Results 21 to 30 of about 1,152 (153)
Relationships of Skin AGEs and Serum CN-1 with Microvascular Complications in Type 2 Diabetes Mellitus [PDF]
, 2022 BackgroundHyperglycemia plays a significant role in the development and progression of diabetic complications. While carnosine is a putative scavenger of advanced glycation end products (AGEs) , its availability in tissue is limited by the activity of ...
YANG Guang, XU Xin, ZHANG Yu, XU Juan, JIANG Shujuan, XIA Li, ZHANG Yang, WANG Yikun, LI Zhongsheng, ZHANG Shiqi
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Critical Left Ventricular Ejection Fraction and Its Possible Pathogenesis in STEMI Patients with Supra-normal Ejection Fraction after Primary PCI [PDF]
, 2022 BackgroundLeft ventricular ejection fraction (LVEF) is often used as an assessment indicator for left ventricular systolic function. As adverse events occur in some patients with preserved LVEF, other phenotypes based on LVEF may exist in the population ...
HAO Xiao, ZHAO Mei, LI Shuren
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Application of evolocumab in patients with coronary heart disease complicated with mild renal insufficiency [PDF]
, 2023 Objective To evaluate the efficacy and safety of evolocumab， a proprotein convertase subtilisin/kexin type 9 （PCSK9） inhibitor， in lowering LDL-C levels in patients with coronary heart disease complicated with mild renal insufficiency.
Zhang Yu, Wu Bin, Feng Jiaxu, Wang Rutao, Yuan Ming
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Journal of Diabetes, Volume 12, Issue 5, Page 406-416, May 2020., 2020 Highlights In patients with hypertension and diabetes, early detection and intervention of insulin resistance and related risk factors in patients with normal BMI may reduce the occurrence of urinary microalbumin and delay the progression of CKD. Abstract Background The relationship between albuminuria and insulin resistance (IR) has not been clarified
Shi Gu +4 more
wiley +1 more source
Influencing Factors of Glycemic Variability in Type 1 Diabetes Patients [PDF]
, 2022 BackgroundThe prevalence of T1DM (type 1 diabetes) is increasing year by year, and its autoimmunity can easily lead to the destruction of pancreaticβcells and insulin deficiency, making blood glucose difficult to reach the target.ObjectiveTo ...
HE Yan, ZHAO Songqing
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EZSCAN风险评分在肾功能轻度损伤人群中的筛查价值 [PDF]
, 2023 目的自主神经功能障碍是慢性肾脏病（CKD）患者常见严重的并发症，且在CKD早期就会发生。汗腺功能障碍已被视为自主神经功能紊乱的初始组成部分。通过反向离子电渗疗法和计时电流法测量电化学皮肤电导（ESC）来评估汗腺功能，可能会检测出健康体检人群中轻度肾功能不全的患者，以便给予早期干预与治疗，延缓肾功能进一步恶化。方法EZSCAN分数 （0~100） 是基于计时电流分析的专有算法计算得出的。本研究入组了2020年1月至10月浙江大学医学院附属第二医院体检中心健康体检的6 661名受试者，包括肾功能下降 ...
孙婷, 沈国丽, 蔡如意, 邵敏
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糖尿病肾病（DKD）是指由糖尿病导致的慢性肾脏疾病，受遗传和环境因素及其相互作用的影响，是慢性肾脏病和终末期肾病的主要病因。小檗碱（BBR）是一种天然的异喹啉生物碱。近年来研究发现，BBR具有降血糖、降血脂、抗氧化、抗炎及抗纤维化作用，可以有效改善DKD的肾脏损害，其作用机制可能包括：改善糖脂代谢、减轻氧化应激、减轻炎症反应、改善肾脏纤维化、调控DNA甲基化、改善线粒体功能、调节肠道菌群，改善肠道代谢及清除功能。本文系统性综述了BBR治疗DKD的作用机制的研究现状 ...
曲柄衡, 童晓鹏
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Research progress on elderly-onset inflammatory bowel disease [PDF]
, 2023 Inflammatory bowel disease （IBD） is a group of chronic nonspecific intestinal inflammatory diseases with unknown etiology. It has been found that approximately 10%-20% of IBD occurs in old age. At present， the prevalence and quantity of elderly-onset IBD
Lin Jue, Zhi Min, Zhang Min
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Journal of Diabetes, Volume 11, Issue 12, Page 971-981, December 2019., 2019 Highlights This post hoc analysis of the GetGoal‐O trial suggests that add‐on therapy with lixisenatide in non‐frail patients aged ≥70 years with type 2 diabetes uncontrolled on basal insulin is safe and well tolerated and should be considered in this patient population as an alternative to rapid‐acting insulin.
George E. Dailey +4 more
wiley +1 more source
TGF-β1/SMAD在糖尿病肾病中的作用机制与研究进展 [PDF]
, 2023 Diabetic nephropathy (DN) is a common complication of diabetes and a leading cause of end-stage renal disease. Transforming growth factor-β1 (TGF-β1)/SMAD signaling activation plays an important role in the onset and progression of DN.
Chen, Haiyong +4 more
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