Zhongshan Daxue xuebao. Yixue kexue ban动脉型肺动脉高压（PAH）是一种慢性进展性心肺疾病，其主要病理改变是血管收缩和肺动脉增生性重构以及右心室肥厚引起肺动脉压力持续升高。深入探究PAH发病机制可以发现，其相关途径有血管增生、血管壁重构、氧化应激、炎症反应与基因调控等。虽然近年来PAH在治疗方面取得很大进展，但其死亡率仍然很高，当前临床治疗方法并未有效改善预后，该病对患者身体、社会、工作和情感等方面产生了很大影响。本文将对PAH治疗方面最新研究进行综述，以期为PAH临床治疗提供新的线索。
王士伟, 康龙丽
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肺活检在先天性心脏病合并肺动脉高压的外科临床应用 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 1991 先天性心脏病合并肺动脉高压的外科疗效众说纷纭,作者就肺活检定量与定性分析肺血管病变进行比较。在研究组30例先心病并肺高压与对照组11例的重复分析结果表明;“移行段”肺小动脉壁中层厚度定量分析比Heath-Edwards定性分析优越,与临床手术疗效相关性好,可重复性高、与肺动脉及动脉收缩压之比等的血流动力学指标相关性好。作者推荐经电脑分析的以心导管指标反映定量活检的方程:M％=2.54+8.69(Pp/Ps)+0.23(Rp)-0.04(DPA),以及国人“移行段”肺小动脉中层厚度的分析标准,供临床参考。
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Effect of overexpression of microRNA-124 on pulmonary vascular remodeling in rats with pulmonary arterial hypertension [PDF]
, 2023 Objective To evaluate the effect of overexpression of microRNA-124 （miR-124） on pulmonary vascular remodeling， and to unravel the potential mechanism in rats with pulmonary arterial hypertension （PAH）.
Zhu Jian, Chen Tiantian, Liu Zhiyong, Zheng Changlong
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Evaluation of Cardiac Structure and Function in Patients with Wilson Disease Based on RT-3DE: a Clinical Study [PDF]
, 2023 Background Wilson disease (WD) is a rare autosomal recessive disease that causes impaired copper excretion, mainly manifestedashepatic and/or neuropsychiatric symptoms, but diversifies with the varying affected organs and severity of the disease.
ZHANG Yu, WANG Meixia, ZHANG Jing, WANG Fei, LI Zhonglei, ZHANG Yanyun, JIANG Zhenzhen
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Effect of potential pathogenic gene PDX1 variants of total anomalous pulmonary venous connection on its gene function [PDF]
, 2023 Objective·To explore the possible pathogenic gene of total anomalous pulmonary venous connection (TAPVC) by whole exon sequencing and verify its function.Methods·One hundred TAPVC children (case group) and one hundred and twenty healthy children (control
FENG Weiqi +4 more
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, 2017 目的应用超声心动图（UCG）评价动脉导管未闭（PDA）经介入封堵术与外科结扎术治疗前后心脏结构及功能的变化,指导临床决策。方法选取96例经介入封堵治疗（封堵组）与89例经外科结扎治疗（结扎组）的PDA患者行UCG常规检查,分别比较手术前后不同时间段心脏结构、功能的变化,肺动脉压力的变化,有无残余分流等情况。结果封堵组与结扎组术后除主动脉内径（AOD）外,心脏各参数术后明显得到改善（P〈0.05）。两组术后均有左室射血分数（LVEF）异常下降情况发生。与结扎组相比 ...
李金国, 沈梦茜
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Prediction Methods of Exercise Induced Desaturation Detected by Six-minute Walk Test in Patients with Stable Chronic Obstructive Pulmonary Disease [PDF]
, 2022 BackgroundExercise-induced desaturation (EID) is highly prevalent, and associated with the prognosis in patients with chronic obstructive pulmonary disease (COPD) .
YANG Lulu, QUMU Shiwei , SITU Xuanming, HE Jiaze, YANG Ting
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Crosstalk between epigenetic modification and circRNA in colorectal cancer: recent advances [PDF]
, 2023 Colorectal cancer (CRC) is generally regarded as the third frequent malignancy worldwide, while current diagnosis and treatment of the disease are limited.
PENG Tian, XU Leiming
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Structure Analysis and Characterization of Aminorex Analogue 4’-F-4-MAR [PDF]
, 2020 Objective To study the identification method for 4’-F-4-methylaminorex（4’-F-4-MAR） in samples without reference substance. Methods Gas chromatography-mass spectrometry （GC-MS）, ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass ...
LIU Cui-mei, HUA Zhen-dong, JIA Wei
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TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells [PDF]
, 2016 溶血卵磷脂（lysophosphatidylcholine，lysoPC）是氧化低密度脂蛋白（oxidizedlow-densitylipoprotein，ox-LDL）的主要成分。早期的研究表明，lysoPC可诱导人冠状动脉平滑肌细胞（humancoronaryarterysmoothmusclecells，HCASMCs)凋亡，但具体机制尚不清楚。近期，我们通过细胞活力测定，流式细胞术，共聚焦显微镜及分子生物学手段对lysoPC作用的分子机制进行研究发现，lysoPC可引发细胞外钙离子内流 ...
王渊
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