Results 11 to 20 of about 6,894 (80)
Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023 Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang +6 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
Long‐term use of lokivetmab in dogs with atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 6, Page 683-693, December 2024.Background – Lokivetmab, a caninised monoclonal antibody against interleukin (IL)‐31, is an effective treatment for the pruritus associated with canine atopic dermatitis (cAD). Objectives – To investigate the efficacy and safety of lokivetmab during long‐term treatment defined as at least three consecutive lokivetmab injections in atopic dogs under ...
Bettina Kasper +2 more
wiley +1 more source
Maternal ethnicity and socioeconomic deprivation: influence on adverse pregnancy outcomes
Ultrasound in Obstetrics &Gynecology, Volume 64, Issue 2, Page 187-192, August 2024.ABSTRACT Objective To evaluate the relative importance of ethnicity and socioeconomic deprivation in determining the likelihood and prevalence of placentally derived composite of adverse pregnancy outcomes (CAPO) and composite of severe adverse pregnancy outcomes (CAPO‐S).
M. Minopoli +5 more
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Physiological Entomology, Volume 49, Issue 2, Page 67-90, June 2024.Olfactory receptor neurons (ORNs) in insect antennae project axons to glomeruli in the antennal lobe for odor processing by local interneurons. Uniglomerular projection neurons (PNs) relay processed odor information to the mushroom body and lateral horn.
Saleem Jaffar, Guy Smagghe, Yongyue Lu
wiley +1 more source
Integrative Conservation, Volume 3, Issue 1, Page 36-45, March 2024.Threatened and endangered species that occur in coastal areas are susceptible to the impacts of hurricanes that can destroy and reorganize their habitats. We used long‐term tracking of endangered beach mice to reveal they survive these impacts by using high elevation dune habitats to stay safe.
Michael V. Cove +5 more
wiley +1 more source
神经胶质细胞系衍生神经营养因子和雄激素受体在手术诱导隐睾小鼠睾丸管周细胞中的表达
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨神经胶质细胞系衍生神经营养因子（GDNF）和雄激素受体（AR）在隐睾症小鼠睾丸管周细胞中的表达水平及对隐睾症导致生精功能障碍的理论意义。方法30只5周龄雄性ICR小鼠采用随机数字表法随机分配至6组中，随机抽取3组15只小鼠进行手术诱导隐睾，其余3组为作为对照组进行假手术处理。分别于4 d、7 d、14 d后取各组睾丸组织，然后测量睾丸体积、观察睾丸组织病理，提取各组睾丸管周细胞后利用免疫荧光、Real-Time PCR和蛋白质印记法检测AR和GDNF的mRNA和蛋白的表达。结果对照组4 d、7 ...
吴飞 +4 more
doaj
CRP/ALB和sIL-2R水平与新生儿肺部感染病情程度及预后的相关性分析 附视频
Zhongguo shiyan zhenduanxue目的 分析C反应蛋白/白蛋白(CRP/ALB)和可溶性白细胞介素-2受体(sIL-2R)水平与新生儿肺部感染病情程度及预后的相关性。方法 选取2019年6月—2022年6月期间青岛市胶州中心医院收治的120例肺部感染的新生儿，所有患儿均进行CRP、ALB及sIL-2R水平检测，计算CRP/ALB。所有新生儿均取肺部分泌物进行病原菌培养，根据是否为细菌感染分为细菌感染组及非细菌感染组，根据病情严重程度分为轻度感染组和重度感染组，统计并比较细菌感染组及非细菌感染组、轻度感染组和重度感染组新生儿CRP ...
doaj +2 more sources