Results 51 to 60 of about 3,398 (154)
Zhongguo shiyan zhenduanxue, 2011 目的探讨波形蛋白（Vimentin）在肾癌组织中的表达与病理分期、分级及预后的相关性。方法采用免疫组织化学方法检测38例肾癌组织中Vimentin的表达。结果 Vimentin表达阳性率,在肾癌组织中为78.9%,在癌旁组织中为5%,两组比较,差异有统计学意义 ...
孙守田 +5 more
doaj
Screening the Drug Sensitivity Genes Related to GEM and CDDP in the Lung Cancer Cell-lines [PDF]
, 2009 Background and objective Screening of small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) cell lines with gemcitabine hydrochloride (GEM) and cisplatin (CDDP) related to drug sensitivity gene might clarify the action mechanism of anti ...
Chunyu YANG +3 more
core
Zhongguo shiyan zhenduanxue, 2015 目的探讨miR-514在肾细胞癌中的表达变化及其临床意义。方法提取45例肾癌及其癌旁正常组织中的总RNA,逆转录后用实时荧光定量PCR的方法检测miR-514在肾癌组织和癌旁正常组织中的表达情况,并分析其与肾癌患者临床病理特征的关系。结果与相应癌旁组织相比,miR-514在肾癌组织中表达量显著下调,下调率为86.67%。miR-514表达水平与患者年龄、性别、病理分型、TNM分期没有关系,但其表达水平与Fuhrman分级有关。结论 miR-514可能与肾癌的发生发展有密切关系,进行miR ...
杨媛慧 +3 more
doaj
[Treatment and prognosis of multiple primary malignant neoplasms complicated with renal cell carcinoma]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2022 Qiu M +9 more
europepmc +1 more source
肾透明细胞癌Caki-1细胞系差异表达基因的生物信息学分析 [PDF]
, 2018 目的比较肾透明细胞癌Caki-1细胞系与正常肾上皮细胞系ASE-5063中的差异表达基因(DEGs),寻找潜在的肾透明细胞癌特异性分子标志物。方法利用GEO数据库自带的GEO2R在线分析工具分析基因芯片GSE78179,将筛选出的DEGs分别导入Metascape、STRING以及Cytoscape进行综合分析并筛选出核心基因。最后使用Fun Rich等软件对筛选出的核心基因进行GO和KEGG富集分析。结果共筛选出562个DEGs,其中上调基因345个,下调基因217个 ...
朱合欢 +5 more
core
[Establishment of a mutation prediction model for evaluating the efficacy of immunotherapy in renal carcinoma]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2022 Qin CP +9 more
europepmc +1 more source
Mechanisms of PTEN-regulated PDK1 in modulating malignant phenotypes of clear cell renal cell carcinoma [PDF]
Background and purpose: The aberrant activation of pyruvate dehydrogenase kinase 1 (PDK1) drives tumor microenvironment remodeling and metastasis through mediating the Warburg effect.
DUAN Shuangshuang, GULINAIZAIER Abudusaimaiti, ZHANG Lijun, SUN Miao, LIU Huibin
core +1 more source
抗原致敏IL-12基因修饰的树突状细胞诱导抗肾癌免疫的体外研究 [PDF]
, 2007 【目的】探讨肾癌细胞抗原致敏白介素-12（IL-12）基因修饰的树突状细胞（DC）体外诱导、激活细胞毒性T淋巴细胞（CTL）免疫杀伤肾癌细胞的效能及相关免疫机制。【方法】采用重组逆转录病毒介导IL-12基因修饰人外周血单个核细胞（PBMC）来源的DC；超声细胞破碎法提取肾癌细胞粗提抗原（Ag）致敏经IL-12转染的DC；ELISA法检测各组DCs和各组CTLs上清中IL-12、IFN-γ因子的分泌水平；流式细胞仪（FACS）分析各组DCs表面CD83、CD86、HLA-DR的表达 ...
张珑涓 +5 more
core
, 2017 作为2型糖尿病的一线用药—二甲双胍,其作用被不断地挖掘,近年来科学家们发现二甲双胍不仅改善胰岛素抵抗(IR),还具有抗癌、抗炎、抗血栓形成、抗衰老等功效;其治疗的适应症不再局限于糖尿病,在肿瘤、甲状腺疾病、哮喘、心血管疾病、神经退行性病等领域上也开辟了新的疆土;现就关于二甲双胍对肿瘤、甲状腺疾病 ...
杨叔禹, 苏伟娟, 苏美梅
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Innovations and Challenges in Molecular Probe-Based Precision Theranostics for Genitourinary System Tumors [PDF]
Genitourinary system tumors, as a major clinical challenge posing a serious threat to human health, urgently require breakthroughs in the construction of a precision diagnosis and treatment system.
Mingwei SUN, Pengyu GUO, Wanhai XU
core +1 more source