊南
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Conservation Biology, Volume 40, Issue 1, February 2026.Abstract Urgency to save species from extinction has prompted increased investment in law enforcement in protected areas. To date, such law enforcement has largely focused on increasing costs and reducing opportunities for offending. However, these resource‐intensive approaches are not always effective and can contribute to conflict between people and ...
Freya A. V. St. John +3 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2015 内皮衍生微粒(EMP)在内皮细胞激活或凋亡时释放,由脂质双分子层和内容物组成,包含蛋白?核酸等物质?早期认为它是细胞垃圾?没有功能?但近十多年的研究发现EMP是反映内皮细胞功能和血管生物活性的重要物质,在血管活动?炎症?凝血等生理病理过程中发挥重要作用?本文就EMP的功能及组分?与内皮损伤修复?血管新生?心脑血管疾病的关系和作为标志物?信使传递的作用进行综述?
doaj
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 药物成瘾引起多脑区环路可塑变化，伴随相应的脑区功能改变和成瘾记忆形成。利用成瘾动物模型，结合电生理记录与环路操纵，我们证明脑可塑变化在药物成瘾中的重要作用。进一步地利用非侵入脑刺激技术结合同步电生理记录，我们给成瘾患者进行系统的皮层可塑测量，进行精准脑功能研究；并利用神经调控靶向干预对药物成瘾患者进行脑功能综合康复。这些研究结果提示脑可塑性在药物成瘾中的重要作用，为通过靶向干预脑功能调节脑可塑性治疗药物成瘾提供依据。
袁逖飞
doaj
The establishment of arsenite-transformed cells (TLECs) and the study on methylation of non-CpG island promoter repressing NQO1 expression in TLECs [PDF]
, 2016 摘 要 砷及其衍生物广泛分布自然环境并对人类健康构成危害。虽然流行病学研究已经证实长期的砷暴露能诱发多种癌症，但对砷致癌的确切机制目前远未被阐明，需要进一步深入地探索。砷诱导肿瘤形成是一个长期和复杂的过程，相关研究工作首先需要一个合适的细胞模型。为此，我们以低浓度亚砷酸钠长时间处理正常的大鼠肺上皮细胞系（LECs）诱导其转化，再通过一系列的指标实验验证，成功地建立砷转化细胞模型TLECs（Arsenite-transformedLECs），从而为下一步的研究奠定基础 ...
黄宁宇
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