, 2006 采用可生物降解高分子材料作为膜材，制备包埋蛋白质和多肽类药物的缓控释纳米微囊，以达到增强药物的靶向性、缓释性、可控性、低毒性以及智能性的目的，已成为目前各国学者研究的前沿热点。针对传统纳米微囊制备方法普遍存在的制备过程重复性差、粒径均一性差、包埋率低以及所包埋药物易失活等缺点，本文发展了以快速膜乳化技术与复乳法-分步固化法相结合的工艺，旨在制备粒径均一、包埋率较高、药物活性保持好的纳米载药微囊，并对快速膜乳化工艺参数以及该工艺内在规律进行研究。 快速膜乳化工艺制备纳米载药微囊主要分三步 ...
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