Results 21 to 30 of about 740 (94)
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 4, Page 447-455, April 2025.ABSTRACT Objective A soluble fms‐like tyrosine kinase‐1 (sFlt‐1)‐to‐placental growth factor (PlGF) ratio cut‐off of 38 is currently considered optimal for ruling out pre‐eclampsia (PE); however, implementation of this ratio in clinical practice is limited.
M. N. Nan +15 more
wiley +1 more source
孕妇血清PIGF、sFlt-1及sEng联合使用在预测子痫前期发病中的诊断价值分析
Zhongguo shiyan zhenduanxue, 2018 妊娠期高血压(GH)和子痫前期(PE)属于妊娠期高血压疾病,均在孕20周以后发病,其中PE因病情重且难以准确预测而备受关注,研究表明PE发病的早晚与分娩早晚以及疾病预后有密切的关系,越来越多的证据表明,胎盘促血管形成因子和抗血管形成因子参与了PE的发病。本研究选择促血管形成因子的胎盘生长因子(PlGF)和抗血管形成因子的可溶性血管生长因子受体-1(sFlt1 ...
张翀, 贺锐, 赵翠生, 王红洲
doaj
Prediction of pre‐eclampsia using maternal hemodynamic parameters at 12 + 0 to 15 + 6 weeks
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 2, Page 173-182, February 2025.ABSTRACT Objectives To compare the maternal hemodynamic profile at 12 + 0 to 15 + 6 weeks' gestation in women who subsequently developed pre‐eclampsia (PE) and those who did not, and to assess the screening performance of maternal hemodynamic parameters for PE in combination with the Fetal Medicine Foundation (FMF) triple test, including maternal ...
X. Wang +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的探讨妊娠早期Granulated Metrial Gland（GMG）细胞对血管增生及胎盘形成的作用。方法对非妊娠及妊娠第517天小鼠的子宫标本分别行PAS试剂,抗血管内膜生长因子（VEGF）抗体及抗F-Ⅷ抗体染色,以测定不同时期胎盘组织的面积,其内血管面积及GMG细胞数。通过ELISA和RT-PCR方法测定妊娠期子宫内膜内VEGF的量变。利用双重染色,电镜及免疫电镜方法对产生VEGF的细胞进行鉴定。结果胎盘组织面积在妊娠第814天明显增大,妊娠第13天达到高峰;胎盘内血管面积于妊娠第7天起增大 ...
王春莲 +5 more
doaj
VEGFc promotes corneal angiogenesis in rat through Notch signaling pathway and MMP13 [PDF]
, 2013 正常角膜透明无血管，是眼的最重要屈光介质之一。角膜新生血管的形成是多种局部和全身性疾病所导致的角膜病理性变化，它不仅会使角膜失去透明性，影响视力，甚至致盲，而且会导致角膜移植时发生免疫排斥反应。角膜新生血管形成的确切机制至今尚不清楚。因此，角膜新生血管是眼科医生面临的一个十分棘手的难题，如何治疗新生血管也是当前眼科研究的一个热点。本论文旨在通过对血管内皮生长因子c（VEGFc）激活角膜基质细胞和上皮细胞Notch信号通路及基质金属蛋白酶-13（MMP13）抑制I型胶原产生的研究 ...
马婧
core
Ultrasound in Obstetrics &Gynecology, Volume 64, Issue 5, Page 620-625, November 2024.ABSTRACT Objective To compare the diagnostic performance of different manufacturers' immunoassays for the soluble fms‐like tyrosine kinase‐1 (sFlt‐1)‐to‐placental growth factor (PlGF) ratio with that of a point‐of‐care (PoC) test for glycosylated fibronectin (GlyFn) in women with suspected pre‐eclampsia (PE).
I. Y. M. Wah +7 more
wiley +1 more source
DHX32 promotes angiogenesis in colorectal cancer through augmenting β-catenin signaling to induce expression of VEGFA [PDF]
, 2017 肿瘤的生长和转移离不开肿瘤血管生成，因此抗血管生成是目前肿瘤治疗的重要途径之一，其中血管内皮生长因子VEGF及其信号通路是抗肿瘤治疗的重要靶点。DHX32是近年来新发现的一种RNA螺旋酶，对其在肿瘤发生发展中的作用研究刚刚起步。我们的前期研究表明DHX32在结肠癌中表达上调，并能够促进结肠癌细胞增殖、迁移和侵袭，抑制细胞凋亡；qPCR芯片的筛选结果显示敲低DHX32抑制了血管生成因子VEGFA的mRNA水平，预示着DHX32可能参与了肿瘤血管生成的调控。本研究发现在结肠癌细胞中DHX32通过与b ...
林华月
core
Ultrasound in Obstetrics &Gynecology, Volume 63, Issue 5, Page 605-612, May 2024.ABSTRACT Objective Antenatal growth assessment using ultrasound aims to identify small fetuses that are at higher risk of perinatal morbidity and mortality. This study explored whether the association between suboptimal fetal growth and adverse perinatal outcome varies with different definitions of fetal growth restriction (FGR) and different weight ...
M. Mascherpa +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2012 宫内生长受限（intrauterine growth restriction,IUGR）是胎儿不能完成基因生长潜力的状态,随着胎龄增长,胎儿死亡（IUFD）的可能性也逐渐增长[1]。为了胎儿的安全,母亲需住院治疗[2]。IU-GR传统上被定义为出生体重异常,但是子宫-胎盘循环在IUGF的发展上起了重要的作用,采用多普勒超声分析IUGF是一个有价值的方法 ...
宇雪豹, 倪茗, 范文涛, 何娟
doaj
应用CSC-GE-80基因芯片筛查人子宫内膜早期异位种植的血管生长相关基因 [PDF]
, 2007 【目的】探讨子宫内膜异位早期种植的相关基因,特别是与早期种植相关的血管生长基因。【方法】采用裸鼠人子宫内膜皮下种植的方法,建立裸鼠人子宫内膜异位症模型,在种植后14d,取出成模病灶与未种植内膜进行CSC-GE-80基因芯片筛查比较。【结果】在基因表达谱中最有显著性上调基因50个,最有显著性下调基因47个,包括生长因子和细胞因子及其受体的变化,其中生长因子受体结合蛋白10（growth factor receptor-bound protein10,Grb10）与丁酸盐反应因子1（butyrate ...
何勉 +9 more
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