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Advances in the research, diagnosis and treatment of renal cell carcinoma in 2022 [PDF]
Renal cell carcinoma (RCC) is one of the three major urinary system tumors. With the changes of lifestyle and the rise of obesity, hypertension and other diseases, the incidence of RCC is increasing.
TIAN Xi, XU Wenhao, ZHU Shuxuan, AIHETAIMUJIANG•Anwaier, SU Jiaqi, YE Shiqi, QU Yuanyuan, SHI Guohai, ZHANG Hailiang, YE Dingwei
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Review of the Role of EBUS-TBNA for the Pulmonologist, Including Lung Cancer Staging [PDF]
This review focuses on the role of endobronchial ultrasound-guided transbronchial needle aspiration in day-to-day pulmonology practice. Case examples are given of the common indications for endobronchial ultrasound-guided transbronchial needle aspiration
Alan HODGSON +4 more
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双膦酸盐是用于骨骼疾病及钙代谢性疾病治疗的一类药物,主要用于治疗骨质疏松症、佩吉特病、高钙血症等。同时临床研究显示双膦酸盐还可用于多发性骨髓瘤、乳腺癌、肾癌、前列腺癌等疾病的辅助治疗,改善患者的临床结局,尤其是唑来膦酸盐的抗肿瘤效果更具优势,被广泛应用于多种恶性肿瘤的临床研究。本文就双膦酸盐在肿瘤辅助治疗中的临床研究进展进行综述。国家自然科学基金面上项目 ...
何斌 +4 more
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Effect of lysine demethylase 5C on renal carcinoma metastasis [PDF]
Objective·To investigate the effects of lysine demethylase 5C (KDM5C) on the migration and invasion of renal clear cell carcinoma, analyze the genes regulated by KDM5C and explore the mechanisms of promoting renal cell carcinoma after its inactivation ...
CHEN Ningdai +4 more
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肾细胞癌又名肾癌,约占肾脏恶性疾病的80%-90%,是泌尿系统中发病率仅次于前列腺癌、膀胱癌的恶性肿瘤[1]。肾癌的早期临床症状较为隐匿,发病原因尚未明确[2]。因此寻找到新的生物学标志物对肾癌的诊断、治疗及预后都尤为重要[3]。本文探讨了蛋白质二硫键异构酶A3(PDIA3)在肾癌组织中的表达量,以验证其是否可以成为诊断肾癌的新候选标志物。
杨旭, 崔璨璨, 杨照微, 徐飞
doaj
Characteristics of Cancer Epidemiology among 0-14 years old Chinese Children,2005—2015 [PDF]
BackgroundCancer has become a leading cause of death for Chinese children, imposing a great economic burden on society and families. Therefore, it is extremely important to understand the epidemicsizes and trends of childhood malignancies.ObjectiveTo ...
TANG Hui, GUO Hong, CAO Fang, YAN Yizhong, HE Jia, GUO Heng, CUI Xiaobin, HU Yunhua
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液相色谱-质谱联用技术筛查synemin蛋白及其在肾癌诊断中的作用
目的本研究的目的是利用化学和生物信息学的方法寻找肾癌和癌旁组织的差异蛋白,探讨目标蛋白作为肾癌生物标志物的可能性。方法采用液相色谱-质谱法鉴定肾癌和癌旁组织差异表达的蛋白,借助免疫组织化学的方法观察肾癌和癌旁组织标本中synemin蛋白的表达。结果肾癌与癌旁组织差异表达的蛋白有26个,肾癌组织中过表达18个,低表达8个。synemin蛋白在肾癌组织中的高表达,统计学差异明显 ...
谭文佳 +3 more
doaj
近年来,肾癌的发病率呈现逐年递增的趋势[1],在泌尿系统肿瘤中仅次于前列腺癌和膀胱癌。应用蛋白质组学技术对肾癌组织和癌旁组织中的蛋白进行定性定量研究[2],是寻找肾癌肿瘤标志物的关键。本研究探讨NPM1在肾癌组织中的表达量,为肾癌的早期诊断和筛查提供方向。
崔璨璨, 何成彦, 郭贺, 李晓欧
doaj
肾细胞癌(RCC)又称为肾腺癌,简称肾癌,是肾实质最为常见的一种恶性肿瘤,约占肾脏恶性肿瘤的80%-90%,其发病率约位居泌尿生殖系统肿瘤第二位,且流行病学调查研究显示,肾细胞癌发病率目前正以每年2%的速度增加[1-2]。研究显示,肾癌的发生发展与机体免疫功能有着密切的联系[3]。
宋哲, 周治军
doaj
Epithelial-mesenchymal Transition in Renal Cell Carcinoma: The Role of Hepatocyte Nuclear Factor 4α [PDF]
【背景及目的】 肾癌(renalcellcarcinoma,RCC)是起源于肾小管上皮细胞的恶性肿瘤,占肾脏恶性肿瘤的80%~90%,近年来发病率呈上升趋势。除传统手术治疗外,缺乏其它的有效治疗方法。上皮间质转化(epithelial-mesenchymaltransition,EMT)是上皮细胞在细胞结构、形态、功能等方面获得间质细胞特性的过程,在肿瘤的发生、浸润、转移过程中具有重要作用,核心为上皮标志物E-cadherin表达降低和间质标志物表达增高。肝细胞核因子4α ...
谭伟
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