Association between Subclinical Hypothyroidism and Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus [PDF]
, 2022 BackgroundCardiac autonomic neuropathy (CAN) is a common and severe chronic diabetic complication, whose association with thyroid function has rarely been reported.ObjectiveTo investigate the association between subclinical hypothyroidism and CAN in type
ZHAO Lei, LI Ruqiang, YUAN Mingxia
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Predictive Value of Serum Uric Acid in Perioperative Acute Ischemic Stroke in Patients with Non-small Cell Lung Cancer [PDF]
, 2023 Background Perioperative acute ischemic stroke (POAIS) is a severe complication of surgery, which can increase surgical mortality and reduce patients' quality of life. The pathogeneses are complex and rarely explored, especially in patients with non-
BAI Haiwei, MI Xiaokun, LIU Qingrui, ZHU Lin, WANG Yingnan, LIU Junyan, HAN Ying
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老年脓毒症诱发急性肾损伤患者血清NGAL、CysC水平变化及诊断价值研究
Zhongguo shiyan zhenduanxue, 2020 急性肾损伤(AKI)为脓毒血症(sepsis)常见的并发症,发病率高达30%-50%[1],患者临床表现仅为少尿或无尿,血肌酐轻度上升,尤其老年患者,临床症状体征更不明显[2]。中性粒细胞明胶酶相关载脂蛋白(NGAL)为最初在激活的中性粒细胞中发现的一种小分子量的分泌蛋白质,近年研究显示[3]NGAL是患者肾小球滤过率降低时敏感指标。胱抑素(CysC)仅通过肾小球滤过而被清除 ...
许慧慧, 吴维雄, 于航, 谢承志
doaj
Influencing factors of IgA nephropathy combined with hyperuricemia and a nomogram to predict the risk of hyperuricemia in IgA nephropathy patients [PDF]
ObjectiveTo investigate the factors influencing the complication of hyperuricemia （HUA） in patients with immunoglobulin A nephropathy （IgAN） and to construct a nomogram to predict it.MethodsFrom December 1， 2020 to December 1， 2023， 332 IgAN patients ...
Li Ji-tian +3 more
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TGF-β1/SMAD在糖尿病肾病中的作用机制与研究进展 [PDF]
, 2023 Diabetic nephropathy (DN) is a common complication of diabetes and a leading cause of end-stage renal disease. Transforming growth factor-β1 (TGF-β1)/SMAD signaling activation plays an important role in the onset and progression of DN.
Chen, Haiyong +4 more
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The effect of pentosan polysulfate on diabetic nephropathy renal tubular epithelial cells injury through regulating p38 MAPK signaling pathway [PDF]
, 2016 目的：观察戊糖多硫酸钠是否通过调控P38MAPK干预糖尿病肾病肾小管上皮细胞的损伤。方法：利用不同浓度（10mmol/L～50mmol/L）葡萄糖刺激肾小管上皮细胞（HK-2）48h，应用CCK-8比色法检测肾小管上皮细胞增殖的改变。利用不同时间段（0h～48h）葡萄糖刺激细胞，用Westernblot法检测P38MAPK蛋白的表达水平。分为正常对照组（control组）、高糖组（HG组，葡萄糖30mmol/L)、戊糖多硫酸钠（PPS）组（PPS200µg/mL)、高糖＋戊糖多硫酸钠组（HG＋
张天英
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Effects of Cinacalcet HCl on Secondary Hyperparathyroidism and Renal Injury in the Uremic Rat [PDF]
, 2016 目的 慢性肾脏病患者随着肾脏功能的逐渐减退，早期即可出现钙磷失衡、维生素D缺乏、甲状旁腺激素以及成纤维生长因子FGF23的升高，而这种矿物质代谢紊乱又可促使患者出现继发性甲状旁腺功能亢进以及加重肾脏损伤。目前CaSR激动剂作为有效抑制甲状旁腺增生的临床药物，适用于已发生SHPT的透析患者，为探究其是否也能防治继发性甲状旁腺亢进、矿物质代谢紊乱及肾脏损伤，本研究通过5/6肾大部切除术结合高磷饮食建立尿毒症大鼠模型，分别在造模成功早期预防性给予大鼠西那卡塞干预以及在大鼠慢性肾衰确立后给予盐酸西那卡塞干预 ...
孙青宜
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Correlation between serum homocysteine level and clinicopathological factors of IgA nephropathy [PDF]
ObjectiveTo investigate the correlation between serum homocysteine （Hcy） and clinicopathologic factors of immunoglobulin A nephropathy （IgAN）.MethodsA total of 349 patients with IgAN diagnosed by renal biopsy in the Nephrology Department of Longhua ...
Cai Xiao-fan +5 more
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Calcitriol inhibits advanced glycation end product (AGE)-elicited mesangial cell damage by sequestrated RAGE-NF-κB Signaling [PDF]
, 2015 维生素D是通过与骨，甲状旁腺，肾脏和胃肠道的相互作用调节钙稳态，已经被用来作为糖尿病肾病（DKD）的常规用药。几个临床试验表明，维生素D在糖尿病肾病的治疗中，存在着减少蛋白尿和减缓肾损伤的抗炎作用，但其作用机制尚不清楚。而晚期糖化终产物（AGEs）在血浆和肾的积累，在糖尿病肾病中，是大家公认的促炎症分子。为了探索这种抗炎作用，我们设计实验。 研究目的：探寻骨化三醇减少AGEs引起的人肾系膜细胞炎症反应的机制，具体是探寻骨化三醇对AGEs引起的人系膜细胞表达白细胞介素-6（IL-6）和单核细胞趋化因子 ...
刘波
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The effect of pentosan polysulfate on hyperglycemia stimulated apoptosis HK-2 cell by inhibiting p38MAPK signaling pathway [PDF]
, 2017 目的：研究戊糖多硫酸钠（PPS）通过调控p38MAPK信号通道干预高糖对肾小管上皮细胞（HK-2）损伤的分子机制。 方法：（1）利用含不同浓度（5.5mmol/L、15mmol/L、25mmol/L、30mmol/L）葡萄糖的培养基刺激肾小管上皮细胞（HK-2）48h，再用不用浓度（50μg/mL、100μg/mL、150μg/mL、200μg/mL）戊糖多硫酸钠预处理后的HK-2细胞给予30mmol/L糖浓度的刺激，应用CCK-8比色法检测HK-2细胞生长的改变情况。（2）利用30mmol ...
袁洋
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