Results 1 to 10 of about 5,461 (153)
A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化
Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023 Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh +3 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023 Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho +7 more
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 3, Page 192-204, March 2022., 2022 Highlights Many proinflammatory cytokines could be decreased after 1 week of intensive insulin therapy using continuous subcutaneous insulin infusion (CSII). This was the first report showing that the cytokines of interleukin‐6 receptor (IL‐6R), tissue inhibitor of metalloproteinase‐2 (TIMP‐2), platelet‐derived growth factor type BB (PDGF‐BB), and ...
Junyu He +6 more
wiley +1 more source
Veterinary Dermatology, Volume 31, Issue 2, Page 154-e30, April 2020., 2020 Background Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. Hypothesis To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions.
Iva Cvitas +4 more
wiley +1 more source
Interleukin-8 and tumor necrosis factor-α levels in vitreous samples from patients with diabetic retinopathy [PDF]
, 2013 AIM: To measure the interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)levels in vitreous samples obtained the patients undergoing pars plana vitrectomy(PPV)due to diabetic retinopathy(DR), then to compare these results with those of the control group ...
Alper Sengul +7 more
core +1 more source
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929 [PDF]
, 2015 Clnk/MIST在一系列细胞因子依赖的造血细胞系中表达，同时也在一些细胞因子非依赖的肥大细胞系中表达，并且能够与PLC，Grb2，ADAP和HPK-1等蛋白相互作用。 作为Blnk/SLP-76接头分子蛋白家族的第三个成员，Clnk参与免疫受体信号通路的正向调控。但是，在Clnk基因敲除鼠中，Clnk对T细胞，NK细胞和肥大细胞的正常分化和发育并不是必须的。 本论文发现了Clnk在免疫信号通路之外的一些功能。我们发现Clnk在一系列细胞因子非依赖的非造血细胞系中表达，比如L929 ...
徐盟
core +1 more source
The role of Rip3-mediated necrosis in system inflammatory response syndrome [PDF]
, 2016 肿瘤坏死因子-α可以诱导小鼠发生全身免疫反应综合征，其过程中发生了各组织器官的坏死和一系列级联免疫反应。在肿瘤坏死因子-α的作用下，组织细胞中的受体相互作用蛋白3被激活并募集坏死小体，导致细胞坏死，引起周围组织的炎症反应。同时，肿瘤坏死因子-α本身作为促炎因子扩大了机体免疫反应的范围。在肿瘤坏死因子-α诱导的全身免疫反应综合征中，盲肠首先表现出损伤，并且这种损伤可以被Rip3基因敲除所抑制。本论文通过建立小鼠盲肠切除术模型，与肿瘤坏死因子-α诱导全身免疫反应综合征模型并用 ...
李旸欣
core
TNF induced RIP3-dependent NADH depletion [PDF]
, 2015 肿瘤坏死因子（tumornecrosisfactor，TNF）能诱导L929细胞产生相互作用蛋白3（receptor-interactingprotein3，RIP3）依赖的程序性细胞坏死，并且在该过程中，胞内的线粒体产生的活性氧（reactiveoxygenspecies，ROS）会积聚，同时当RIP3的表达水平敲低时，胞内ROS的积聚也受到了抑制。但是RIP3如何影响ROS的具体机制仍不清楚。 因为ROS的产生主要在线粒体电子传递链上，而还原型辅酶Ⅰ（NADH）和还原型辅酶Ⅱ（NADPH ...
张丽芳
core
Study on the relationship between apoptosis and autophagy in prostate epithelial cells under androgen deprivation [PDF]
, 2016 实验目的：本实验为研究剥夺雄激素条件下前列腺上皮细胞系BPH-1细胞凋亡与细胞自噬的相互关系、Beclin-1及其裂解片段与细胞凋亡过程的关系，验证在剥夺雄激素的同时抑制细胞自噬是否能够显著的提高BPH-1细胞的凋亡水平。 研究方法：BPH-1细胞传代过夜更换剥夺雄激素培养基培养0、4、8、12、16、20、24小时后提取总蛋白，westernblot检测LC3-II蛋白的表达评价早期细胞自噬水平的变化。剥夺雄激素培养基培养0、4、8、12、24、36、48小时后提取总蛋白 ...
李剑
core
The Molecular Mechanism of Honokiol Inhibits TNFα /Nur77 Survival Pathway [PDF]
, 2012 在许多肿瘤组织中，肿瘤坏死因子α能够促进肿瘤细胞生存和增殖。通常，在肿瘤微环境中肿瘤坏死因子α的主要来源是多种定向分化的巨噬细胞，而肿瘤坏死因子α可以激活NF-κB以及MAPK等信号通路促进肿瘤细胞的生存。本文研究核受体Nur77在肿瘤坏死因子α相关的生存通路中的作用及和厚朴酚通过下调核受体Nur77蛋白水平抑制肿瘤坏死因子α介导的生存通路。 依据天然产物和厚朴酚治疗各种疾病的多效性，抑制肿瘤细胞增殖的高效性及治疗癌症的临床数据 ...
谢雷
core