Results 31 to 40 of about 11,613 (155)
Veterinary Dermatology, Volume 37, Issue 1, Page 89-102, February 2026.ABSTRACT Background Recurrent otitis externa (OE) episodes commonly affect dogs with canine atopic dermatitis (cAD) despite ongoing cAD treatment. Objective To determine if a therapeutic diet with active ingredients targeting the skin barrier and allergy pathways reduces the incidence rate of OE.
Adrian Watson +5 more
wiley +1 more source
The Th cell subsets analysis of syphilis patients and mechanism of Treponema pallidum infection [PDF]
, 2016 梅毒是由梅毒螺旋体引起的性传播疾病。梅毒螺旋体可侵入人体各个组织器官，引起各种临床表现。目前机体对梅毒螺旋体的免疫机制尚不清楚。本课题分别从体内和体外实验分析梅毒螺旋体引起的初始Th细胞分化，初步探讨梅毒螺旋体细胞免疫机制。我们分析32例梅毒患者外周血辅助性T细胞（Th）亚群含量变化；通过兔皮内接种模型，分析梅毒螺旋体感染后局部炎症反应中IFN-γ和IL-4mRNA的表达随时间变化情况。体内研究发现梅毒螺旋体感染后细胞免疫应答在人外周血和兔皮损中IFN-γ含量明显升高，Th1型细胞增多 ...
张巧
core
Veterinary Dermatology, Volume 37, Issue 1, Page 140-147, February 2026.Background: Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and may be aggravated by topical antiseptics. Hypothesis and Objectives: To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs
Adamantia Pseftogka +3 more
wiley +1 more source
Wildlife Letters, Volume 3, Issue 4, Page 194-202, December 2025.This study establishes the optimal nonlethal laser deterrence range (210–260 W, 1s) for wild boars, preventing agricultural damage while ensuring animal safety. Results demonstrate that efficacy requires seasonal power adjustments (≤ 285 W in winter) and precise targeting control—enabling effective, injury‐free wildlife conflict mitigation.
Zhenyang Li +6 more
wiley +1 more source
The synthesis of triazole derivatives on mushroom tyrosinase and their mechanisms [PDF]
, 2016 酪氨酸酶广泛的存在于各生物体内，其产物多巴醌能与氨基酸或者蛋白质聚合黑色素，该酶是合成黑色素的关键酶。然而黑色素的过量合成会引起雀斑、黄褐斑、老年斑等色素沉积性皮肤病，此外研究表明，酪氨酸酶还与帕金森综合症、昆虫蜕皮、果蔬褐变有密切关系。因此，控制酪氨酸酶活性的研究在农业、制药业及化妆品行业有重要开发价值。 4-氨基-3-肼基-5-巯基-1，2，4-三唑（AHMT）为五元氮杂环，是酰胺键的电子等排物，也具有潜在的配位键，而苯甲醛类衍生物为酪氨酸酶底物的类似物，可以竞争性抑制酶失活性 ...
喻枫
core
Veterinary Dermatology, Volume 36, Issue 6, Page 814-824, December 2025.Background: Gabapentin reportedly decreases central sensitisation, a disorder associated with chronic pruritus in humans, although this is not well documented in cats. Its combined use with the standard antipruritic therapy for feline atopic skin syndrome (FASS) is not yet described.
Jeanne Morency +10 more
wiley +1 more source
Study on the inhibition to tyrosinase in Xinjiang plants [PDF]
, 2015 酪氨酸酶广泛存在于微生物，动植物及人体中，是一种多亚基的含铜的氧化还原酶。酪氨酸酶是合成黑色素的重要酶类，通过改变酪氨酸酶的活性可以控制黑色素生成量，从而对生物体内黑色素水平及相关代谢途径产生影响。 本文以新疆植物为研究对象，从新疆植物中提取了一批对蘑菇酪氨酸酶具有抑制作用的天然活性物质。多种植物都是首次研究，还没有文献报道。在理论上从酶学角度系统阐述了天然活性物质与蘑菇酪氨酸酶的作用机理及其生物活性。 本文经过粗提的植物，再经石油醚，乙酸乙酯，氯仿，正丁醇萃取，得到不同提取层的物质 ...
祁瑞
core
Hydrocortisone Aceponate for Chronic Otitis: Long‐Term Efficacy
Veterinary Dermatology, Volume 36, Issue 6, Page 870-878, December 2025.Effective management of otitis externa (OE) requires addressing all contributing factors to prevent chronicity and recurrence. Evidence on the long‐term efficacy of topical corticosteroids in preventing recurrence and secondary infections remains limited. This retrospective noncontrolled study evaluated the efficacy of hydrocortisone aceponate (HCA) in
C. Lorente‐Méndez, D. Alonso‐Miguel
wiley +1 more source
The role of jumping translocation breakpoint gene promoting instability of genome and the biological function of its protein and potential clinical value [PDF]
, 2014 染色体不稳定性是大多数肿瘤细胞特别是实体瘤细胞和体外转化细胞的基本特征。其表现形式包括整条染色体的获得或缺失，杂合缺失，染色体易位重排，基因扩增等。目前认为染色体不稳定是肿瘤形成的始发因素，出现在肿瘤进展的早期阶段。体内外各种损伤刺激导致的基因组DNA链的断裂是染色体不稳定的根本原因。我们的研究发现，跳跃易位断裂点基因（JTB）在胃癌、肝癌中存在广泛的基因扩增和基因易位行为，而基因的扩增和易位是DNA双链断裂后异常修复的最终结果。JTB基因的断裂易位将导致其编码跨膜结构域的基因序列丢失 ...
刘贇鹏
core
Veterinary Dermatology, Volume 36, Issue 5, Page 647-659, October 2025.Background – Inhibition of the Janus kinase (JAK) pathway is a well‐established option for canine atopic dermatitis (cAD). Objective – To evaluate the efficacy and safety of ilunocitinib, a novel JAK inhibitor for the control of pruritus and skin lesions in client‐owned dogs with cAD.
Sophie Forster +5 more
wiley +1 more source