Results 11 to 20 of about 1,673 (154)
Research Progress in the Regulation Mechanisms of White and Brown Adipose Tissue in the Body by Functionally Active Factors [PDF]
, 2023 Brown adipose tissue (BAT) improves the metabolic level of the body by promoting energy expenditure, which can contribute to the prevention and treatment of metabolic diseases such as obesity and diabetes, and BAT has become a new target for the ...
TAN Ting, LUO Yihao, SUN Wancheng
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Screening for pathogenic variants in obese cohort using whole-exome sequencing [PDF]
, 2023 Objective·To screen mutations of key genes in the leptin-melanocyte stimulating hormone (LEP-MSH) pathway by whole-exome sequencing (WES) in the obese cohort.Methods·A total of 119 obese patients aged 17－65 years old with body mass index (BMI)≥34 kg/m2 ...
CHEN Xianghui +8 more
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Research Progress on the Relationship between Osteoporosis and Cognitive Impairment [PDF]
, 2022 In recent years, studies have shown that among elderly comorbidities, the incidence of comorbidity between osteoporosis and cognitive impairment is increasing year by year, which is manifested as a high incidence of falls and an increased risk of ...
REN Yun, TAO Liyuan, FAN Dongwei
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Associations between urinary paraben levels and obesity of 10-year-old children [PDF]
, 2023 BackgroundParabens, a widely used class of preservatives, are suspected to be potential obesogens as emerging endocrine disrupting chemicals with reproductive and developmental toxicity.
Chunhua WU +10 more
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, 2018 目的通过测定妊娠期糖尿病患者血清中瘦素、可溶性瘦素受体（soulbe leptin receptor,sLR）、脂联素、抵抗素的含量,探讨脂肪细胞因子与妊娠期糖尿病发病的相关性,初步探索瘦素对胎儿发育的影响。方法选取2014年1-12月在厦门大学附属成功医院连续产检并分娩的673例孕妇为研究对象,跟踪随访至孕晚期。根据孕2428周糖耐量试验结果,采用随机抽样选取50例血糖控制良好的妊娠糖尿病患者纳入妊娠糖尿病组,根据一般资料进行匹配选取50例糖耐量试验结果阴性者纳入正常妊娠组 ...
兰天舒, 林戎, 沈忱, 黄昭穗
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补肾健脾方影响高脂肪饮食骨质疏松模型大鼠脂代谢及瘦素的变化 [PDF]
, 2018 背景:绝经也可导致体内瘦组织与脂肪成分的改变,现阶段发现骨质疏松在肥胖的老年人中的发生率要大于非肥胖者,由此推断瘦素可能是骨质疏松症发病机制中的一个重要调节因素。目的:探讨补肾健脾方对高脂肪饮食骨质疏松大鼠脂代谢及瘦素的影响。方法:将6月龄SPF级雌性SD大鼠220只随机分成模型组170只和假手术组50只。模型组行双侧卵巢结扎切除术,假手术组除未行卵巢结扎切除外,其余步骤同模型组。手术后12周,模型鉴定成功后,手术组随机分成正常饮食模型组、高脂饮食模型组、高脂饮食健骨颗粒组和高脂饮食辛伐他丁组各40只 ...
华鹏 +6 more
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Zhongguo shiyan zhenduanxue, 2009 目的探讨瘦素对闭经、不孕的影响,肥胖与血清瘦素水平的关系。方法通过放射免疫分析方法检测45例月经正常者和28例闭经患者及13例不孕患者中血清瘦素浓度,身体质量指数（BMI）与血清瘦素水平的关系。结果①闭经组及不孕组血清瘦素水平明显高于对照组,差异具有显著性 ...
张爱臣, 冷维春, 任丽华
doaj
, 2008 瘦素是一种由肥胖基因(Obgene)编码的分子量为16.7kDa的多肽类激素,具有降低食欲、增加能量消耗等重要生理作用。瘦素与肾脏的关系密切,肾脏是瘦素的主要清除器官,同时瘦素又可对肾脏功能产生直接作用,影响慢性肾功能衰竭患者的疾病进程。因此,研究者希望通过调节血清中瘦素水平 ...
付莉, 叶本兰
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老年男性高尿酸血症与血清脂联素、瘦素水平及其比值的相关性研究
Zhongguo shiyan zhenduanxue, 2008 目的研究老年男性血清脂联素、瘦素水平及其比值与血尿酸水平的相关性。方法选择122名年龄≥65岁的老年男性,以血清尿酸≥420μmol/l诊断为高尿酸血症,高尿酸组52人,尿酸正常组70人。采用放免法测定血清脂联素、瘦素水平,计算脂联素/瘦素比值（A/L）。结果老年男性高尿酸血症表现为高瘦素低脂联素,脂联素/瘦素比值下降;老年男性血尿酸水平与空腹血瘦素水平显著负相关,与空腹血脂联素水平及A/L比值显著负相关。结论血瘦素水平升高,脂联素水平下降是老年男性发生高尿酸血症的机制之一 ...
王熠华, 陶婷, 赵咏桔
doaj
Study on LEP genetic polymorphism, serum organochlorines pesticides (DDTs and HCHs) level and risk of cholesterol gallstone [PDF]
, 2017 研究背景 胆结石（Cholecystolithiasis）是世界范围的一种重要公共健康问题。近来年，随着人民生活水平的提高，饮食结构和行为生活方式的改变，我国人群的胆石症（尤其是胆囊胆固醇结石）发病率日趋增加。胆囊胆固醇结石的发生、发展与遗传、环境因素及体内激素（雌激素、瘦素等）水平等密切相关。环境中持久性有机污染物，如有机氯农药（Organicchlorinatedpesticides，OCPs）滴滴涕（dichlorodiphenyltrichloroethane，DDTs）和六六六 ...
陈静
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