Results 31 to 40 of about 25,036 (174)
The role of appoptosin in regulating oxidative stress and mitochondrial morphology [PDF]
, 2015 氧化压力是指细胞或体内氧自由基的含量超出抗氧化物及抗氧化酶类清除能力时对细胞或机体造成的氧化胁迫。氧化压力参与了包括炎症、衰老、心血管疾病、癌症、糖尿病、艾滋病、神经退行性疾病等多种疾病的发病过程。氧化压力通过多个下游信号通路对细胞造成胁迫，如JNK、Foxo等，但其中的具体参与蛋白仍有待于深入阐明。Appoptosin也被称为SLC25A38，是一种定位于线粒体内膜的转运蛋白，负责转入甘氨酸并转出D-氨基乙酰丙酸，进而调节血红素（heme）的合成 ...
张翠林
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From Clueless to Confident: How ChatGPT Transforms Academic Writing in Chinese as a Second Language
International Journal of Applied Linguistics, EarlyView.ABSTRACT Generative artificial intelligence (GenAI) has demonstrated its potential to enhance the quality of second‐language (L2) academic writing. This study used a qualitative approach comprising analysis of ChatGPT usage‐history screenshots, written assignments, and semi‐structured interview data on students’ use of GenAI in their L2 Chinese ...
Lanfang Sun +4 more
wiley +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT Second or foreign language (L2) speaking is a key aspect of L2 competence. While GenAI shows potential to address challenges in L2 speaking development, its role remains insufficiently understood. Self‐Determination Theory (SDT) could explain student language learning engagement. Therefore, this systematic review examines how GenAI affordances
Yanyan Catherine Lin +3 more
wiley +1 more source
Cuta deficiency causes memory impairments in middle-aged mice [PDF]
, 2016 阿尔茨海默症（AD）发病机制的核心是具有神经毒性的淀粉样蛋白（Aβ）在大脑中的过度堆积。Aβ是由淀粉样蛋白前体蛋白（APP）经过β-分泌酶（β-secretase或BACE1）和γ-分泌酶（γ-secretase）的顺序切割加工而成。CUTA是CutA二价阳离子耐受蛋白，参与调控乙酰胆碱酯酶在细胞内的聚合和转运。本实验室的前期研究发现CUTA和BACE1相互作用，并调节BACE1在细胞中的定位以及Aβ的生成。为了在体内研究CUTA的作用，本实验室构建了Cuta基因敲除的小鼠模型 ...
石准
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Journal of Sociolinguistics, EarlyView.ABSTRACT This study adopts a transnational raciolinguistic perspective to examine how Chinese international students (CISs) navigate language, race, and identity across borders and contexts. Based on semistructured interviews with 14 CISs, the study highlights that pre‐migration socialization in China influences how CISs perceive and interpret their ...
Gengqi Xiao, Hailing Wang, Jing Yu
wiley +1 more source
Huli yanjiu, 2003 目的 :观察全膝关节置换病人关节的功能恢复 ,康复护理对病人的心理与肢体运动功能的积极作用。方法 :经过临床实践 ,总结手术前后康复指导方法及实施措施。结果 :通过康复指导、心理护理、健康教育、功能锻炼 ,使病人提高了其活动功能 ,改善其生活自理能力。结论 :加强术前、术后指导 ,均可取得满意疗效。
冯娴, 景腊平, 张强
doaj
MLKL limits inflammatory responses through negatively regulating Toll-like receptor signaling pathway [PDF]
, 2015 炎症是机体清除有害刺激时做出的保护性反应，同时也是修复受损组织的一个过程。先天性免疫对微生物感染、组织损伤等造成的炎症起到了重要作用。但是，先天性免疫信号必须经过严格的调控，才能避免过于强烈的炎症反应对机体造成的不必要的伤害。Toll样受体在宿主识别病原体的入侵、激活炎症反应的过程中发挥了关键作用，因此，关于Toll样受体信号通路的负调控的研究显得尤为重要。本论文的研究发现，混合系蛋白激酶样结构域蛋白（mixedlineagekinasedomain-likeprotein，MLKL ...
庄秋宇
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The Inclusion Trade‐Off: Comparing the Design and Functionality of Collaborative Governance Forums
Policy Studies Journal, EarlyView.ABSTRACT Environmental challenges require collaboration across jurisdictions, often through forums or intermediary spaces for repeated interaction. A persistent forum design question concerns inclusion criteria, or which actors should be included.
Adam Wiechman +3 more
wiley +1 more source
Shuitu Baochi Xuebao, 2018 “南方红壤低山丘陵区水土流失综合治理”项目（2017YFC0505400）获得国家重点研发计划“典型脆弱生态修复与保护研究”专项支持。项目重点阐明区域水土流失演变规律及关键驱动因子，以生态功能提升与生产功能优化为核心，研发集成地表径流调控、土壤肥力提升、植被可持续恢复和景观结构优化为一体的水土流失治理技术体系，形成生态服务功能提升与民生改善的区域水土流失综合治理模式，为红壤低山丘陵区水土流失治理提供科技支撑。
史志华 +5 more
doaj
, 2010 窖蛋白-1(Cav-1)是胞膜窖的主要结构蛋白,可与多种信号分子相互作用,调节细胞的增殖、分化和凋亡,其异常表达与多种人体疾病的发生和发展密切相关,而在斑马鱼发育中的功能尚不很清楚。研究克隆出斑马鱼窖蛋白-1基因两个亚型的全长cDNA,与其他物种窖蛋白-1的氨基酸序列进行比较,发现该蛋白在脊椎动物中非常保守。利用逆转录多聚酶链反应检测发现,在斑马鱼多个成年组织中窖蛋白-1的两个亚型均有转录表达。利用胚胎整体原位杂交检测组织或器官特异基因的时空表达变化发现,过表达或利用Morpholino反义寡聚核苷酸(
厉洁 +4 more
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