Results 31 to 40 of about 25,301 (167)
The role of E3 ubiquitin ligase Smurf1 in the activation of AKT [PDF]
, 2015 作为一个既汇聚多种上游信号，同时又作用于多个下游效应分子的中心代谢调控分子，AKT对于细胞行使正常生物学功能及其调控，以及对于大量癌症的发生都具有不可或缺的作用。正常情况下，AKT活性的有无及强弱被严格控制以使其能够适度的压制细胞凋亡、刺激细胞增长和增值。然而在肿瘤环境中，AKT的过度活化现象被频繁发现于绝大部分肿瘤细胞，几乎所有人类癌症细胞都存在AKT过活现象。由于在正常生理及癌症环境中都起到如此重要的作用，大量研究专注于AKT的活化机制及其过度活化的诱因 ...
范宇希
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Taxonomic and functional diversity of urban bees of the world
Conservation Biology, EarlyView.Abstract Bees play a pivotal role in terrestrial environments. Urbanization can affect these organisms and the ecosystem services they provide. However, knowledge of the global diversity of urban bees is limited. Thus, we summarized data on urban bee species identities and occurrences; compared distributions of all bees with those found in urban ...
João C. F. Cardoso +10 more
wiley +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT Second or foreign language (L2) speaking is a key aspect of L2 competence. While GenAI shows potential to address challenges in L2 speaking development, its role remains insufficiently understood. Self‐Determination Theory (SDT) could explain student language learning engagement. Therefore, this systematic review examines how GenAI affordances
Yanyan Catherine Lin +3 more
wiley +1 more source
MLKL limits inflammatory responses through negatively regulating Toll-like receptor signaling pathway [PDF]
, 2015 炎症是机体清除有害刺激时做出的保护性反应，同时也是修复受损组织的一个过程。先天性免疫对微生物感染、组织损伤等造成的炎症起到了重要作用。但是，先天性免疫信号必须经过严格的调控，才能避免过于强烈的炎症反应对机体造成的不必要的伤害。Toll样受体在宿主识别病原体的入侵、激活炎症反应的过程中发挥了关键作用，因此，关于Toll样受体信号通路的负调控的研究显得尤为重要。本论文的研究发现，混合系蛋白激酶样结构域蛋白（mixedlineagekinasedomain-likeprotein，MLKL ...
庄秋宇
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Journal of Sociolinguistics, EarlyView.ABSTRACT This study adopts a transnational raciolinguistic perspective to examine how Chinese international students (CISs) navigate language, race, and identity across borders and contexts. Based on semistructured interviews with 14 CISs, the study highlights that pre‐migration socialization in China influences how CISs perceive and interpret their ...
Gengqi Xiao, Hailing Wang, Jing Yu
wiley +1 more source
Huli yanjiu, 2003 目的 :观察全膝关节置换病人关节的功能恢复 ,康复护理对病人的心理与肢体运动功能的积极作用。方法 :经过临床实践 ,总结手术前后康复指导方法及实施措施。结果 :通过康复指导、心理护理、健康教育、功能锻炼 ,使病人提高了其活动功能 ,改善其生活自理能力。结论 :加强术前、术后指导 ,均可取得满意疗效。
冯娴, 景腊平, 张强
doaj
Cuta deficiency causes memory impairments in middle-aged mice [PDF]
, 2016 阿尔茨海默症（AD）发病机制的核心是具有神经毒性的淀粉样蛋白（Aβ）在大脑中的过度堆积。Aβ是由淀粉样蛋白前体蛋白（APP）经过β-分泌酶（β-secretase或BACE1）和γ-分泌酶（γ-secretase）的顺序切割加工而成。CUTA是CutA二价阳离子耐受蛋白，参与调控乙酰胆碱酯酶在细胞内的聚合和转运。本实验室的前期研究发现CUTA和BACE1相互作用，并调节BACE1在细胞中的定位以及Aβ的生成。为了在体内研究CUTA的作用，本实验室构建了Cuta基因敲除的小鼠模型 ...
石准
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The underappreciated roles of fog and dew on vegetation and biocrusts
New Phytologist, EarlyView.Summary Fog and dew represent minor components of ecosystem water budgets in most ecosystems. However, fog and dew can play an essential role in ecosystem dynamics and are particularly important for water‐limited systems. In addition to serving as direct water inputs, fog and dew can influence microclimate and water redistribution, thereby promoting ...
Lixin Wang, Yue Li, Mengyun Sun, Na Qiao
wiley +1 more source
Shuitu Baochi Xuebao, 2018 “南方红壤低山丘陵区水土流失综合治理”项目（2017YFC0505400）获得国家重点研发计划“典型脆弱生态修复与保护研究”专项支持。项目重点阐明区域水土流失演变规律及关键驱动因子，以生态功能提升与生产功能优化为核心，研发集成地表径流调控、土壤肥力提升、植被可持续恢复和景观结构优化为一体的水土流失治理技术体系，形成生态服务功能提升与民生改善的区域水土流失综合治理模式，为红壤低山丘陵区水土流失治理提供科技支撑。
史志华 +5 more
doaj
The synthesis of triazole derivatives on mushroom tyrosinase and their mechanisms [PDF]
, 2016 酪氨酸酶广泛的存在于各生物体内，其产物多巴醌能与氨基酸或者蛋白质聚合黑色素，该酶是合成黑色素的关键酶。然而黑色素的过量合成会引起雀斑、黄褐斑、老年斑等色素沉积性皮肤病，此外研究表明，酪氨酸酶还与帕金森综合症、昆虫蜕皮、果蔬褐变有密切关系。因此，控制酪氨酸酶活性的研究在农业、制药业及化妆品行业有重要开发价值。 4-氨基-3-肼基-5-巯基-1，2，4-三唑（AHMT）为五元氮杂环，是酰胺键的电子等排物，也具有潜在的配位键，而苯甲醛类衍生物为酪氨酸酶底物的类似物，可以竞争性抑制酶失活性 ...
喻枫
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