Sotatercept and pulmonary arterial hypertension. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban肺动脉高压是一类以肺动脉压力升高为特征，最终可导致患者右心衰竭甚至死亡的慢性进行性疾病。动脉型肺动脉高压的主要病理机制是肺小动脉血管重构引起肺血管阻力升高。目前，治疗动脉型肺动脉高压的靶向药物其主要机制是扩张肺动脉，改善血流动力学参数，提高患者生存质量，但仍无法从根本上有效地逆转肺血管重构，达到治愈目的。Sotatercept是全球首个靶向治疗动脉型肺动脉高压的生物制剂，能恢复促增殖和抗增殖信号通路之间的平衡，从而逆转肺血管重构 ...
Tan Y, Chen Y, Li J.
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Methods for establishing animal models of persistent pulmonary hypertension of the newborn: A systematic literature analysis. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban目的 新生儿持续性肺动脉高压(persistent pulmonary hypertension of the newborn，PPHN)发病机制复杂，疾病危险因素尚未完全阐明，构建符合PPHN病理生理特征的动物模型对研究其发病机制和治疗方法具有重要意义。本研究旨在通过系统性文献检索，总结并分析PPHN动物模型的应用领域、造模要素及成模标准，以期为建立科学规范且经济易行的动物模型提供参考。 方法 在中文数据库(中国知网、万方、维普和中国生物医学文献服务系统)及英文数据库(PubMed、Web of ...
Cai M, Zhou S, Luo P, Hu C, Sun L.
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[Quercetin improves pulmonary arterial hypertension in rats by regulating the HMGB1/RAGE/NF-κB pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Zhang N +7 more
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Clinical characteristics and risk factors for primary Sjögren's syndrome complicated with pulmonary arterial hypertension. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Chen Z, Tian J, Ouyang R.
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Effect of hepatocyte growth factor on mice with hypoxic pulmonary arterial hypertension: a preliminary study. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2022 Tang HT, Mu WH, Xiang YJ, An Y.
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[Application of extracorporeal membrane oxygenation in the treatment of persistent pulmonary hypertension of the newborn]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2022 Chen YL +6 more
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[Effect of platelet-derived growth factor-BB on pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension and its mechanism]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2023 Guo X, Li MX, Bayer C, Yang YQ, Wang L.
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Efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn: a Metaanalysis. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2022 Li LX, Wei B, Yang M, Li M, Jia JJ.
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Pulmonary hypertension complicating mediastinal fibrosis secondary to tuberculosis: A case report and literature review. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Zong D, Ouyang R.
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Association of asymmetric dimethylarginine with the pathological process of persistent pulmonary hypertension of the newborn. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2022 Zhang WT, Lu Q, Ding JJ, Gu M.
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