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TK-1 和 TIMP-1 过表达对大鼠心肌梗死后心室重塑的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 【目的】探讨重组腺病毒介导的人TK-1和TIMP-1基因过表达对大鼠心肌梗死后的左室（LV）功能、炎症因子表达的影响及其机制。【方法】通过结扎Sprague-Dawley雄性大鼠冠脉左前降支诱导心肌梗死模型。观察假手术组（10只）、生理盐水组（13只）、对照病毒组（13只）、TK-1组（13只）、TIMP-1组（13只）、联合基因组（13只）的大鼠术后的心功能参数改变、心肌梗死面积、及各组大鼠基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）、核因子-κB（NF-κB ...
郑熙, 余惠珍, 高洁, 朱鹏立
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Journal of Diabetes, Volume 15, Issue 12, Page 1070-1080, December 2023., 2023 Highlights Lipid profiles of small extracellular vesicles (sEVs) in patients with diabetes or diabetic cardiovascular disease are rarely reported. n‐3 docosahexaenoic acid (DHA)‐enriched triacylglycerol (TG) was found to decrease in sEVs from serum of patients with diabetic cardiovascular disease (DM‐CAD).
Wei Ding +3 more
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Ultrasound in Obstetrics &Gynecology, Volume 60, Issue 1, Page 118-131, July 2022., 2022 ABSTRACT Objectives To evaluate whether the Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis need to be better defined and, if deemed necessary, to reach consensus on the updated definitions. Methods A modified Delphi procedure was performed among European gynecologists with expertise in ultrasound diagnosis of adenomyosis. To
M. J. Harmsen +17 more
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Ultrasound in Obstetrics &Gynecology, Volume 59, Issue 4, Page 437-449, April 2022., 2022 ABSTRACT Objective To develop a standardized sonographic evaluation and reporting system for Cesarean scar pregnancy (CSP) in the first trimester, for use by both general gynecology and expert clinics. Methods A modified Delphi procedure was carried out, in which 28 international experts in obstetric and gynecological ultrasonography were invited to ...
I. P. M. Jordans +18 more
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随着全球人口老龄化的加剧和生活方式的改变，T2DM及其并发症的发病率逐年上升。T2DM患者并发的肌少症（Sar）增加患者跌倒风险、住院风险和全因死亡率，是DM导致残疾的重要并发症。研究数据表明，T2DM合并Sar患病率达19%。尽管医学营养治疗能有效缓解糖尿病相关肌少症患者的病情，但仅靠此不足以改善该类患者的健康状况,且目前DM合并肌少症的药物治疗尚未达成明确共识。运动干预作为简便、有效的辅助治疗手段，已被证实对维持老年T2DM病人骨骼肌量和肌肉功能重塑具有较好的作用，可以很好地预防和治疗肌少症 ...
周雯明
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Developmental Medicine &Child Neurology, Volume 63, Issue 8, Page e1-e4, August 2021., 2021 目的 探討全基因體定序 (WGS) 對兒童神經疾病的診斷率及治療影響。 方法 從 2016 年 1 月至 2019 年 12 月, 使用全基因體定序對疑似患有遺傳性神經疾病的兒科病人進行評估。符合條件的病人依其臨床表現型分為四組: 神經發展障礙病人、癲癇病人、神經肌肉疾病病人及運動障礙病人。我們描述全基因體定序的診斷率及經全基因體定序確診後對病人治療的影響。 結果 共有 214 例病人 (男性 128 例, 女性 86 例) 接受了全基因體定序檢測, 病人平均 (SD) 發病年齡為 13.8 (27.6) 個月, 範圍為 1 天至 15 年 5 個月, 接受全基因體定序檢測的平均 (SD) 年齡為 71.7 (58.9) 個月, 範圍從 8 天到 18 歲。 43.9 ...
李 秀芬, 遲景 上, 蔡 啟仁
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Journal of Advanced Nursing, Volume 77, Issue 4, Page 1825-1838, April 2021., 2021 Abstract Aim To analyse the interactions of associated factors with post stroke fatigue (PSF) after discharge home and determine the predictors of PSF and their impact on stroke survivors. Design A prospective observational study. Methods A total of 94 patients with acute stroke were recruited between May 2019 ‐July 2020. The main outcomes were fatigue,
Ya Su +7 more
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Computational and Mathematical Methods in Medicine, Volume 2021, Issue 1, 2021., 2021 Using natural language processing (NLP) technologies to develop medical chatbots makes the diagnosis of the patient more convenient and efficient, which is a typical application in healthcare AI. Because of its importance, lots of researches have come out. Recently, the neural generative models have shown their impressive ability as the core of chatbot,
Ke Liang +3 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 评价岛状颏下肌皮瓣修复口腔口咽癌术后软组织缺损的临床效果65377; 【方法】 对2003年1月至2007年12月间采用岛状颏下肌皮瓣修复的58例口腔口咽癌术后缺损患者的临床资料进行随访分析,包括受区缺损情况65380;肌皮瓣大小65380;成活情况65380;术后并发症65380;外形和功能65380;癌肿复发以及患者的生存状态等多方面65377; 【结果】 全部患者安全度过围手术期65377;58例中的55例岛状颏下肌皮瓣完全成活,另3例肌皮瓣远心端边缘部分坏死,经修剪换药后愈合 ...
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Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
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