Zhongguo youzhi, 2023 为研发具有预防酒精性脑损伤功效的天然活性肽类产品，将SD大鼠随机分为7组，分别为对照组、模型组、玉米肽实验组(剂量分别为125、250、500、1 000、2 000 mg/kg)，采用50度北大仓部优白酒灌胃建立大鼠慢性酒精中毒脑损伤模型，造模结束后取脑组织进行病理组织学观察，同时采用酶联免疫试剂盒检测各组大鼠脑组织中氧化应激、炎性因子、部分神经递质及其他相关指标。结果表明：酒精可使脑组织神经细胞发生病理性改变，玉米肽干预可有效缓解酒精对脑组织的损伤作用；玉米肽能够减少酒后大鼠脑组织中ROS含量 ...
林巍，毛梦雨，刘晓兰，任健 LIN Wei，MAO Mengyu，LIU Xiaolan，REN Jian
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rLent/NT4-NAP对老年性痴呆大鼠海马神经元保护作用的研究
Zhongguo shiyan zhenduanxue, 2008 目的探讨神经保护肽慢病毒（rLent/NT4-NAP）对老年性痴呆（AD）大鼠海马神经元的保护作用。方法选择无菌级雄性Wister大鼠40只,随机分为对照组,假手术组,AD组,rLent/NT4-NAP组,每组10只。建立β-淀粉样蛋白（Aβ）大鼠海马注射的实验性AD大鼠动物模型[2],利用水迷宫试验检测大鼠记忆能力,组织切片HE染色观察大鼠海马神经元变化,免疫组织化学染色观察caspase-3的表达。结果与AD组相比,rLent/NT4-NAP组水迷宫试验逃避潜伏期明显缩短,错误次数显著降低 ...
白晶, 杨弋, 杨薇, 吴江
doaj
实验性阿尔茨海默模型大鼠海马内病理和PCNAmRNA表达的变化及rLent/NT4-NAP对其的影响
Zhongguo shiyan zhenduanxue, 2011 目的探讨实验性阿尔茨海默病模型大鼠脑内海马光镜下的变化和DNA修复蛋白PCNAmRNA表达的变化,进一步探讨神经保护肽慢病毒rLent/NT4-NAP（NAP）对其具有神经保护作用机制。方法选择无菌级雄性大鼠Wister大鼠40只,随机分为对照组,假手术组,阿尔茨海默（AD）模型大鼠组,rLent/NT4-NAP（NAP）组,每组10只。建立Aβ1-40联合应用转移生长因子β1（TGFβ1）注入实验大鼠左侧海马区制备阿尔茨海默动物模型,通过HE染色观察各组大鼠海马区的形态学改变 ...
白晶, 房绍宽, 张影, 周春奎
doaj
神经保护肽重组慢病毒对老年痴呆大鼠行为学及海马结构内NF-kBmRNA表达的影响
Zhongguo shiyan zhenduanxue, 2008 目的探讨神经保护肽慢病毒（rLent/NT4-NAP）感染老年痴呆大鼠鼻粘膜后分泌的NAP对老年性痴呆（AD）大鼠行为学及海马内NF-kBmRNA表达的影响。方法选择无菌级雄性Wister大鼠40只,随机分为对照组,假手术组,AD组,rLent/NT4-NAP组,每组10只。建立β-淀粉样蛋白（Aβ）大鼠海马注射的实验性AD大鼠动物模型[2],利用水迷宫试验检测大鼠记忆能力,利用原位杂交的方法观察大鼠海马内NF-kBmRNA的表达。结果与AD组相比,rLent/NT4 ...
白晶, 杨弋, 杨薇, 吴江
doaj
[Therapeutic potential of extracellular vesicles in neurological diseases]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoDU Q, Yang C, Xia X, Wang T.
europepmc +1 more source
[Research on the pathogenesis and treatment of diabetic foot ulcer wounds]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiWang X, Wang YY, Qi JW.
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[Sulforaphane reduces reactive astrocyte-mediated neuron apoptosis <i>in vitro</i> by inhibiting the MAPK/NF-κB signaling pathway in Aβ42 oligomer-activated astrocytes]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang S +5 more
europepmc +1 more source
[Molecular imprinting strategies and advances targeting biomembranes]. [PDF]
Se PuYuan XT, Wang L, Chen LX, Hu LH.
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[Shihu Mixture alleviates diabetic cardiomyopathy in rats by Sirt3-mediated upregulation of myocardial mitochondrial mitophagy pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLin X, He Y, Shi H, Liu J, Hu H.
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[<i>Sangma Zhike</i> Formula alleviates airway inflammation and hyperresponsiveness in rats with postinfectious cough by inhibiting the TRPV1-SP/CGRP and pyroptosis pathways]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoYang Q +7 more
europepmc +1 more source