Protective Effect of Freeze-Dried Fruit Powder of Phyllanthus emblica L. on Acute and Chronic Hyperuricemia and Liver and Kidney Injuries in Mice [PDF]
, 2023 Objective: To explore the protective effect of the freeze-dried fruit powder of Phyllanthus emblica L. (PEFP) against acute and chronic hyperuricemia (HUA) and liver and kidney injuries in mice.
LI Ruiting, HE Wei, SONG He, XIE Xiaoting, WU Jie, JIANG Yan
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Application status of cell models in clinical nutrition research [PDF]
, 2020 Traditional clinical nutrition research mostly stay at the stage of human and animal experiments. Cell model experiment has gradually become an important way in clinical nutrition research nowadays.
Jian HUANG +4 more
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Renal Protective Effects of Lanzhou Lily (Lilium davidii var. unicolor) Polysaccharide and Aerobic Exercise in Streptozotocin-Induced Diabetic Rats [PDF]
, 2023 objective: To investigate the protective effect of Lanzhou lily polysaccharide (LLP) and aerobic exercise (AE) on the kidney in a rat model of diabetic mellitus (DM).
LI Shouhan, GAO Wenfeng, CUI Zhijia
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泽黄颗粒及其拆方对糖尿病大鼠肾脏AQP1表达的调节效应 [PDF]
Objective: To observe the relationship between the expression of aquaporin-1 (AQP1) and the abnormal fluid metabolism in diabetic nephropathy rats and to explore the preventive and therapeutic mechanism of Zehuang Granule and its disassembled ...
Guo, Liang-feng +8 more
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Study on the protective effect of mitochonic acid-5 on septic acute kidney injury and the underlying mechanism [PDF]
目的探讨线粒体酸5（mitochonic acid-5，MA-5）是否可以减轻脂多糖（lipopolysaccharide，LPS）诱导的脓毒症急性肾损伤以及可能的机制。方法细胞实验：将肾小管细胞分为正常组、MA-5（10 µmol/L）组、LPS（10 mg/L）刺激组和LPS+MA-5治疗组，通过细胞计数试剂盒8法评估细胞活力、流式细胞术评估细胞凋亡率；活性氧（reactive oxygen species，ROS）检测试剂盒检测ROS含量；三磷酸腺苷（adenosine triphosphate ...
Li Peng-yan, Yan miao, Yang Ding-ping
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The effect of pentosan polysulfate on diabetic nephropathy renal tubular epithelial cells injury through regulating p38 MAPK signaling pathway [PDF]
, 2016 目的：观察戊糖多硫酸钠是否通过调控P38MAPK干预糖尿病肾病肾小管上皮细胞的损伤。方法：利用不同浓度（10mmol/L～50mmol/L）葡萄糖刺激肾小管上皮细胞（HK-2）48h，应用CCK-8比色法检测肾小管上皮细胞增殖的改变。利用不同时间段（0h～48h）葡萄糖刺激细胞，用Westernblot法检测P38MAPK蛋白的表达水平。分为正常对照组（control组）、高糖组（HG组，葡萄糖30mmol/L)、戊糖多硫酸钠（PPS）组（PPS200µg/mL)、高糖＋戊糖多硫酸钠组（HG＋
张天英
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, 2007 【目的】探讨白蛋白对近端肾小管上皮细胞（PTCs）增殖与凋亡的影响。【方法】用不同剂量（0．1，0．5，1，5，10，30mg／mL）去脂牛血清白蛋白（dBSA）超载体外培养的NRK52E，dBSA 0mg／mL作为对照。细胞增殖活性用MTS比色法检测和显微镜观察。细胞凋亡检测：荧光染料DAPI染核，DNA梯带实验，原位末端标记（TUNEL）实验和苔盼蓝染色计数。【结果】高剂量dBSA超载未完全融合NRK52E细胞144h后细胞变得更密集。MTS比色结果发现，高剂量dBSA（5、10、30mg／mL ...
孙良忠, 岳智慧, 陈述枚
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Role of tubular cell-derived exosomes in renal ischemia reperfusion injury [PDF]
Renal ischemia reperfusion injury refers to a pathophysiological phenomenon that aggravates the degree of renal injury due to the restoration of blood supply after transient ischemia of renal tissue.
Ai-sha Zhang +7 more
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Association between urinary excretion of protein-bound uremic toxins and upper urinary tract calculus [PDF]
Objective·To investigate the relation between urinary excretion of protein-bound uremic toxins (PBUTs) and upper urinary tract calculus.Methods·Residents aged 18‒80 years in the community of Haitou, Danzhou city in Hainan Province were recruited.
DING Feng +9 more
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Calcitriol relieved kidney fibrosis in 5/6 nephrectomized rats by upregulating Klotho [PDF]
, 2017 摘要 慢性肾脏病（ChronicKidneyDisease，CKD）普遍存在维生素D水平降低情况，并认为维生素D的降低与继发性甲状旁腺功能亢进（secondaryHyperparathyroidismsHPT）及降低骨密度相关。骨化三醇（Calcitriol）作为一种活性维生素D在慢性肾脏病中广泛应用，其能够有效降低iPTH水平。近年来人们发现Calcitriol在抗纤维化的过程中起重要用，本研究主要就Calcitriol能否通过上调抗衰老蛋白Klotho进而延缓肾损伤展开讨论 ...
刘清妍
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