Calcitriol inhibits advanced glycation end product (AGE)-elicited mesangial cell damage by sequestrated RAGE-NF-κB Signaling [PDF]
, 2015 维生素D是通过与骨，甲状旁腺，肾脏和胃肠道的相互作用调节钙稳态，已经被用来作为糖尿病肾病（DKD）的常规用药。几个临床试验表明，维生素D在糖尿病肾病的治疗中，存在着减少蛋白尿和减缓肾损伤的抗炎作用，但其作用机制尚不清楚。而晚期糖化终产物（AGEs）在血浆和肾的积累，在糖尿病肾病中，是大家公认的促炎症分子。为了探索这种抗炎作用，我们设计实验。 研究目的：探寻骨化三醇减少AGEs引起的人肾系膜细胞炎症反应的机制，具体是探寻骨化三醇对AGEs引起的人系膜细胞表达白细胞介素-6（IL-6）和单核细胞趋化因子 ...
刘波
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Advances in the research, diagnosis and treatment of renal cell carcinoma in 2022 [PDF]
, 2023 Renal cell carcinoma (RCC) is one of the three major urinary system tumors. With the changes of lifestyle and the rise of obesity, hypertension and other diseases, the incidence of RCC is increasing.
TIAN Xi, XU Wenhao, ZHU Shuxuan, AIHETAIMUJIANG•Anwaier, SU Jiaqi, YE Shiqi, QU Yuanyuan, SHI Guohai, ZHANG Hailiang, YE Dingwei
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, 1985 血吸虫病常产生肝脏、消化道等器官损害。近十多年来,国外对血吸虫引起的肾脏免疫病理问题,曾进行了某些探讨。国内近年亦有少量血吸虫病免疫学改变的报道,但对血吸虫病性肾病（schistomal nephropathy）却未有系统性报告。本文收集了临床资料较完整的住院血吸虫病547例,尸解者9例,以及动物（家兔）实验性血吸虫病30例（只）资料,分析研究 ...
许乃贵
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The effect of pentosan polysulfate on hyperglycemia stimulated apoptosis HK-2 cell by inhibiting p38MAPK signaling pathway [PDF]
, 2017 目的：研究戊糖多硫酸钠（PPS）通过调控p38MAPK信号通道干预高糖对肾小管上皮细胞（HK-2）损伤的分子机制。 方法：（1）利用含不同浓度（5.5mmol/L、15mmol/L、25mmol/L、30mmol/L）葡萄糖的培养基刺激肾小管上皮细胞（HK-2）48h，再用不用浓度（50μg/mL、100μg/mL、150μg/mL、200μg/mL）戊糖多硫酸钠预处理后的HK-2细胞给予30mmol/L糖浓度的刺激，应用CCK-8比色法检测HK-2细胞生长的改变情况。（2）利用30mmol ...
袁洋
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Research advances Progress in mechanistic studies of renal fibrosis based upon regulatory cell death [PDF]
As a basic pathological feature at advanced stage of various kidney diseases, renal fibrosis (RF) is an important cause of kidney failure. It is characterized by an excessive accumulation of extracellular matrix (ECM), damage of renal tissue structure ...
Guang-ming Yin +5 more
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, 2004 【目的】分析肾活检诊断明确的原发性慢性肾小球肾炎患者尿中修饰型白蛋白可能的病理生理和临床意义。【方法】46例经肾活检诊断明确,并除外狼疮性肾炎、糖尿病肾病、原发性高血压、心脑血管损害的原发性慢性肾小球肾炎患者尿标本,用免疫印记法检测尿白蛋白片断(uAF)的阳性率。【结果】病理损害I级患者uAF阳性率25%,Ⅱ级29%,Ⅲ级60%,Ⅳ级88 ...
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3-Monochloropropane-1,2-diol induced cell apoptosis in HK2 cells via mitochondria-dependent pathway [PDF]
ObjectiveThis study investigated the toxic effects of the food contaminant 3-monochloropropane-1,2-diol (3-MCPD) on the human renal tubular epithelial cell line (HK2) and examined the underlying mechanisms.MethodsCell viability, morphology, mitochondrial
JIN Chengni +4 more
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Epithelial-mesenchymal Transition in Renal Cell Carcinoma: The Role of Hepatocyte Nuclear Factor 4α [PDF]
, 2013 【背景及目的】 肾癌（renalcellcarcinoma，RCC）是起源于肾小管上皮细胞的恶性肿瘤，占肾脏恶性肿瘤的80％~90％，近年来发病率呈上升趋势。除传统手术治疗外，缺乏其它的有效治疗方法。上皮间质转化(epithelial-mesenchymaltransition，EMT)是上皮细胞在细胞结构、形态、功能等方面获得间质细胞特性的过程，在肿瘤的发生、浸润、转移过程中具有重要作用，核心为上皮标志物E-cadherin表达降低和间质标志物表达增高。肝细胞核因子4α ...
谭伟
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Prospects and challenges of selectivity proteinuria index in clinical practices [PDF]
Plasma proteins are selectively filtrated by glomerular filtration membrane due to their sizes and charge barriers. By comparing renal clearance of a larger molecular weight to a smaller molecular weight protein in plasma, selectivity proteinuria index ...
Bing Dai, Qi-liang Chen
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藏药镰形棘豆的化学成分、药理作用及毒理学研究进展 [PDF]
, 2016 目的:为进一步研究和开发利用藏药镰形棘豆提供参考。方法:以"镰形棘豆""莪达夏""化学成分""药理作用""毒理学""Oxytropis""Oxytropis falcata""Oxytropis falcata Bunge""Chemical constituents""Chemical composition""Pharmacologic actions""Toxicology"等为关键词,组合查询2010年1月-2016年2月在Pub Med、中国知网、万方、维普等数据库中的相关文献 ...
刘晓玲 +4 more
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