【目的】 探讨硒化麒麟菜多糖在体外对肝癌HepG2.2.15细胞株生长和凋亡的作用及机制?【方法】 处于生长期的人肝癌细胞HepG2.2.15分为3组,对照组?硒化麒麟菜多糖组和顺氨氯铂组?用MTT法检测各组肿瘤细胞增殖的情况,流式细胞仪检测细胞周期?细胞调亡以及凋亡基因Fas的表达情况?【结果】 硒化麒麟菜多糖在体外可抑制肿瘤细胞的增殖,最高抑制率为97.2%,并且有时间依赖性?硒化麒麟菜多糖可阻滞肝癌HepG2.2.15细胞的生长使之停留在S和G2/M期,从而抑制了肿瘤细胞的增殖 ...
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