Results 1 to 10 of about 2,163 (140)
Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】 加强对类风湿关节炎(RA)合并干眼症的认识，重视继发干燥综合征的早期诊断。【方法】 总结52例RA患者合并有眼干症状的临床特点，进行干眼三项试验；分析关节、血液沉降率(ESR)、抗核抗体谱、类风湿因子(RF)及免疫相关检查等。【结果】 52例中有干眼自觉症状者12例占23.1%，Schirmer试验阳性者39例(占75.0%)，BUT阳性者48例(占92.3%)，FL阳性者26例(占50.0%)，其中二项以上检查阳性者22例占(42.3%)；IgA、IgM&、IgG、IgE、C3 ...
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Bullous pemphigoid complicated with macroamylasemia: a case report [PDF]
, 2022 High amylase level is a typical sign of acute pancreatitis. However， it can also be found in other diseases. In the article， a case of persistent elevation of amylase level for over 1 year was reported.
Zhang Feiya, Mu Manna, Lin Ying, Yang Yi, Zhu Donglin, Jiang Baiquan, Zhang Guochao, Mu Panwei
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Clinical research on progress of antinuclear antibody in rheumatoid arthritis [PDF]
, 2023 Rheumatoid arthritis (RA) is a common chronic, systemic autoimmune disease characterized by erosive arthritis, with a global prevalence of 0.25% to 1.00%, which may ultimately lead to joint deformity and loss of function.
LI Yuan, ZHANG Le, YIN Hanlin, ZHENG Bing, LÜ Liangjing
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Primary biliary cholangitis complicated with eosinophilic granulomatous with polyangiitis: a case report [PDF]
, 2023 The etiology of primary biliary cholangitis （PBC） is unclear， which may be associated with genetic， hereditary and environmental factors， etc. Ursodeoxycholic acid （UDCA） is the first-line drug for the treatment of PBC.
Xiao Qiao, Xiao Hua, Wang Rong, Zhao Chuan
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Clinical Featuresof IgG4-related Disease [PDF]
, 2022 BackgroundIgG4-related disease (IgG4-RD) is a rare fibro-inflammatory disease, which is prone to missed diagnosis or misdiagnosis due to nonspecific clinical manifestations.ObjectiveTo analyze the clinical characteristics of IgG4-related disease (IgG4-RD)
DING Hang, LIU Yuan, ZHANG Lianfeng, ZHOU Lin
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The role of histone acetylation in Rheumatoid arthritis peripheral blood mononuclear cells [PDF]
, 2016 研究背景类风湿关节炎（rheumatoidarthritis，RA）是一种常见的全身性自身免疫疾病，以慢性、进行性、侵袭性关节炎为主要临床表现。该病发病机制尚不明确，研究其发病机制对临床指导治疗具有极其深远的意义。组蛋白乙酰化在RA的发病机制中具有重要作用。组蛋白乙酰化是一种可逆的动态过程，主要由组蛋白乙酰转移酶(histoneacetylase，HATs)和组蛋白去乙酰化酶(histonedeacetylases，HDACs）协调修饰。既往研究中，Huber，L.C.等人的研究显示 ...
宋丽娜
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TIPE2 promote synovial fibroblasts cell apoptosis of adjuvant arthritis rats by up-regulating caspase while down-regulating NF-κB [PDF]
, 2015 目的：TIPE2能够抑制炎症以及肿瘤的发生发展，并且TIPE2过表达能够促进细胞的凋亡。类风湿关节炎是一种免疫多态性慢性疾病，我们应用类风湿关节炎模型大鼠佐剂型关节炎滑膜成纤维样细胞(fibroblast-likesynoviocytesofratadjuvantarthritis，AA-FLS)，通过体外实验分析TIPE2对死亡受体5诱导细胞凋亡的作用探讨TIPE2对佐剂型关节炎发病的影响。 方法：通过RT-PCR、荧光实时定量PCR和Western ...
石春燕
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Treatment of refractory severe dry eye with 0.1% tacrolimus eyedrops [PDF]
, 2016 目的：评估0.1%他克莫司滴眼液治疗难治性重度干眼疗效。 方法：本研究招募已使用人工泪液合并激素治疗半年或半年以上，但干眼症状及体征未见明显缓解的重度干眼患者26名。所有给予0.1%他克莫司滴眼液合并人工泪液治疗，并于治疗前、治疗后1月、2月及3月观察干眼相关临床指标，包括：干眼症状评分(OcularSurfaceDiseaseIndex，OSDI)、泪膜破裂时间(Tearbreakuptime，TBUT)、泪液分泌试验(SchirmerI)、角膜荧光素钠染色评分 ...
杨舒
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Zhongguo shiyan zhenduanxue, 2011 目的调查抗环瓜氨酸肽（CCP）抗体和类风湿因子在类风湿关节炎实验诊断中的敏感性、特异性和结果相关性。方法对健康体检者102例、类风湿关节炎患者128例和非类风湿关节炎患者151例的抗CCP抗体和类风湿因子检测结果进行统计分析。抗CCP抗体采用ELISA法检测,类风湿因子采用免疫比浊法检测。结果抗CCP抗体和类风湿因子对于类风湿关节炎的敏感性分别为76.6%、86.7%（P0.05）。结论抗CCP抗体对类风湿关节炎的特异性明显优于类风湿因子,而敏感性略低;抗CCP抗体与类风湿因子定量检测结果间无显著相关性。
邵耀明, 倪芳颖, 陈国千
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