Results 11 to 20 of about 2,842 (179)
A型肉毒毒素调控钠离子通道Nav1.8缓解神经病理性疼痛的作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2014 摘 要: 【目的】 研究A 型肉毒毒素(BoNT/A)对腰5脊神经前根切断(L5 VRT)介导的神经病理性疼痛的影响,并进一步探讨其可能的内在作用机制?【方法】 利用行为学测试方法观察BoNT/A足底注射后对L5 VRT大鼠机械刺激撤足阈值的影响,采用Western blot方法分析BoNT/A对L5 VRT术后背根神经节(DRG)神经元中钠离子通道(Nav1.8)蛋白表达的影响,并进一步应用全细胞膜片钳技术观察BoNT/A对DRG神经元中功能性Nav1.8电流密度的影响?【结果】 一侧足底注射7?15
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Translocator protein activates autophagy in diabetic neuropathic pain rats via regulation of the Keap1/Nrf2/HO-1 signaling [PDF]
, 2023 Objective·To study the effects of translocator protein (TSPO) agonist Ro5-4864 on autophagy and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid-derived-2-like 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling in diabetic neuropathic pain ...
GAO Nan +5 more
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Research progress on the neural circuit of pain emotion mediated by amygdala [PDF]
, 2023 The occurrence of pain emotion is closely related to the functional and structural changes of specific central nervous circuit. When pain is accompanied by depression, anxiety, pain aversion memory and other emotional states, it activates or inhibits ...
MA CUI, YAN Xingke, YE Yujuan
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中西医结合护理, 2023 To summerize the effect of moxibustion therapy and nursing interventions on the peripheral neuropathic pain of lower limbs caused by oxaliplatin. A comprehensive pain assessment was conducted for the establishment of following nursing plan.
ZHANG Yue (张悦) +1 more
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Journal of Traumatic Stress, Volume 33, Issue 6, Page 1060-1070, December 2020., 2020 Abstract Survivors of traumatic events commonly suffer from long‐term pain and related somatic symptomatology. To test the predominant hypothesis that survivors’ pain comprises sequela of persistent posttraumatic stress symptoms (PTSS), we assessed the sequential order of symptom development among young survivors of a terrorist attack.
Synne Øien Stensland +4 more
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New concept of de-escalation management strategy in breast cancer patients with 1-2 positive sentinel lymph nodes [PDF]
, 2023 In the era of sentinel lymph node biopsy (SLNB), the axillary management concept that 1-2 positive sentinel lymph node (SLN) could safely omit axillary lymph node dissection (ALND) are gradually being accepted by more and more patients.
BI Zhao, WANG Yongsheng
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小鼠岛叶皮质5型代谢型谷氨酸受体对神经病理性疼痛的调控作用 [PDF]
, 2018 目的:通过保留性神经损伤(SNI)模型,探索神经病理性疼痛发生后,岛叶皮质(IC)中FOS蛋白和5型代谢型谷氨酸受体(m Glu R5)及其下游分子的表达变化,并观察对岛叶皮质局部应用m Glu R5激动剂DHPG和拮抗剂MPEP对动物疼痛行为的影响。方法:将健康成年的雄性C57BL/6小鼠随机分为SNI组和假手术组(Sham组),SNI组采用SNI模型制造神经病理性疼痛模型。造模后通过机械痛行为学检测造模是否成功,通过免疫荧光染色检测岛叶皮质FOS蛋白的表达变化,通过Western ...
侯立朝 +4 more
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电针对SNI诱导疼痛抑郁模型大鼠海马AcH3/BDNF的影响 [PDF]
, 2023 目的观察电针对疼痛抑郁模型大鼠海马脑源性神经营养因子（BDNF）、乙酰化蛋白（AcH3）表达的影响，探讨电针镇痛抗抑郁的作用机制。方法雄性SD大鼠随机分为假手术组、模型组、电针组、药物组，每组6只。采用坐骨神经选择损伤术（SNI）建立疼痛抑郁模型。SNI术后1周进行相关干预直至术后6 周，电针组于隔日电针百会、印堂2 Hz 30 min治疗；药物组给予每日10 mg/kg丙咪嗪腹腔注射；假手术组、模型组给予相同的抓取。术前及术后1、2、3、4、5、6 周进行机械缩足反射阈值（PWT）测试 ...
刘健华 +6 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2011 评估联合应用异烟肼(INH)治疗在难治性神经病理性疼痛(NP)治疗中的价值【方法】 采用前瞻性联合用药的自身对照研究,36例患有难治性NP的病人入组,这些病人对卡马西平和加巴喷丁联合治疗无效,给以异烟肼8 mg/kg联合治疗,观察期8周,检测其疗效和副作用治疗前后采用采用视觉模拟量表(VAS)睡眠干扰评分和病人总体印象改变表(PGIC)进行疗效评定【结果】 经过8周治疗后,VAS评分较加用异烟肼前有明显下降(配对t 检验P < 0.01),VAS评分由治疗前的61.76下降至32.94,下降幅度达46 ...
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, 2021 意识障碍严重影响患者的生命状态和生活质量。随着国内外医学技术的进步，意识障碍患者康复促醒技术也不断发展，包括药物治疗、针刺、高压氧治疗、神经调控治疗等，但疗效不一。本文综述了各种中枢及外周神经调控技术在昏迷促醒中的临床应用及其治疗机制 ...
马超
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