Results 21 to 30 of about 933 (99)
Prediction of pre‐eclampsia using maternal hemodynamic parameters at 12 + 0 to 15 + 6 weeks
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 2, Page 173-182, February 2025.ABSTRACT Objectives To compare the maternal hemodynamic profile at 12 + 0 to 15 + 6 weeks' gestation in women who subsequently developed pre‐eclampsia (PE) and those who did not, and to assess the screening performance of maternal hemodynamic parameters for PE in combination with the Fetal Medicine Foundation (FMF) triple test, including maternal ...
X. Wang +9 more
wiley +1 more source
孕妇血清PIGF、sFlt-1及sEng联合使用在预测子痫前期发病中的诊断价值分析
Zhongguo shiyan zhenduanxue, 2018 妊娠期高血压(GH)和子痫前期(PE)属于妊娠期高血压疾病,均在孕20周以后发病,其中PE因病情重且难以准确预测而备受关注,研究表明PE发病的早晚与分娩早晚以及疾病预后有密切的关系,越来越多的证据表明,胎盘促血管形成因子和抗血管形成因子参与了PE的发病。本研究选择促血管形成因子的胎盘生长因子(PlGF)和抗血管形成因子的可溶性血管生长因子受体-1(sFlt1 ...
张翀, 贺锐, 赵翠生, 王红洲
doaj
Ultrasound in Obstetrics &Gynecology, Volume 64, Issue 5, Page 620-625, November 2024.ABSTRACT Objective To compare the diagnostic performance of different manufacturers' immunoassays for the soluble fms‐like tyrosine kinase‐1 (sFlt‐1)‐to‐placental growth factor (PlGF) ratio with that of a point‐of‐care (PoC) test for glycosylated fibronectin (GlyFn) in women with suspected pre‐eclampsia (PE).
I. Y. M. Wah +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的探讨妊娠早期Granulated Metrial Gland（GMG）细胞对血管增生及胎盘形成的作用。方法对非妊娠及妊娠第517天小鼠的子宫标本分别行PAS试剂,抗血管内膜生长因子（VEGF）抗体及抗F-Ⅷ抗体染色,以测定不同时期胎盘组织的面积,其内血管面积及GMG细胞数。通过ELISA和RT-PCR方法测定妊娠期子宫内膜内VEGF的量变。利用双重染色,电镜及免疫电镜方法对产生VEGF的细胞进行鉴定。结果胎盘组织面积在妊娠第814天明显增大,妊娠第13天达到高峰;胎盘内血管面积于妊娠第7天起增大 ...
王春莲 +5 more
doaj
VEGFc promotes corneal angiogenesis in rat through Notch signaling pathway and MMP13 [PDF]
, 2013 正常角膜透明无血管，是眼的最重要屈光介质之一。角膜新生血管的形成是多种局部和全身性疾病所导致的角膜病理性变化，它不仅会使角膜失去透明性，影响视力，甚至致盲，而且会导致角膜移植时发生免疫排斥反应。角膜新生血管形成的确切机制至今尚不清楚。因此，角膜新生血管是眼科医生面临的一个十分棘手的难题，如何治疗新生血管也是当前眼科研究的一个热点。本论文旨在通过对血管内皮生长因子c（VEGFc）激活角膜基质细胞和上皮细胞Notch信号通路及基质金属蛋白酶-13（MMP13）抑制I型胶原产生的研究 ...
马婧
core
Ultrasound in Obstetrics &Gynecology, Volume 63, Issue 5, Page 605-612, May 2024.ABSTRACT Objective Antenatal growth assessment using ultrasound aims to identify small fetuses that are at higher risk of perinatal morbidity and mortality. This study explored whether the association between suboptimal fetal growth and adverse perinatal outcome varies with different definitions of fetal growth restriction (FGR) and different weight ...
M. Mascherpa +6 more
wiley +1 more source
DHX32 promotes angiogenesis in colorectal cancer through augmenting β-catenin signaling to induce expression of VEGFA [PDF]
, 2017 肿瘤的生长和转移离不开肿瘤血管生成，因此抗血管生成是目前肿瘤治疗的重要途径之一，其中血管内皮生长因子VEGF及其信号通路是抗肿瘤治疗的重要靶点。DHX32是近年来新发现的一种RNA螺旋酶，对其在肿瘤发生发展中的作用研究刚刚起步。我们的前期研究表明DHX32在结肠癌中表达上调，并能够促进结肠癌细胞增殖、迁移和侵袭，抑制细胞凋亡；qPCR芯片的筛选结果显示敲低DHX32抑制了血管生成因子VEGFA的mRNA水平，预示着DHX32可能参与了肿瘤血管生成的调控。本研究发现在结肠癌细胞中DHX32通过与b ...
林华月
core
Performance of machine‐learning approach for prediction of pre‐eclampsia in a middle‐income country
Ultrasound in Obstetrics &Gynecology, Volume 63, Issue 3, Page 350-357, March 2024.ABSTRACT Objective Pre‐eclampsia (PE) is a serious complication of pregnancy associated with maternal and fetal morbidity and mortality. As current prediction models have limitations and may not be applicable in resource‐limited settings, we aimed to develop a machine‐learning (ML) algorithm that offers a potential solution for developing accurate and ...
J. Torres‐Torres +10 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2012 宫内生长受限（intrauterine growth restriction,IUGR）是胎儿不能完成基因生长潜力的状态,随着胎龄增长,胎儿死亡（IUFD）的可能性也逐渐增长[1]。为了胎儿的安全,母亲需住院治疗[2]。IU-GR传统上被定义为出生体重异常,但是子宫-胎盘循环在IUGF的发展上起了重要的作用,采用多普勒超声分析IUGF是一个有价值的方法 ...
宇雪豹, 倪茗, 范文涛, 何娟
doaj
妊高症患者联合检测血清ACA、抗β2GPⅠ及脂代谢水平的临床意义
Zhongguo shiyan zhenduanxue, 2020 目的通过联合检测血清抗心磷脂抗体(ACA)、抗β2糖蛋白Ⅰ抗体(抗β2GPⅠ)及脂代谢(TC、TG、LDL、HDL、ApoA1和ApoB)的水平,探讨其表达水平对不同发病程度妊高症结局的影响。方法将我院产科收治并诊断为妊娠期高血压的孕妇200例作为实验组,依据发病程度又分为轻度子痫前期组70例、重度子痫前期组70例和子痫组60例;同期住院分娩的正常孕妇80例作为对照组。采用Epoch酶标仪和HITACHI全自动生化分析仪检测以上4组受试对象的血清学及脂代谢指标,评估4组受试者血清ACA ...
李介岩, 李晓丽
doaj