Results 21 to 30 of about 7,441 (160)
A systematic review exploring palliative care for families who are forced migrants 对被迫移民家庭姑息治疗的系统回顾
Journal of Advanced Nursing, Volume 76, Issue 11, Page 2872-2884, November 2020., 2020 Abstract Aims To explore the palliative care experiences of forced migrant children, families, and healthcare professionals (HCPs) highlighting successes, challenges, and associated practice implications. Design Systematic literature review. Data Sources The following search engines were searched from 2008 ‐ 2018: Allied and Complementary Medicine ...
Marie Clancy +3 more
wiley +1 more source
The neuronal cell cycle regulation mechanism and related animal model in Alzheimer’s disease [PDF]
, 2015 阿尔茨海默病（Alzheimer’sDisease，AD）是一种与年龄相关的神经退行性疾病，它的主要临床表现是记忆和认知功能的逐渐衰退。AD是一种严重影响人类健康的神经退行性疾病，至今仍未找到有效的治疗方法。因此从预防和早期治疗角度考虑，对于AD早期病理变化的研究就十分重要。成熟神经元处于细胞周期静止期，而在AD中，大量神经元的细胞周期被重新激活，但这些神经元不会再分裂而是最终走向了凋亡，这是目前在AD小鼠模型中已知最早的细胞功能紊乱。但对细胞周期重新激活导致神经元凋亡的机制目前还不清楚 ...
李小萍
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Deep quantile regression for growth and maturation reaction norms
Methods in Ecology and Evolution, Volume 17, Issue 1, Page 111-124, January 2026.Abstract Understanding species' growth and maturation responses to anthropogenic and environmental pressures is crucial for tracking demographic shifts, phenotypic change and ensuring population sustainability. Traditional regression methods often focus on modelling the conditional mean of life‐history traits, potentially overlooking heterogeneity in ...
Guankui Liu +4 more
wiley +1 more source
the mechanism investigation of neuronal specific protein CEND1on cell proliferation [PDF]
, 2015 阿尔茨海默病(Alzheimer’sdisease,AD)是一种神经退行性疾病，临床表现 为渐进性的记忆力丧失以及认知障碍。大量研究阐述了AD的病理特征和微观机 制，但目前为止尚未找到有效的治疗途径，因此继续深入研究AD致病过程，对 于疾病的预防和治疗具有重要意义。研究证实，区别于正常神经元终末分化和停 止分裂的生理状态，AD病人大脑中的神经元细胞周期会发生紊乱，部分神经元 能够重新进入细胞周期。这些神经元的细胞周期被重新激活后，进入细胞凋亡途 径CRND ...
牛雅琼
core
Journal of Analytical Psychology, Volume 70, Issue 4, Page 616-639, September 2025.Abstract Patricia Berry’s interpretation of the Demeter/Persephone myth, and her concept of rape into consciousness, illuminate intrapsychic dynamics. However, this symbolic lens may inadvertently distance us from the devastating nature of literal rape—a reality the Homeric Hymn encapsulates.
Barbara Cerminara
wiley +1 more source
The Role of Cdk5 in neuronal death and synaptic dysfunctions through phosphorylating FOXO1 and BAG3 [PDF]
, 2016 细胞周期蛋白依赖性激酶5（Cyclin-dependentkinase5，Cdk5）是由脯氨酸介导的丝氨酸/苏氨酸蛋白激酶，其在神经系统中发挥着重要的作用。Cdk5的活化主要靠神经系统中广泛表达的两个激活因子p35和p39。Cdk5对神经系统的正常生理功能具有重要作用去，其可通过磷酸化众多底物的丝氨酸/苏氨酸位点，在神经元的迁移分化，突触传递，轴突树突的发育过程以及神经元的存活中都发挥着重要的作用。此外，在某些病理条件下，Calpain所介导的p35切割形成p25，可以过度激活Cdk5 ...
周杰超
core
Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1387-1399, August 2025.Post‐stroke depression (PSD) animal model of traditional Chinese medicine (TCM) combined with disease and syndrome often uses western medicine surgery (including: middle cerebral artery embolization to construct cerebral ischemia, or brain injection of collagenase to construct cerebral hemorrhage) combined with other methods (including: isolation ...
Jielin Wang +4 more
wiley +1 more source
Improving reporting of meta‐ethnography: The eMERGe reporting guidance 改进元人种志的报告:新兴报告指南
Journal of Advanced Nursing, Volume 75, Issue 5, Page 1126-1139, May 2019., 2019 Abstract Aims The aim of this study was to provide guidance to improve the completeness and clarity of meta‐ethnography reporting. Background Evidence‐based policy and practice require robust evidence syntheses which can further understanding of people's experiences and associated social processes. Meta‐ethnography is a rigorous seven‐phase qualitative
Emma F. France +21 more
wiley +1 more source
The study on protein level, lipidation state and protein stability of apolipoprotein E [PDF]
, 2015 阿尔兹海默症（Alzheimer’sdisease，AD）是老年人群中最常见的痴呆类型。按AD的发病年龄可以将AD划分为早发型AD和晚发型AD，绝大多数的AD病人属于晚发型AD。载脂蛋白E（apoE）存在ε2、ε3、ε4三种常见的等位基因，其中的ε4等位基因是晚发型AD最重要的危险因素，而ε2等位基因可以降低人类罹患阿尔兹海默症的风险。ApoE是脑中主要的载脂蛋白，在脑中胆固醇及其它脂质的运输过程中发挥重要作用。ApoE通过调节Aβ的清除及脂质转运等机制在AD的病理学过程中发挥重要作用 ...
史新震
core
Veterinary Dermatology, Volume 36, Issue 4, Page 401-411, August 2025.Background – Itch is a common symptom in skin disorders. While the neural pathways of itch transmission from the skin to the brain are well‐understood in rodents, the same pathways in dogs remain unclear. The knowledge gap hinders the development of effective treatments for canine itch‐related disorders.
Chie Tamamoto‐Mochizuki +1 more
wiley +1 more source