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mTOR信号通路调控非酒精性脂肪性肝病的研究进展

Zhongguo shiyan zhenduanxue
非酒精性脂肪性肝病(Non-Alcoholic Fatty Liver Disease, NAFLD)是以肝脏脂质沉积过多为主要特征并伴有不同程度的炎症和损伤的一种临床病理综合征。NAFLD与酒精摄入无关，通常与肥胖、糖尿病、高血压和高血脂等代谢综合征相关。目前为止，我国大陆地区患病率约为29.81%高于全球的平均水平(25%),NAFLD已经超越乙型病毒性肝炎和酒精性肝病，成为中国最常见的慢性肝病。NAFLD在早期通常没有明显的症状，
张玉秀, 姚睿原, 孙传凯, 吴璟玥, 包丽丽   +4 more
doaj  

[Association Between Obesity and the Risk of Obstructive Sleep Apnea Combined With Hypertension]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Zhao X, Shu M, Li X, Peng L, Zhang X.
europepmc   +1 more source

[Aerobic exercise regulates macrophage polarization and improves insulin resistance in mice: the mediating role of miR-221-3p]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Li N, Zhang L, Guo Q, Zhou Y, Liu C.
europepmc   +1 more source

针对阿片类药物和胆石病因果关系的新见解：一项两样本孟德尔随机化研究

Zhongguo shiyan zhenduanxue
胆石症困扰着全球约10%～20%的成年人，影响了患者的生活质量，加重了经济负担[1]。胆石症的危险因素包括肥胖、糖尿病，胆囊动力障碍等[2]。阿片类药物是临床实践中常用的一组镇痛药，广泛应用于全身麻醉的诱导、维持及围术期镇痛治疗[3-5]。然而，滥用阿片类药物可能导致成瘾和其他严重的健康风险，如呼吸抑制[6-7]。新近有研究报道：阿片类药物可能是胆石症发生的一项影响因素[8]。与随机对照实验（RCT）方法对比，孟德尔随机化（MR ...
于馨洁, 潘振祥
doaj  

[Shared Therapeutic Targets of Obesity and Type 2 Diabetes Mellitus and the Intervention Mechanisms of Chinese Herbal Components]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Li R, Wang R, Li L, Wang C, Liao T, Zhang B, Yue R.   +6 more
europepmc   +1 more source

[Association of Obesity Phenotypes With Cognitive Impairment and Genetic Stratification Analysis in Older Chinese Adults]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Chen X, Yan H, Zhao Q, Yang N, Xu B, Liao J, Jiang X, Li J.   +7 more
europepmc   +1 more source

[Advances in research on metabolic associated fatty liver disease in 2025]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Rao HY, Zhao JM, Yu CH, Mi YQ, Wei L.
europepmc   +1 more source

[Research Advancements in Gastric Capacity Intervention for Childhood and Adolescent Obesity]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Zhou A, Yang F.
europepmc   +1 more source

[Comparative Analysis of Oral and Gut Microbiota Composition in Children Aged 3-5 Years With Different Body Mass Indexes in Urumqi]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Ma T, Wu Z, Lian B, Zhao J.
europepmc   +1 more source

[Strategies for Weight Management in Children and Adolescents: Self-Regulated Nutrition, Family-School Collaboration, and Social Environment Optimization]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Wang X, Xu Y, Xiong J, Cheng G.
europepmc   +1 more source