Results 31 to 40 of about 740 (94)
Performance of machine‐learning approach for prediction of pre‐eclampsia in a middle‐income country
Ultrasound in Obstetrics &Gynecology, Volume 63, Issue 3, Page 350-357, March 2024.ABSTRACT Objective Pre‐eclampsia (PE) is a serious complication of pregnancy associated with maternal and fetal morbidity and mortality. As current prediction models have limitations and may not be applicable in resource‐limited settings, we aimed to develop a machine‐learning (ML) algorithm that offers a potential solution for developing accurate and ...
J. Torres‐Torres +10 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2015 目的探讨妊娠期糖尿病小鼠表皮生长因子的表达与发病的关系。方法采用STZ建立妊娠糖尿病小鼠模型,测定母鼠血糖、胎盘系数;ELISA法测定母鼠血清EGF含量,RT-PCR、免疫组化测定GDM组和对照组胎盘EGF的表达。结果 GDM组胎盘系数高于对照组 ...
张梅 +5 more
doaj
妊高症患者联合检测血清ACA、抗β2GPⅠ及脂代谢水平的临床意义
Zhongguo shiyan zhenduanxue, 2020 目的通过联合检测血清抗心磷脂抗体(ACA)、抗β2糖蛋白Ⅰ抗体(抗β2GPⅠ)及脂代谢(TC、TG、LDL、HDL、ApoA1和ApoB)的水平,探讨其表达水平对不同发病程度妊高症结局的影响。方法将我院产科收治并诊断为妊娠期高血压的孕妇200例作为实验组,依据发病程度又分为轻度子痫前期组70例、重度子痫前期组70例和子痫组60例;同期住院分娩的正常孕妇80例作为对照组。采用Epoch酶标仪和HITACHI全自动生化分析仪检测以上4组受试对象的血清学及脂代谢指标,评估4组受试者血清ACA ...
李介岩, 李晓丽
doaj
Progression of Ziv-aflibercept on metastatic colorectal cancer [PDF]
, 2015 针对特异性分子靶点的靶向药物治疗已成为转移性结直肠癌(M CrC)治疗的新方向。2012年zIV-阿柏西普被美国食品和药物管理局批准用于M CrC患者,zIV-阿柏西普是一种作用于血管生成信号通路的重组融合蛋白,通过与血管内皮生长因子(VEgf)受体结合,从而阻断肿瘤的生长和转移。一项Ⅲ期临床研究结果显示zIV-阿柏西普能显著延长M CrC患者的生存期。本文结合国内外最新研究报道,对zIV-阿柏西普治疗M CrC的研究进展作一综述。Targeted drug therapy for specific ...
宋敏
core
野生动物学报, 2018 胚胎发育阶段是指受精卵至胎儿娩出的发育过程,包括分化前期,胚胎阶段和胎儿阶段。PLAC-8基因在胎儿的发育阶段起到连接胎儿和母体的作用。并且是胚胎着床过程中的关键分子。对PLAC-8基因的研究,对预测野生动物的妊娠结果具有至关重要的作用,对于妊娠早期的基因诊断提供了证据。本实验从东北虎胎盘cDNA文库中成功克隆了具有完整编码区的PLAC-8基因的全长cDNA序列,并利用生物信息学方法对其序列进行了结构分析,为进一步研究PLAC-8的生物学功能及其在胎儿发育中的分子调控机理奠定基础。
李 倩, 元虹懿, 杜海荣, 张明海
doaj
Feasibility study on quantifying retinal vascular features for predicting preeclampsia based on artificial intelligence models [PDF]
Objective·To explore the predictive capability of retinal vascular features in preeclampsia (PE) based on artificial intelligence (AI) models.Methods·This retrospective study enrolled 789 pregnant women who registered from June 2020 to January 2021 at ...
HUA Xiaolin +5 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2019 1临床资料患儿,男,生后6h入院。因胎龄29周,生后6h入院,住院号:343233。生后皮肤颜色青紫,反应差,呼吸弱,Apgar评分约7分,体重850g,生后患者家属放弃抢救抱回家,棉被保暖,母亲顺产后因胎盘置入,行子宫全切术。家属于出生后6h抱患者来院要求抢救。查体:体温35℃,脉搏134次/分,呼吸36/次,头围24cm,身长33cm,早产儿貌,反应差,哭声弱,呼吸稍快,面色庆度发绀 ...
尹显贵 +3 more
doaj
Relationship between Doppler ultrasound parameters of uterine artery, umbilical artery, middle cerebral artery and placental vasculopathology and pregnancy outcome in preeclampsia rat model [PDF]
Objective·To measure the parameters of the uterine artery, umbilical artery and middle cerebral artery in a rat model of preeclampsia (PE) by Doppler ultrasound, and compare the pathological changes in placental blood vessels and pregnancy outcomes, in ...
CUI Jianjian +7 more
core +1 more source
Review of positive airway pressure in the treatment of pregnancy with obstructive sleep apnea syndrome [PDF]
Obstructive sleep apnea （OSA） exhibits a high prevalence during pregnancy and serves as an independent risk factor for hypertensive disorders during pregnancy， preeclampsia， and gestational diabetes mellitus. Moreover， it readily leads to various adverse
LIU Xinran, WANG Jingyu, HAN Fang, LIU Guoli
core +1 more source
结合临床与超声影像多模态数据构建小于胎龄儿预测模型 [PDF]
目的探索结合妊娠早期和妊娠中期的临床数据与超声影像多模态数据对小于胎龄儿（SGA）的预测价值，构建和内部验证基于多种机器学习算法的SGA 预测模型。方法本研究回顾性纳入单胎妊娠孕妇1 307例，根据INTERGROWTH-21st胎儿生长标准诊断SGA并采集包括临床一般资料、生化检验数据及产前超声筛查数据的多模态数据。轻度梯度增强算法（XGBoost）用于计算变量重要性，七种机器学习算法用于预测模型的构建与内部验证，受试者工作特性曲线下面积（AUC）作为衡量预测效能的主要指标，结合10 ...
朱云晓, 陈心雨
core +1 more source