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Zhejiang Da Xue Xue Bao Yi Xue Ban肝炎病毒感染是肝细胞癌的主要致病因素之一。甲型肝炎病毒（HAV）通常引起急性感染，临床病理长期追踪结果显示HAV感染与肝细胞癌发生有一定联系。乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）的慢性感染可导致长期肝脏炎症和肝硬化，影响多条细胞凋亡和增殖相关信号通路，是病毒感染导致肝细胞癌的最常见诱因。HBV X蛋白（HBx）基因突变与肝细胞癌发病率密切相关，HCV核心蛋白的表达可导致肝细胞脂质积累，促进肿瘤发生。临床丁型肝炎病毒（HDV）感染常伴随HBV的共感染，从而增加慢性肝炎风险。戊型肝炎病毒（HEV ...
Ling-Dong Xu +4 more
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浙江大学学报. 医学版肝疾病中的炎症衰老作用机制和干预措施是当前研究的热点。炎症衰老是一种与慢性炎症相关的细胞功能衰退过程，广泛参与肝疾病的发生发展。对于病毒性肝炎，炎症衰老的机制主要涉及氧化应激、细胞凋亡和坏死以及肠道菌群失调。非酒精性脂肪性肝病中的炎症衰老机制较为复杂，涉及胰岛素抵抗和脂肪沉积、脂质代谢紊乱、肠道菌群失调以及NAD+代谢异常。肝脏肿瘤中的炎症衰老则表现为肿瘤抑制机制的减弱、肝脏微环境的重塑、代谢重编程以及免疫逃逸机制的强化。目前，针对炎症衰老的治疗策略正在逐步发展，抗氧化治疗 ...
徐 燕萍 +3 more
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International Journal of Immunogenetics, Volume 50, Issue 6, Page 299-305, December 2023., 2023 Abstract Hepatitis B virus (HBV) is responsible for various liver diseases, such as chronic hepatitis B (CHB), liver fibrosis, liver cirrhosis (LC) and hepatocellular carcinoma (HCC), which pose a significant threat to human health. An ineffective immune response to HBV can result in viral chronicity.
Hai Cheng +3 more
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Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023 Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee +7 more
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Journal of Diabetes, Volume 14, Issue 10, Page 695-710, October 2022., 2022 Highlights Electroacupuncture (EA) regulates the intestinal flora by promoting intestinal motility. EA regulated the intestinal flora to reduce the level of systemic inflammation. EA lowering the blood glucose by the IKKβ/NF‐κB‐JNK‐IRS‐1‐AKT signal pathway.
Jing An +7 more
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Journal of Diabetes, Volume 14, Issue 4, Page 247-260, April 2022., 2022 Highlights Phosphoinositide 3‐kinase (PI3K)/Akt signaling is an emerging promising therapeutic target for diabetes. Modulation of the PI3K/Akt signaling pathway, via protein and peptide‐based biologics, parasite‐derived molecules, plant extracts, or through microRNA interactions, will regulate the processes that determine the function of β‐cells and ...
Inah Camaya +2 more
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亚洲临床医学杂志, 2020 乙型肝炎病毒（Hepatitis B virus, HBV）感染呈全球流行趋势，据统计全世界有将近 20 亿人曾经感染 HBV，慢性携带者更是高达 2.5 亿人。中国是 HBV 的一个高发国家，有近 9000 万慢性 HBV 携带者，乙型肝炎感染慢性化是由于被感染的肝细胞核内 HBV ccc DNA 的存在。但是在临床诊断上依旧以实验室检查为主，影像学检测对肝纤维化程度以及疾病的评估和预后判断有重要的价值。近几年研究显示检测 HBV cccDNA 可对疾病的安全停药以及临床治愈提出可靠的病毒学指标 ...
伟 王, 纪红 安
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The psychometric properties of the quick inventory of depressive symptomatology-self-report (QIDS-SR) in patients with HBV-related liver disease [PDF]
, 2017 Background: Comorbid depression in Hepatitis B virus (HBV) is common. Developing accurate and time efficient tools to measure depressive symptoms in HBV is important for research and clinical practice in China.
Duan, Zhong-ping +7 more
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, 1993 Relationship between ethanol drinking and organs injury was reviewed and special emphasis was put on alcoholic liver disease. Consumption of alcoholic beverage expressed as ethanol per capita of adult in Japan increased 2.1 times in these 25 years and it
Endo, Hiroshi +4 more
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