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AKT1基因PH结构域在亚洲胃肠道肿瘤中的变异研究

Zhongguo shiyan zhenduanxue, 2010
目的分析AKT1基因PH（the pleckstrin homology,PH）结构域第4外显子的碱基序列,探讨中国人和日本人AKT1基因突变与胃肠道肿瘤的关系。方法采用激光显微切割技术捕获胃癌组织和大肠癌组织的肿瘤细胞,以这些标本的基因组DNA为模板,用聚合酶链反应PCR方法扩增AKT1基因PH结构域,PCR产物经纯化后直接测序。结果分析测序图发现AKT1基因PH结构域第4外显子第49核苷酸没有出现点突变。结论中国人和日本人的胃肠道肿瘤的AKT1基因PH结构域没有出现点突变 ...
李玉琴, 孙泯丹, 李丽娜, 田中康雄, 小俣政男   +4 more
doaj  

[Variations in fecal microbiota of first episode schizophrenia associated with clinical assessment and serum metabolomics]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban, 2022
Wang XP, Zhang YY, Lu TL, Lu Z, Kang ZW, Sun YY, Yue WH.   +6 more
europepmc   +1 more source

[Differences in Oral and Gut Microbiome Composition Among Preschool Children in Urumqi During the Deciduous and Mixed Dentition Periods]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Ma T, Lian B, Wu Z, Zhao J.
europepmc   +1 more source

[Research progress on the relationship between gut microbiota and childhood bronchial asthma]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Yu L, Wu ML, Zheng XR.
europepmc   +1 more source

[<i>Poria cocos</i> polysaccharide alleviates cyclophosphamide-induced intestinal barrier dysfunction and inflammation in mice by modulating gut flora]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhang Y, Duan Y, Zhang C, Yu L, Liu Y, Xing L, Wang L, Yu N, Peng D, Chen W, Wang Y.   +10 more
europepmc   +1 more source

青春期启动与肥胖相关的研究进展

Zhongguo shiyan zhenduanxue
青春期发育启动年龄呈现提前的趋势，性早熟与超重、肥胖的患病率之间呈现平行上升趋势。青春期启动提前与肥胖存在流行病学关联和发病机制的关联，其关联机制是当前关注热点之一。研究表明，肥胖与青春期启动可通过神经内分泌、肠道微生物及其代谢物、遗传等多方面相互影响，具体机制可涉及瘦素、脂联素、胰岛素及其受体、高雄激素血症、性早熟相关基因、母体及孕期因素和肠道微生物群等。该文基于上述多种因素概述了青春期启动与肥胖的相关研究进展，为进一步探讨性早熟、肥胖等相关疾病的发生机制及防治提供参考。
杨丹
doaj  

Interplay between gut microbiota and intestinal lipid metabolism:mechanisms and implications. [PDF]

J Zhejiang Univ Sci B
Hang B, Wang Y.
europepmc   +1 more source

[Comparative Analysis of Oral and Gut Microbiota Composition in Children Aged 3-5 Years With Different Body Mass Indexes in Urumqi]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Ma T, Wu Z, Lian B, Zhao J.
europepmc   +1 more source

Impacts of pancreatic exocrine insufficiency on gut microbiota. [PDF]

J Zhejiang Univ Sci B
Guo Y, Cao F, Li F.
europepmc   +1 more source

[Pentosan polysulfate alleviates cyclophosphamide-induced interstitial cystitis/bladder pain syndrome in mice by modulating gut microbiota and bile acid metabolism]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhu Y, Zhu Z, Wu P.
europepmc   +1 more source