Receptor discordance between primary breast cancer and liver metastases [PDF]
, 2023 Background and purpose: Systematic treatment for breast cancer largely depends on the status of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2).
JIN Yizi, LIN Mingxi, ZHANG Jian
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Research progress on the mechanism of organ-specific lung metastasis in pancreatic cancer [PDF]
, 2023 Pancreatic cancer is a highly malignant tumor of the digestive system. Due to the non-specific clinical symptoms in the early stage, its early diagnosis is very difficult.
YUE Ming, WANG Liwei, CUI Jiujie
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Analysis of efficacy of hepatectomy and prognostic risk factors in patients with gastric cancer with synchronous liver metastasis [PDF]
, 2023 Background and purpose: Whether patients with gastric cancer with synchronous liver metastases (GCLM) receive hepatectomy remains controversial. In this study, we analyzed the clinicopathological characteristics and treatment modalities of patients with ...
ZOU Ting, LIU Xiaowen
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Effect of tRF-Pro-CGG on the biological behavior of mouse pancreatic cancer cells and its molecular mechanism [PDF]
, 2023 Background and purpose: tRNA-derived fragments (tRF) are a kind of short non-coding RNA (14-30 nt) that influences the course of cancer. This study aimed to investigate the molecular pathways that might underlie the effects of tRF-Pro-CGG on the ...
FU Qingsheng, JIN Lei, ZHANG Xudong, XU Yingchen, ZHU Chunfu, QIN Xihu, WU Baoqiang
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Clinical features and prognosis in patients with lung metastases from colorectal cancer [PDF]
, 2017 目的探讨结直肠癌肺转移患者的临床特征及预后生存分析。方法选取2008年1月至2014年1月间福建医科大学附属第一医院收治的146例结直肠癌肺转移患者的临床资料及随访资料,分析患者的临床特征及影响结直肠癌肺转移患者预后的相关因素。结果患者中位随访时间为35.1个月,中位生存时间为27.1个月,1年、3年和5年生存率分别为75.3%、30.8%和12.4%。病理组织分级、TNM肿瘤分期、肺转移灶大小、肺转移灶数目、是否合并肝转移和治疗方式不同的结直肠癌肺转移患者,预后生存时间差异均有统计学意义（均P〈0 ...
傅启全, 凌浩, 董长女
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Zhongshan Daxue xuebao. Yixue kexue ban, 2022 目的既往有多个报道结直肠癌转移方式的研究，但尚缺少基于长期随访并以死亡作为观察终点，总结CRC转移部位、发生率以及相关生存数据的研究。方法本研究回顾中山大学附属第六医院373例结直肠癌死亡患者资料，统计分析肿瘤转移的部位、发生率以及生存资料。结果334例（89.5%）患者为肿瘤相关性死亡，肝转移率为51.5%，肺转移率为40.4%，腹膜转移率为55.7%。单纯肝、肺、腹膜转移患者数分别为27例（8%）、21例（6.3%）、63例（18.9%）。单纯肺转移患者生存明显优于单纯肝转移或单纯腹膜转移（P<
周家铭 +7 more
doaj
Automatic Generation of Electronic Medical Record Based on GPT2 Model [PDF]
, 2019 Writing Electronic Medical Records (EMR) as one of daily major tasks of doctors, consumes a lot of time and effort from doctors. This paper reports our efforts to generate electronic medical records using the language model.
Bai, Xuming +6 more
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Chinese expert consensus on clinical application of recombinant oncolytic adenovirus in the treatment of malignant tumors [PDF]
, 2023 Treatment using oncolytic virus as a new tumor immunologic agent has made continuous breakthroughs in basic and clinical research of tumor in recent years, and it is expected to play an important role in cancer immunotherapy in the future.
Expert Committee on Immunotherapy of Chinese Society of Clinical Oncology , Professional Committee on Cancer Biotherapy of Shanghai Anticancer Association
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Curative Effect of EGFR-TKIs with Anti-angiogenic Drugs as the Treatment for Patients with Advanced EGFR-mutant Non-small Cell Lung Cancer：a Meta-analysis [PDF]
, 2022 BackgroundAcquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) will eventually occur in almost all advanced EGFR-mutant non-small cell lung cancer (EGFR-mutant NSCLC) patients although the therapy has been a ...
LI Yong, LONG Yong, ZHAO Chong, ZHANG Guanqing, SU Yanhe
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Functions of Periostin in the Hepatic Microenvironment of Metastatic Colorectal Cancer [PDF]
, 2017 结直肠癌肝转移是导致结直肠癌患者死亡最重要的因素之一。有文献报道Periostin（POSTN）蛋白可以加剧肝脏的纤维化，也有文献表明POSTN可以促进结直肠癌肝转移，但对该蛋白是否在肝转移微环境的重塑过程中行使功能则并不清楚。在本研究中，我们发现脾内注射的结直肠癌细胞在形成肝转移灶的过程中α-SMA、胶原蛋白I、胶原蛋白III和TGF-β1这些纤维化的标志物以及POSTN的表达量都发生了显著上调，表明结直肠癌细胞诱导了肝纤维化微环境的形成 ...
范传楠
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