麻醉药布比卡因对卵巢癌干细胞样细胞中Wnt/β-catenin信号通路关键分子的影响
目的观察麻醉药布比卡因对卵巢癌干细胞样细胞(Ovarian cancer stem-like cells,OCSLCs)中Wnt/β-连环蛋白(β-catenin)信号通路关键分子的影响。方法取SKOV3细胞系细胞进行体外培养,通过悬浮培养法获得OCSLCs,采用不同浓度(1 μM、10 μM、100 μM、1 mM)布比卡因处理OCSLCs,分为1 μM组、10 μM组、100 μM组及1 mM组,并设置空白对照组与安慰剂对照组(同等剂量浓度0.9%生理盐水处理),采用免疫组化法检测各组Wnt3a、β-
李梅, 赵建华, 赵石磊
doaj
[High expression of MPP6 predicts poor patient prognosis and promotes malignant biological behaviors of hepatocellular carcinoma cells]. [PDF]
Yu H +5 more
europepmc +1 more source
[<i>Yiqi Jiedu</i> Formula inhibits proliferation, invasion and migration of nasopharyngeal carcinoma cells by inhibiting the AKT1/GLUT1 signaling pathway]. [PDF]
Xu H +8 more
europepmc +1 more source
[Polyphyllin VII inhibits osteosarcoma xenograft growth in mice by inducing ferroptosis via upregulating SOHLH1]. [PDF]
Xiao D +10 more
europepmc +1 more source
[The role and mechanisms of N,N-dimethylglycine sodium in promoting wound healing in mice]. [PDF]
Guo S +8 more
europepmc +1 more source
NAD+激活SIRT3/IDH2信号通路改善高血压血管内皮功能障碍
目的探讨烟酰胺腺嘌呤二核苷酸在改善高血压血管内皮损伤中的作用及其分子机制。方法利用渗透泵构建高血压小鼠模型,将C57BL/6J小鼠随机分为生理盐水组(Saline)和高血压组(Ang Ⅱ),每天补充NAD+前体——烟酰胺单核苷酸(300 mg/kg),4周后检测小鼠血压、内皮舒张功能、脉搏波传导速度。采用迁移实验和划痕实验评估体外内皮细胞功能;采用免疫荧光染色法检测mtROS水平;采用RT-PCR检测mtDNA、SIRT3、异柠檬酸脱氢酶2(IDH2)的mRNA表达;采用酶联免疫吸附法检测8-羟基-2'-
丘雨旻 +7 more
doaj
[Silencing DDX17 inhibits proliferation and migration of pulmonary arterial smooth muscle cells <i>in vitro</i> by decreasing mTORC1 activity]. [PDF]
Deng X +6 more
europepmc +1 more source
[Advances in Lactate Metabolic Reprogramming in Non-small Cell Lung Cancer]. [PDF]
Zhou J, Ge L, Jiang J.
europepmc +1 more source
[<i>Huangqin Qingre Chubi</i> Capsule inhibits JAK/STAT-driven synovial angiogenesis in rheumatoid arthritis by suppressing the LncRNA EBLN3P/miR-369-3p/NFIX axis]. [PDF]
Sun M, Wang Y, Liu F.
europepmc +1 more source
[Extracellular matrix materials and tissue regeneration and repair]. [PDF]
Zhao L, Xie H.
europepmc +1 more source

