Results 11 to 20 of about 933 (99)

Glycosylated fibronectin improves first‐trimester prediction of pre‐eclampsia

Ultrasound in Obstetrics &Gynecology, Volume 62, Issue 4, Page 512-521, October 2023., 2023
ABSTRACT Objective To determine whether maternal serum glycosylated fibronectin (GlyFn) level in the first trimester increases the sensitivity of the Fetal Medicine Foundation (FMF) triple test, which incorporates mean arterial pressure, uterine artery pulsatility index and placental growth factor, when screening for pre‐eclampsia (PE) in an Asian ...
S. Moungmaithong, X. Wang, C. S. L. Lau, A. W. T. Tse, N. M. W. Lee, H. H. Y. Leung, L. C. Poon, D. S. Sahota   +7 more
wiley   +1 more source

Routine first‐trimester pre‐eclampsia screening and risk of preterm birth

Ultrasound in Obstetrics &Gynecology, Volume 60, Issue 2, Page 185-191, August 2022., 2022
Abstract Objectives Preterm birth (PTB) is a major public health problem worldwide. It can occur spontaneously or be medically indicated for obstetric complications, such as pre‐eclampsia (PE) or fetal growth restriction. The main objective of this study was to investigate whether there is a shared uteroplacental etiology in the first trimester of ...
V. Giorgione, O. Quintero Mendez, A. Pinas, W. Ansley, B. Thilaganathan   +4 more
wiley   +1 more source

International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation

Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019
目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua, Wenchong Du, Xiaotian Dai, Meiqin Wu, Xianying Cai, Min Shen, Liping Zhu   +6 more
wiley   +1 more source

Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy

Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 5, Page 641-648, November 2025.
ABSTRACT Objective To evaluate the impact of low‐dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA‐PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early‐onset pre‐eclampsia (PE).
C. Trilla, J. Platero, J. Mora, M. N. Nan, C. Medina, O. Alejos, J. Parra, E. Llurba   +7 more
wiley   +1 more source

Placental biomarker and fetoplacental Doppler abnormalities are strongly associated with placental pathology in pregnancies with small‐for‐gestational‐age fetus: prospective study

Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 6, Page 749-760, June 2025.
ABSTRACT Objective Placental dysfunction can result in small‐for‐gestational age (SGA) or fetal growth restriction (FGR). The aim of this prospective cohort study was to assess the association of the cerebroplacental ratio (CPR) and other more conventional fetoplacental Doppler indices, circulating placental growth factor (PlGF) levels and soluble fms ...
J. Hong, K. Crawford, E. Cavanagh, V. Clifton, F. da Silva Costa, A. V. Perkins, S. Kumar   +6 more
wiley   +1 more source

冠状动脉易损斑块相关炎性因子的研究进展 [PDF]

, 2012
炎症在动脉粥样硬化(AS)中扮演重要的角色。炎症贯穿于疾病发生、发展的各个阶段,包括易损粥样斑块形成和最终的破裂。其过程涉及许多炎性细胞,如单核细胞源性巨噬细胞、T淋巴细胞及其合成和分泌的细胞因子、趋化因子和酶。这些炎性因子导致内皮细胞活化,平滑肌细胞增殖,纤维帽基质的降解而形成易损斑块。这些有关炎性因子通过各种方法可从外周血检测到,且循环血液中的炎症因子浓度与将来的心血管事件的发生密切相关 ...
王焱, 袁平年
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Screening for pre‐eclampsia using pregnancy‐associated plasma protein‐A or placental growth factor measurements in blood samples collected at 8–14 weeks' gestation

Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 5, Page 567-574, May 2025.
ABSTRACT Objectives To assess the value of pregnancy‐associated plasma protein‐A (PAPP‐A) in screening for preterm pre‐eclampsia (PE) (delivery < 37 weeks' gestation) measured in maternal blood samples collected before 11 weeks, and to compare the screening performance of PAPP‐A with that of placental growth factor (PlGF) from blood samples collected ...
L. Rode, A. Wright, D. Wright, M. Overgaard, L. Sperling, P. Sandager, P. Nørgaard, F. S. Jørgensen, H. Zingenberg, I. Riishede, A. Tabor, C. K. Ekelund, the PRESIDE Study Group, M. R. Andersen, L. Bathum, C. A. Juel Jensen, C. S. Knudsen, N. G. Pedersen, K. Pihl, C. Vedel, H. Skov, S. R. Wagner   +21 more
wiley   +1 more source

Selective thrombosis in tumor vessels induced by fusion proteins SP5.2/tTF [PDF]

, 2009
选择性肿瘤组织血管栓塞是一种很有前景的抗肿瘤策略。tTF（truncatedtissuefactor，tTF）是TF（tissuefactor）胞外的一部分，当tTF融合蛋白由靶向片段定位到血管时，可以诱发肿瘤组织血管栓塞，阻断肿瘤营养物质和氧气的供给，引发肿瘤缺血性坏死，从而达到抗肿瘤作用。 SP5.2是16个氨基酸组成的多肽，对肿瘤血管内皮细胞表面的VEGF受体Flt-1具有良好的选择性，是一种理想的载体。利用SP5.2载体，我们构建一种新的tTF融合蛋白 ...
叶民
core   +1 more source

N‐terminal pro B‐type natriuretic peptide as biomarker to predict pre‐eclampsia and maternal–fetal complications

Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 4, Page 447-455, April 2025.
ABSTRACT Objective A soluble fms‐like tyrosine kinase‐1 (sFlt‐1)‐to‐placental growth factor (PlGF) ratio cut‐off of 38 is currently considered optimal for ruling out pre‐eclampsia (PE); however, implementation of this ratio in clinical practice is limited.
M. N. Nan, C. Garrido‐Giménez, Á. Garcia‐Osuna, P. Garcia Manau, J. Ullmo, J. Mora, O. Sanchez‐Garcia, J. Platero, M. Cruz‐Lemini, E. Llurba, on behalf of the EuroPE working group, M. Vila‐Cortés, M. J. Pelegay, M. Ricart, B. Muñoz‐Abellana, X. Gabaldó Barrios   +15 more
wiley   +1 more source

Characterization of Dll4 Monoclonal Antibody which can block the Dll4-Notch signaling pathway [PDF]

, 2017
1917年，ThomasHuntMorgan在果蝇中首次发现Notch基因，1980年Notch基因首次被克隆出来。Notch信号通路是一条保守而重要的信号转导通路，它对细胞命运的影响非常大，通过相邻细胞之间的相互作用调节细胞分化、增殖和凋亡，在许多至关重要的生理、病理过程中都起着重要作用。Notch信号通路由Notch受体、Notch配体（DSL蛋白）、CSL（CBF-1，Suppressorofhairless，Lag的合称）DNA结合蛋白、其他的效应物和Notch的调节分子等组成 ...
徐哲妮
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