【目的】 研究高糖诱导肾小管上皮细胞肥大的作用途径及可能机制65377;【方法】 HK-2细胞分正常对照组(培养基含葡萄糖1 g/L),等渗对照组(葡萄糖1 g/L + 甘露醇3.5 g/L)和高糖组(葡萄糖4.5 g/L)培养65377;收集各组培养至24 h,48 h,96 h的细胞,检测结缔组织生长因子(CTGF)65380;p27kip的mRNA水平65380;CTGF65380;p27kip的蛋白水平65380;细胞增殖活力65380;细胞周期分布及细胞总蛋白含量65377 ...
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[<i>Danzhi Jiangtang</i> Capsule improves renal vascular endothelial function in rats with diabetic nephropathy by downregulating the Notch1/NICD/MAML1 signaling pathway]. [PDF]
Zhu S +7 more
europepmc +1 more source
[Ultra-early administration of eculizumab in a child with atypical hemolytic uremic syndrome: a case report]. [PDF]
Guo DD +4 more
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[<i>Shenqi Xiezhuo</i> Decoction alleviates renal fibrosis in rats by ameliorating oxidative stress and inflammation through the Rap1/MAPK/FoxO3a signaling pathway]. [PDF]
Lu X +6 more
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[<i>Qihuang Jianpi Zishen</i> Granules improves renal damage in MRL/lpr mice by inhibiting B cell differentiation <i>via</i> the AIM2/Blimp-1/Bcl-6 axis]. [PDF]
Cheng L +6 more
europepmc +1 more source
[POEMS syndrome misdiagnosed as systemic sclerosis: A case report]. [PDF]
Liang J, Zhang X, Yao H.
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利多卡因对脂多糖诱导的HK-2细胞炎症反应及TLR4/NF-κB通路的影响
目的 探讨利多卡因对脂多糖(lipopolysaccharide, LPS)诱导的脓毒症肾损伤的保护作用及机制。方法 将肾小管上皮细胞(HK-2)分为空白对照组、LPS组和LPS+利多卡因组。细胞增殖与毒性试剂(cell counting kit-8,CCK-8)法检测细胞增殖活性,采用酶联免疫吸附试验(ELISA)检测各组HK-2细胞炎症因子高迁移率族蛋白B1(high mobility group protein B1,HMGB1)、白细胞介素-6(interleukin-6,IL-6 ...
李青青 +3 more
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[Dietary secoisolariciresinol diglucoside alleviates chronic kidney disease in offspring rats caused by maternal trans-fatty acid exposure by regulating the Bcl-2/Bax/caspase-3 signaling axis]. [PDF]
Ma S, Chen M, Wu T, Zhao W.
europepmc +1 more source
[Systemic lupus erythematosus complicated by autoimmune nodopathy: A case report]. [PDF]
Wei C, Yang Y, Zhao X, Liu X, Jia Y.
europepmc +1 more source
[Palbociclib induces cell cycle arrest and senescence of human renal tubular epithelial cells in vitro]. [PDF]
Huang L, Shen Y, Liu C, Li C, Wang J.
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