The Molecular Mechanisms and Biological Functions on Regulation of p53 Transcriptional Activity by Ubiquitin-Specific Protease USP4 through Histone Deacetylase HDAC2 [PDF]
, 2013 泛素-蛋白酶体通路是蛋白质选择性降解中一项非常重要的机制，蛋白酶体识别多聚泛素化蛋白质，并将其降解。去泛素化酶主要作用是切断泛素链与底物蛋白之间的连接，使蛋白底物重新进入细胞内蛋白调节的循环中。蛋白质乙酰化与去乙酰化是可逆的翻译后修饰过程：乙酰化基团在蛋白乙酰化酶的催化作用下添加到底物蛋白Lys上而蛋白质去乙酰化酶则介导从底物蛋白Lys残基上去除乙酰化基团。已有的研究表明，组蛋白去乙酰化酶HDACs在基因转录调控中起重要作用 ...
郝穹予
core
乳头状甲状腺癌中KISS-1、VEGF-C的表达及与临床病理的关系
Zhongguo shiyan zhenduanxue, 2015 目的研究乳头状甲状腺癌中KISS-1、VEGF-C的表达及与临床病理的关系。方法选取2012年7月到2013年7月我院收集的乳头状甲状腺癌病理标本60例（研究组）,另选取正常甲状腺组织30例（对照组）,应用免疫组织化学SP法测定KISS-1、VEGF-C在两组中的表达情况,并分析其与临床病理的关系。结果研究组KISS-1阳性者显著少于对照组,VEGF-C阳性者显著多于对照组,两组比较差异具有统计学意义 ...
李学庆 +5 more
doaj
Advances and Reflections on Neoadjuvant Therapy for Locally Advanced Thyroid Cancer [PDF]
The vast majority of thyroid cancers show a good prognosis. However, the treatment of locally advanced thyroid cancer presents a huge problem. The wide application of targeted and immunotherapy in neoadjuvant therapy for locally advanced thyroid cancer ...
CHEN Jian, FAN Qianyu, HUANG Qiuyi
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PI3K-AKT-mTOR信号通路在分化型甲状腺癌演变过程中的研究现状
Zhongguo shiyan zhenduanxue, 2015 甲状腺癌的发病率在世界范围内呈上升趋势,近十年来发病人数急剧增加[1]。甲状腺腺瘤起源于甲状腺滤泡细胞,具有过度增殖的属性[2],其中来自甲状腺滤泡细胞甲状腺癌占大多数,其中以甲状腺乳头状癌（PTC）最为常见,占所有甲状腺癌的80%。而目前临床上甲状腺癌的治疗方法大致分为手术治疗、TSH抑制治疗、放射性碘治疗、分子靶向治疗4种。本文主要讨论PI3K-AKT ...
刘杨, 刘晓莉, 孙辉
doaj
Clinical features of multifocal papillary thyroid carcinoma and risk factors of cervical metastatic lymph nodes. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2022 Ni Y +5 more
europepmc +1 more source
The role of diagnostic whole body scan in decision-making of 131I treatment for differentiated thyroid cancer [PDF]
Background and purpose: As one of the first-line treatment methods for differentiated thyroid cancer (DTC), 131I treatment is an important therapeutic approach for most patients with medium-high recurrence risk DTC after total or near-total thyroidectomy.
JIANG Xiaotong, LIU Jinchuan, ZHANG Yingqiang, WANG Tong, GUO Ning, SUN Yuqing, SHI Cong, YAN Bing, LIN Yansong
core +1 more source
Endoscopic thyroidectomy using gasless axillary approach for low-risk papillary thyroid carcinoma. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2021 Xu S +6 more
europepmc +1 more source
Research progress on the role of glutamine metabolism-related proteins in tumor metastasis [PDF]
Tumor metastasis is closely related to high mortality rate of cancer. It is well known that glutamine plays an important role in the malignant progression of cancer.
LIU Xuerou, YANG Yumei, ZHAO Qian, RONG Xiangyu, LIU Wei, ZHENG Ruijie, PANG Jinlong, LI Xian, LI Shanshan
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血清TSH、sTg表达与甲状腺乳头状癌患者超声引导下射频消融预后的关系研究
Zhongguo shiyan zhenduanxue目的 观察血清刺激性甲状腺球蛋白(sTg)、促甲状腺激素(TSH)表达与甲状腺乳头状癌患者超声引导下射频消融预后的关系。方法 回顾性分析2022年1月至2023年1月在河北省衡水市第二人民医院接受超声引导下射频消融治疗且预后较好的30例甲状腺乳头状癌患者纳入预后良好组，同期经超声引导下射频消融治疗但出现转移、复发的30例甲状腺乳头状癌患者纳入预后不良组，对比2组患者治疗前空腹血清中sTg和TSH水平，分析血清中sTg和TSH水平与超声引导下射频消融治疗预后的关系。结果 ...
孟芳, 沈玉琴
doaj
, 2020 桥本甲状腺炎（Hashimoto′s thyroiditis,HT）的病理和超声表现复杂,HT背景下的甲状腺乳头状癌（papillary thyroid carcinoma,PTC）鉴别诊断有难度。超声特征上微钙化是诊断PTC的危险因素,而粗钙化一般提示为良性病变,但PTC合并HT发生的钙化现象多见且类型多样化,粗钙化的发生率可能高于微钙化,各类钙化皆提示有恶性风险。钙化可能与癌症发生、侵袭和转移相关,HT背景下的钙化现象需引起警惕 ...
刘荣耀 +4 more
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