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本文报告用放射免疫学方法测定绝经后正常卵巢与卵巢非性腺间质肿瘤患者的卵巢静脉血及外周血中的雌二醇(Estradiol-17β,简称E2)、孕酮(Progesterone,简称P)、睾酮(Tcstosterone,简称T及雄烯二酮(Androstenedione,简称A)的浓度,结果提示;绝经后卵巢非性腺间质肿瘤亦能分泌性激素;肿瘤的内分泌功能与肿瘤的大小在一定范围内无显著相关;卵巢静脉血中的T、A浓度明显升高,可以考虑作为卵巢肿瘤早期诊断的标记物。
doaj +2 more sources
Canine melanocytes: Immunohistochemical expression of melanocytic markers in different somatic areas
Background – Melanoblasts originate in the neural crest from where they migrate to peripheral tissues and differentiate into melanocytes. Alteration during melanocyte development and life can cause different diseases, ranging from pigmentary disorders and decreased visual and auditory functions, to tumours such as melanoma.
Ilaria Porcellato +5 more
wiley +1 more source
Highlights Leukocyte telomere length was independently associated with the risk of cardiovascular mortality. Leukocyte telomere length was not associated with the risk of all‐cause mortality in patients with diabetes. Telomere length may be a predictor of cardiovascular mortality in diabetes.
Ziwei Chen +6 more
wiley +1 more source
Effect of type 2 diabetes on A disintegrin and metalloprotease 10 2型糖尿病对解整合素金属蛋白酶10表达的影响
Highlights a disintegrin and metalloprotease 10 (ADAM10), a sheddase responsible for the cleavage of a variety of cell surface molecules, has been implicated in the pathogenesis of Alzheimer disease, atherosclerosis, and inflammatory and neoplastic disorders, and systemic ADAM10 concentration may potentially be used as a prognostic biomarker. Our study
Sum Lam +3 more
wiley +1 more source
目的 本国际临床指南由欧洲残疾儿童学会(the European Academy of Childhood Disability,EACD)牵头制定,旨在解决发育性协调障碍(developmental coordination disorder,DCD)的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题,通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础,以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类,最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
HDST 技术应用于卵巢癌新辅助化疗中的效果分析 [PDF]
【目的】探讨卵巢癌患者新辅助化疗效果以及在卵巢癌常用化疗方案筛选中应用 HDST 技术的可行性。【方法】回顾性分析于中山大学孙逸仙纪念医院妇科肿瘤专科收治的 11 例按照 NCCN 指南推荐的行新辅助化疗的晚期卵巢癌患者,采集其社会人口学、临床资料及组织标本,并应用HDST 技术进行药敏检测。按照HDST 药敏结果进行分组,比较组间CA125、HE4 与Fagotti 评分指标总下降率的差异,探讨HDST 结果与患者肿瘤指标下降率的关系。【结果】HDST 结果显示6 例患者对选用的铂类药(顺铂或卡铂 ...
何远桥 +7 more
core
膀胱癌是泌尿系统最常见的肿瘤之一,当前膀胱镜检查加病理活检是确诊和随访观察治疗后肿瘤复发进展的金标准,但该检查技术有创且存在有时因尿道狭窄、肿瘤出血致视野不清、取材不充分而影响判断等缺点。因此开发能媲美于膀胱镜检查的无创诊断方法一直是研究者们关注的热点。本文通过文献检索分析归纳总结近10年关于膀胱癌尿液无创诊断研究现状 ...
陈炜
core
MRI and CT Manifestation and Clinical Features of Ovarian Sertoli-Leydig Cell Tumor [PDF]
Objective: To summarize the imaging and clinical features of ovarian Sertoli–Leydig cell tumors (SLCT) to improve our understanding of the disease. Methods: The clinical and imaging data of 15 patients with SLCT confirmed by surgery and pathology were ...
Keyang WANG +4 more
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Preparation of monoclonal antibodies against mouse alpha-fetoprotein and preliminary study on their application [PDF]
原发性肝癌是我国高发的恶性肿瘤之一,每年新发和死亡患者均占全球总数的一半以上。根据全国肿瘤登记中心最新公布的2015年《肿瘤登记年报》数据,我国肝癌新增病例为46.61万,占所有恶性肿瘤的第4位(10.86%),而死亡病例为42.21万,占所有癌症死亡的第3位(15.00%),仅次于肺癌和胃癌。尽管近年来肝癌的诊断和治疗有了一定的进展,其预后仍然不理想,五年生存率极低。究其原因,大部分肝癌患者往往在疾病的晚期才被诊断出来,有些甚至发生了远端转移,因而错过了最佳治疗时机;此外 ...
潘海娇
core
Studies on the bio-markers of esophageal cancer [PDF]
食管癌是最常见的肿瘤之一,在全世界许多国家都是一种主要的肿瘤致死因素。目前对食管癌的确诊方法可分为:早期诊断和临床诊断两大类。临床诊断即上消化道造影及内镜检查,早期诊断指在出现症状前的诊断。目前食管癌早期诊断的方法主要还是食管拉网﹑内腔镜活体染色,但是其灵敏度和特异性都不是很理想。比较临床上对食管癌早期诊断的几种方法,分子生物学诊断技术中的肿瘤标记物检测是一种比较便捷、灵敏、特异的手段。; 肿瘤标记物是指那些能够反映恶性肿瘤细胞已经发展到那个阶段的能被检测到的特征性生物活性物质 ...
谢洪宝
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