Updates on precision medicine of pancreatic neuroendocrine tumor [PDF]
, 2023 Since the concept of precision medicine proposed in 2011, the treatment of solid tumors has entered era of precision medicine led by gene testing. As a rare tumor, the incidence rate of pancreatic neuroendocrine tumor (PanNET) is increasing gradually. In
GAO Heli, XU Jin, CHEN Jie, YU Xianjun
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Cyclin Dependent Kinase 5 promotes invasion and metastasis of Hepatocellular Carcinoma [PDF]
, 2016 肝细胞癌（HepatocellularCarcinoma，HCC）在所有恶性肿瘤导致的死亡原因中占第三位，其发病率居恶性肿瘤的第六位。肝癌具有的高复发以及高转移，使肝癌愈后很差，而导致肝癌高复发和高转移的机制还不是很清楚。最近研究表明细胞周期蛋白激酶家族蛋白在上述调控过程中具有重要作用。 细胞周期素依赖蛋白激酶家族中的一个特殊蛋白：细胞周期素依赖蛋白激酶5（CyclinDependentKinase5，CDK5）引起了我们的注意，CDK5被认为主要在神经系统发挥作用。但是 ...
赵文兴
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A Clinical Observation of Concomitant Therapy of Erlotinib and Whole Brain Radiotherapy in Patients of NSCLC Combined with Brain Metastases [PDF]
, 2009 Background and objective Treatments to brain metastases in patients of NSCLC include operation, chemotherapy and radiotherapy, while the disease control rate of brain lesions is not so good, the media survival time is 4-6 months.
Jing ZHAO, Lihong ZHANG, Qiang FU
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Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer [PDF]
Liver is the common site for metastasis and spread of non-small cell lung cancer (NSCLC). Lung cancer patients with liver metastasis have poor prognosis, which may be related to liver-specific microenvironment composition.
SUN Jiaqi, WANG Yudong
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The value of surgery in the patients with de novo stage Ⅳ breast cancer [PDF]
, 2023 Breast cancer is one of the common malignant tumors in the world. About 6% of the patients are de novo stage Ⅳ breast cancer, which is incurable. Traditionally, the role of surgery has been confined to relieving symptoms, improving quality of life and ...
CHEN Luyan, WANG Lixue, FU Peifen
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Zhongguo shiyan zhenduanxue, 2018 目的探讨血清miR-21对结直肠癌肝转移预测的诊断价值,以期为临床的结直肠癌肝转移的预测提供一种潜在的辅助诊断方法。方法检测146例晚期结直肠癌无肝转移患者和124例晚期结直肠癌伴肝转移患者血清中CEA的含量和miR-21的相对表达值,评价其单独检测和联合检测对于结直肠癌肝转移的预测的诊断价值。结果与结直肠癌无肝转移组相比,结直肠癌伴随肝转移组的CEA和miR-21均显著升高 ...
肖霞, 马慧, 王欣
doaj
Effects of all trans relinoic acid on the liver metastatic model of gastric cancer cells, BGC-823 and MKN-45 [PDF]
, 2000 目的 研究全反式视黄酸 (ATRA)对胃癌细胞实验性肝转移能力的影响。方法 将胃癌细胞BGC 82 3和MKN 45注射于裸小鼠脾包膜下 ,隔日给裸小鼠灌服ATRA。术后 6周处死裸小鼠 ,解剖脾脏及肝脏肿瘤并用免疫组织化学方法测定其肿瘤血管密度 ;以放射免疫法测定血清癌胚抗原 (CEA)。结果 ATRA抑制胃癌细胞脾包膜下移植瘤的生长及其肝转移 ,抑制率分别为 5 0 .0 %(BGC 82 3)和 33.3% (MKN 45 ) ;使脾移植瘤和肝转移瘤的肿瘤血管密度降低 ...
吴乔 +4 more
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Zhongguo shiyan zhenduanxue, 2017 目的分析晚期胰腺癌患者血清CEA,CA199水平与肝转移的关系,探讨胰腺癌肝转移的危险因素。方法选取101例胰腺癌患者,主要根据有无肝转移分组,肝转移70例,无肝转移31例。采用化学发光免疫法对其血清标本中癌胚抗原（CEA）、糖抗原19-9（CA19-9）、糖抗原125（CA125）、糖抗原72-4（CA72-4）、细胞角蛋白21-1（CYFRA21-1）等项目进行检测。结果血清CA19-9、CA125水平的增高与胰腺癌肝转移具有相关性 ...
杨柳, 闫欢, 石燕, 戴广海
doaj
Application progress of Yttrium-90 microsphere selective internal radiation therapy on metastatic liver cancer [PDF]
Yttrium-90 microsphere selective internal radiation therapy (90Y-SIRT) has been widely used in the treatment of malignant liver cancers, and its safety and efficacy have been fully validated.
Guanxiang ZHUO +3 more
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Effects of systemic and interventional chemotherapy with CPT-11 + xeloda for the liver metastasis from colorectal carcinoma [PDF]
, 2007 目的:评价开普拓+希罗达方案(XELILI方案)介入及全身化疗治疗大肠癌肝转移的疗效及毒副作用。方法:病理确诊的大肠癌患者50例,其中45例为根治术后FOLFOX4方案化疗后出现肝转移,5例为初治者。术前常规检查除外治疗禁忌症并CT扫描测量肝转移灶大小,予以开普拓+希罗达方案介入栓塞化疗序贯全身化疗,开普拓用量:180mg/m2,碘化油10ml～20ml,希罗达2000mg/m2,分两次口服,连服14天,休息7天,21天一周期。2周期后复查血常规、肝肾功能、腹部CT,判断疗效及是否进一步介入治疗 ...
吕霞 +4 more
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