Results 91 to 100 of about 1,673 (154)

[Association of Body Mass Index and Weight Gain With Obesity-Related Breast Cancer Risk Biomarkers in Adult Chinese Women]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban, 2023
Zhou M, Hao Y, Fu P, Zhao X, Yan L, Li X, Li J.   +6 more
europepmc   +1 more source

青春期启动与肥胖相关的研究进展

Zhongguo shiyan zhenduanxue
青春期发育启动年龄呈现提前的趋势，性早熟与超重、肥胖的患病率之间呈现平行上升趋势。青春期启动提前与肥胖存在流行病学关联和发病机制的关联，其关联机制是当前关注热点之一。研究表明，肥胖与青春期启动可通过神经内分泌、肠道微生物及其代谢物、遗传等多方面相互影响，具体机制可涉及瘦素、脂联素、胰岛素及其受体、高雄激素血症、性早熟相关基因、母体及孕期因素和肠道微生物群等。该文基于上述多种因素概述了青春期启动与肥胖的相关研究进展，为进一步探讨性早熟、肥胖等相关疾病的发生机制及防治提供参考。
杨丹
doaj  

雌性大鼠性早熟对糖脂代谢的影响

Zhongshan Daxue xuebao. Yixue kexue ban
目的探究雌性大鼠性早熟对糖代谢和脂代谢的影响。方法将60只两天龄的雌性大鼠随机分为性早熟组和正常组两组，分别在5天龄时给予达那唑（300 μg/只）或溶剂大豆油进行皮下注射，从21天龄起每天观察大鼠的阴道开口状况。建模成功的两组按照阴道开口顺序分别于阴道开口后3 d、7周龄和12周龄进行处死，处死前空腹12 h。方法测量麻醉后的体重和鼻肛长，通过酶联免疫吸附试验测量葡萄糖、胰岛素、血脂、雌二醇、瘦素和脂联素的浓度，病理切片观察肾周脂肪、子宫和卵巢的变化。结果通过正常组和早熟组两组3个时间点对比 ...
林小雅, 黄宝江, 张军, 郭松, 马华梅, 李燕虹, 杜敏联, 陈秋莉   +7 more
doaj  

ANGPTL4基因在3T3-L1前脂肪细胞诱导分化过程中表达水平的变化

Zhongguo shiyan zhenduanxue, 2009
目的观察血管生成素样蛋白-4（Angiopoietin-like protein 4,ANGPTL4）基因在3T3-L1前脂肪细胞诱导分化过程中表达水平的变化,探讨ANGPTL4基因与脂肪细胞分化的关系。方法体外培养3T3-L1前脂肪细胞,在3T3-L1前脂肪细胞分化成熟过程中（0-10 d）,采用油红O染色,观察脂肪细胞分化及脂质积聚情况;采用Real-time PCR、逆转录PCR技术检测脂肪细胞分化标志基因（LEPTIN,ADIPONECTIN）和ANGPTL4 mRNA表达;采用Western ...
黄颖, 曹岩, 刘阳, 郑永晨
doaj  

[Reoxygenation improves reduced hypothalamic leptin responsiveness induced by intermittent hypoxia in obese rats]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Dong M, Zhu T, Ma J, DU X, Feng Y.
europepmc   +1 more source

[Exogenous leptin improves cerebral ischemia-reperfusion-induced glutamate excitotoxic injury in mice by up-regulating GLT-1 and GLAST expression in astrocytes]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Chen J, Liu C, Wang C, Li L, Tao W, Xun J, Tang H, Huang L.   +7 more
europepmc   +1 more source

[Association of leptin, adiponectin, and ghrelin in breast milk with the growth of infants with exclusive breastfeeding]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi, 2018
Huang LL, Yang F, Xiong F.
europepmc   +1 more source

[Construction of risk prediction models of hypothermia after transurethral holmium laser enucleation of the prostate based on three machine learning algorithms]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Jiang J, Feng S, Sun Y, An Y.
europepmc   +1 more source

[Effect of leptin on long-term spatial memory of rats with white matter damage in developing brain]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi, 2017
Feng EC, Jiang L.
europepmc   +1 more source

[Aerobic exercise regulates macrophage polarization and improves insulin resistance in mice: the mediating role of miR-221-3p]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Li N, Zhang L, Guo Q, Zhou Y, Liu C.
europepmc   +1 more source