Results 61 to 70 of about 5,845 (120)

Nrf2通过上调自噬促进C17.2神经干细胞的增殖

Zhongshan Daxue xuebao. Yixue kexue ban, 2016
摘 要: 【目的】 通过使用化合物调控细胞内信号通路,最终引起脑内神经干细胞的增殖和分化?这被为认为是一种崭新的修复受损大脑功能的治疗策略?我们发现Nrf2能够调控C17.2神经干细胞的增殖,并试图阐明其可能的作用机制?【方法】 采用MTT法检测细胞活力,BrdU掺入法检测细胞增殖,western blot法检测细胞内蛋白水平的变化,流式细胞术检测细胞内ROS水平的变化?【结果】 Nrf2的激动剂t-BHQ和SFN可以促进C17.2神经干细胞的增殖,而使用Nrf2的抑制剂brusatol则抑制其增殖 ...
doaj  

[Autologous hematopoietic stem cell transplantation with TBE conditioning in patients with primary central nervous system lymphoma]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Chen JL, Ma Y, Zhao RQ, Xiao XB, Chen XL, Yuan SZ, Zhao SH, Lu Y, Gao HH, Wang YQ, Yin H, Cheng NN, Feng P, Bai XR, Huang WR.   +14 more
europepmc   +1 more source

成人骨髓间质干细胞分化为神经元样细胞及与凋亡的关系

Zhongshan Daxue xuebao. Yixue kexue ban, 2004
【目的】探讨体外诱导成人骨髓间质干细胞(humanmesenchymalstemcells,hMSC)向神经元样细胞分化过程中分化与凋亡的关系,为进一步研究延长神经元样细胞的存活时间提供基础。【方法】从成人骨髓分离MSC,培养扩增。以β-巯基乙醇和参芪液诱导分化,于诱导后1、3、5h分别进行免疫组化鉴定神经元烯醇化酶(NSE)、神经丝蛋白(NF)、胶质纤维酸性蛋白(GFAP)的表达,计数神经元样细胞,计算分化率。采用TUNEL方法分别检测诱导后1、3、5h的细胞凋亡率,并分析两者是否相关。【结果 ...
doaj  

[Gastrodin inhibits ferroptosis to alleviate hypoxic-ischemic brain damage in neonatal mice by activating GPX4/SLC7A11/FTH1 signaling]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Guo T, Chen B, Shi J, Kuang X, Yu T, Wei S, Liu X, Xiao R, Li J.   +8 more
europepmc   +1 more source

[Analysis of induction therapy response in children with high-risk neuroblastoma]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Wang Y, Zhang T, Huang C, Liao XL, Yang JW, Jiang SY, Shao JB.   +6 more
europepmc   +1 more source

[Human umbilical cord mesenchymal stem cells protect against neonatal white matter injury by activating the Nrf2/Keap1/HO-1 signaling pathway]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Wang C, Wang MX, Zhu YP.
europepmc   +1 more source

[Stem cell therapy for premature ovarian insufficiency: a review of clinical evidence and therapeutic strategies]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Cheng Z, Lai D.
europepmc   +1 more source

[The microbiota-gut-brain axis in childhood attention-deficit/hyperactivity disorder: mechanisms and therapeutic advances]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Yuan YL, Lan YM, Guo LM.
europepmc   +1 more source

[Establishment and application of key technologies for periodontal tissue regeneration based on microenvironment and stem cell regulation]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Ma B, Li J, Sang Y, Yu Y, Qiu J, Shao J, Li K, Liu S, DU M, Shang L, Ge S.   +10 more
europepmc   +1 more source

[Systemic lupus erythematosus complicated by autoimmune nodopathy: A case report]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Wei C, Yang Y, Zhao X, Liu X, Jia Y.
europepmc   +1 more source