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细胞角蛋白19片段抗原21-1含量化学发光微粒子定量免疫检测方法的建立 [PDF]
, 2018 目的建立细胞角蛋白19片段抗原21-1(cytokeratin 19 fragment 21-1,CYFRA21-1,简称CY21-1)含量的化学发光微粒子免疫检测方法(chemiluminescent microparticle immunoassay,CMIA)。方法原核表达制备重组CY21-1(r CY21-1),用其免疫BALB/c小鼠后,收集小鼠脾脏细胞,常规杂交瘤技术与Sp2/0进行融合,制备CY21-1单抗。间接ELISA法筛选可稳定分泌CY21-1抗体的杂交瘤细胞,分别标记微性磁珠 ...
刘江武 +5 more
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Test and Significance of CEA, NSE, CA125, CYFRA21-1 in Lung Cancer [PDF]
, 2017 目的 探讨CEA、NSE、CA125、CYFRA21-1在肺癌中的检测及意义.方法 回顾性分析2015年10月—2016年12月医院收治的肺部疾病患者166例,其中89例肺癌患者设为肺癌组,其余77例肺部良性病变患者设为肺部良性病变组.另选择35名健康志愿者作为健康对照组,电化学发光法检测3组血清中CEA、NSE、CA125、CYFRA21-1含量,分析单项及联合检测对肺癌的诊断价值.结果 肺癌组患者血清CEA、NSE、CA125、CYFRA21-1分别为（4.32±0.83）ng/mL、（11.54 ...
何佳瑜, 何正, 罗世翊, 魏玲
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, 2021 膀胱癌是泌尿系统最常见的肿瘤之一，当前膀胱镜检查加病理活检是确诊和随访观察治疗后肿瘤复发进展的金标准，但该检查技术有创且存在有时因尿道狭窄、肿瘤出血致视野不清、取材不充分而影响判断等缺点。因此开发能媲美于膀胱镜检查的无创诊断方法一直是研究者们关注的热点。本文通过文献检索分析归纳总结近10年关于膀胱癌尿液无创诊断研究现状 ...
陈炜
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Zhongguo shiyan zhenduanxue, 2022 肺癌是我国死亡率最高的恶性肿瘤[1]。非小细胞肺癌（NSCLC）作为常见的诊断类型，约占肺癌的85%，其发病隐匿，受目前检测方法限制，约75%NSCLC患者诊断时已为晚期，5年生存率不足20%[2]。目前，临床常用的肺癌血清肿瘤标志物有癌胚抗原（CEA）、糖类抗原125(CA125)、细胞角蛋白片段19(CYFRA21-1)、神经元特异性烯醇化酶（NSE）等，但它们的敏感度均较低，尚难满足肺癌的临床诊断需求，特别是对于早期肺癌的识别[3]。因此，探寻高敏感度、高特异度的新型肿瘤标志物 ...
张浩, 张逊, 孙大强
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Zhongguo shiyan zhenduanxue, 2020 食管癌为常见的恶性肿瘤之一,临床早期不易被发现,具有较高的发病率和死亡率。研究表明当人体消化系统出现病变时,机体内相关血清指标会随之而改变[1-3]。本文通过监测食管癌患者手术前后血清中鳞状细胞癌抗原(SCC)、癌胚抗原(CEA)、糖类抗原199(CA199)、细胞角蛋白19片段(CYFRA21-1)四种肿瘤标志物水平的变化,探讨以上肿瘤标志物对食管癌诊断以及预后判断的评估价值。
李春霖 +9 more
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Establishment of discriminative models for predicting the infiltration degree of patients with lung adenocarcinoma based on clinical laboratory indicators [PDF]
Objective·To establish a multifactorial discriminative model for predicting the degree of infiltration in patients with non-small cell lung adenocarcinoma based on clinically accessible laboratory indicators, such as tumor markers, coagulation function ...
HUANG Lin +3 more
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Analysis of risk factors related to thyroid function abnormality caused by programmed death-1 inhibitors [PDF]
ObjectiveTo investigate the clinical characteristics and influencing factors of thyroid function abnormality (TFA) in patients with malignant tumors receiving programmed death-1 (PD-1) inhibitor therapy, and its correlation with PD-1 inhibitors. MethodsA
Huiyang SONG +4 more
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Research advances in the association of epithelial cell adhesion molecule with lung cancer, breast cancer, and some digestive system tumors [PDF]
Epithelial cell adhesion molecule (EpCAM) was first identified in colon cancer cells and is involved in the regulation of cell adhesion, proliferation, differentiation, migration, and signal transduction.
CUI Jiali, WANG Qing
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尿细胞角蛋白19在膀胱移行细胞癌术后监测中的应用 [PDF]
, 2005 目的 评价尿细胞角蛋白19片段(CK19,又称CYFRA2 1 1)在膀胱移行细胞癌(BTCC)术后监测中的作用。方法 对67例保留膀胱的BTCC术后患者定期行膀胱镜检查发现2 1例复发,采用电化学发光免疫分析(ECLIA)技术测定复发组(2 1例)、未复发组(4 6例)和正常对照组(2 4例)的尿CKl9含量。结果 复发组尿CKl9的平均值为(19.60±18.5 7) μg/L ,明显高于未复发组(2 .3 3±1.64 ) μg/L和正常对照组(1.82±0 .83 ) μg/L ...
张忠英 +4 more
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Progress of Research on Diganosis and Treatment of Malignant Pleural Effusion [PDF]
Malignant pleural effusion (MPE) is one of the most common complications of advanced malignant diseases. The patients with MPE have a short survival time and poor prognosis.
Lifeng WANG, Ye LIU
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