Design, synthesis of diaryl ether tyrosine kinases inhibitior and study of their antiaumor activities [PDF]
, 2014 肿瘤是机体在各种致癌因子作用下，细胞内遗传物质发生改变，进而导致基 因表达失常，细胞异常增殖的新生物。以一些与肿瘤细胞分化增殖相关的细胞信 号转导通路的关键酶作为药物筛选靶点，发现选择性作用于特定靶点的高效、低 毒、特异性强的新型抗癌药物——酪氨酸激酶抑制剂已成为当今抗肿瘤药物研究 开发的重要方向。 本文结合计算机辅助设计和文献分析，以二芳醚为基础利用生物电子等排体 理论用酰胺结构代替脲，设计合成了五个系列的二芳醚酰胺类化合物，并对这些 化合物进行抗肿瘤活性筛选。本文分别选取HepG2、A549及HT ...
杨少梅
core
ARMS法甲状腺乳头状癌BRAF基因检测252例临床病理分析
Zhongguo shiyan zhenduanxue, 2016 甲状腺乳头状癌（PTC）占所有甲状腺恶性肿瘤的85%-90%[1],是甲状腺癌中最常见的病理类型。众所周知,甲状腺癌的发病率逐年增加。鉴于日益增多的甲状腺癌,其中绝大多数是亚临床的,迫切需要找出一种可靠的术前分层方法（依据患者复发和死亡风险）来确定是否进行手术、手术的范围以及术后辅助治疗的需要。目前研究表明[2,3],BRAF ...
包亮, 王贵民
doaj
[Correlation of conventional ultrasound features and related factors with BRAFV600E gene mutation in papillary thyroid carcinoma]. [PDF]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2021 Lv Y +6 more
europepmc +1 more source
SFXN3 expression in head and neck squamous cell carcinoma and its effect on cell proliferation [PDF]
Objective·To analyze the expression of mitochondrial related gene SFXN3 (sideroflexin 3) in head and neck squamous cell carcinoma (HNSCC) and its effect on cell proliferation.Methods·Mitochondrial related genes and TCGA-HNSCC dataset were obtained from ...
AN Junyi +5 more
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Zhongguo shiyan zhenduanxue, 2015 甲状腺髓样癌(MTC)与乳头状癌和滤泡癌不同,是起源于甲状腺滤泡旁细胞(C细胞)特殊的恶性肿瘤。临床较少见,占所有甲状腺癌5%-10%[1]。又由于MTC细胞形态多样,明确诊断比较困难。本研究对14例经组织学证实甲状腺髓样癌的细胞学形态进行分析,旨在提高诊断MTC准确性。1材料与方法1.1材料收集我院2012年5月 ...
张文杰, 闻春艳, 孙大菊
doaj
Zhongguo shiyan zhenduanxue, 2004 目的 探讨碱性成纤维细胞生长因子 （basicfibroblastgrowthfactor ,bFGF）在甲状腺癌中的表达及临床意义。方法 用免疫组织化学方法检测 10 4例甲状腺癌和 10例正常甲状腺组织中bFGF的表达情况 ,并分析其与相关临床病理因素的关系。结果 bFGF表达阳性率在甲状腺癌组显著高于正常甲状腺组 ,未分化癌组显著高于乳头状癌组 ,有转移者bFGF阳性率高于无转移者。结论 bFGF与肿瘤病理类型、浸润转移相关 ,可作为预测肿瘤转移潜能的指标。
田晓丰 +5 more
doaj
Current status and prospect of diagnosis and treatment of bone metastasis of thyroid cancer [PDF]
For differentiated thyroid cancer (DTC), which accounts for over 90% of cases and usually has a good prognosis, bone metastasis is not only the main threat to patients’ survival and quality of life, but also a difficult problem that needs to be solved ...
ZHAO Yihan, LI Ruochen, LIN Yansong
core +1 more source
[Correlation between conventional ultrasound features and BRAFV600E gene mutation and central lymph node metastasis in thyroid papillary carcinoma]. [PDF]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2022 Zhang J +6 more
europepmc +1 more source
Zhongguo shiyan zhenduanxue, 2014 目的探讨术前运用细针穿刺甲状腺结节行细胞学检查,结合免疫细胞化学分析,进一步提高对甲状腺乳头状病变术前诊断的准确率。方法回顾分析本院2008年2月至2009年4月收治的术前细针穿刺甲状腺乳头状病变62例。作常规细胞学涂片及液基薄层细胞学涂片,同时结合免疫细胞化学检查进行Galectin-3,细胞角蛋白19和HMBE-1等标记的测定和分析,与手术后组织病理结果作比较。结果对照术后组织病理,32例为癌性乳头,30例为良性乳头,细胞学诊断准确率为83.9%（良性乳头中有6例 ...
吴丽华
doaj
Application and prospect of targeted therapy and immunotherapy in radioiodine-refractory differentiated thyroid cancer [PDF]
Thyroid cancer (TC) is a common malignant tumor of the endocrine system, with differentiated TC (DTC) accounting for more than 90%. Most patients usually have a good overall prognosis after receiving radioactive iodine (RAI) treatment, however some ...
LIN Qiuyu, WANG Yuxin, LIN Chenghe
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