Results 21 to 30 of about 1,739 (158)
Journal of Diabetes, Volume 14, Issue 2, Page 97-103, February 2022., 2022 Highlights Vitamin D receptor (VDR) methylation attenuates the association between physical activity and type 2 diabetes mellitus (T2DM). The methylation status of the VDR promoter is associated with the secretion and sensitivity of insulin. A high physical activity level is associated with a decreased risk of T2DM compared to a low physical activity ...
Songcheng Yu +7 more
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022 Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques +4 more
wiley +1 more source
Journal of Diabetes, Volume 12, Issue 5, Page 406-416, May 2020., 2020 Highlights In patients with hypertension and diabetes, early detection and intervention of insulin resistance and related risk factors in patients with normal BMI may reduce the occurrence of urinary microalbumin and delay the progression of CKD. Abstract Background The relationship between albuminuria and insulin resistance (IR) has not been clarified
Shi Gu +4 more
wiley +1 more source
Journal of Diabetes, Volume 11, Issue 12, Page 938-948, December 2019., 2019 Highlights Diabetic kidney disease is a common comorbidity of type 2 diabetes mellitus. In studies investigating the effect of renal function on the efficacy of treatment with glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), these agents improved glycemic control in patients with mild to moderately impaired kidney function, without significant ...
Lance A. Sloan
wiley +1 more source
The relationship between the levels of white blood cell and lipopolysaccharide binding protein and intrahepatic triglyceride content , metabolic abnormalities in obese adults [PDF]
, 2016 研究目的 非酒精性脂肪性肝病（NAFLD）常常伴随炎性因子的增多，且其发生发展与代谢综合征和胰岛素抵抗紧密相关。本研究针对中心性肥胖人群进行横断面数据分析，探讨白细胞（WBC）及脂多糖结合蛋白水平（LBP）与肝脏脂质含量（IHTC）及其相关代谢异常的关系。 研究方法 本研究纳入485名40-65岁中心性肥胖受试者，进行问卷调查包括病史、生活方式等；测定生化指标并进行胰岛功能评估；通过氢质子磁共振波谱（1H-MRS）技术定量分析肝内甘油三酯含量；进行内脏脂肪含量等测定 ...
孙倩
core
Study on the Relationship between Blood Stasis Syndrome and HOMA-IR, Hs-CRP and NIHSS Score of Acute Cerebral Infarction [PDF]
, 2015 摘要 目的：比较急性脑梗死血瘀证与非血瘀证之间胰岛素抵抗、超敏C反应蛋白、NIHSS评分和血脂四项等指标是否有差异性，探讨急性脑梗死血瘀证与胰岛素抵抗、炎症因子及神经功能缺损程度的关系，从而提高对急性脑梗死血瘀证的认识，为临床应用活血化瘀法治疗脑梗死提供理论依据。 方法：选取厦门市中医院脑病科2013年12月至2014年12月期间内明确诊断急性脑梗死的住院患者，按照病例纳入标准选取血瘀证组和非血瘀证组病例各40例，两组分别检测空腹血糖，空腹血清胰岛素，Hs-CRP、血脂四项等相关生化指标 ...
罗艾君
core
Improvement and Mechanism of Ganoderma lucidum Polysaccharides and Its Flora Metabolites on Insulin Resistance in HepG2 Cells [PDF]
, 2023 Objective: To investigate the effects of Ganoderma lucidum polysaccharides and its flora metabolites on the insulin resistance status of HepG2 cells and its mechanisms.
Dongbo LIU +4 more
core +1 more source
明日叶查尔酮对胰岛素抵抗细胞PI3K-Akt-GLUT4信号通路的影响 [PDF]
, 2017 目的研究明日叶查尔酮(Angelica keiskei; chalcones,AC)对胰岛素抵抗L6细胞磷脂酰肌醇3激酶-蛋白激酶-葡萄糖转运体4(PI3K-Akt-GLUT4)信号通路的影响。方法采用; 高浓度胰岛素诱导的胰岛素抵抗L6细胞,分别加入5、10、20 mumol /L终浓度的明日叶查尔酮共同培养24; h,葡萄糖氧化酶法测定细胞上清液中葡萄糖含量,逆转录聚合酶链式反应方法检测细胞PI3K和Akt的mRNA表达水平,蛋白印迹法检测GLUT4和Ak; t的蛋白表达水平 ...
孔杭如 +5 more
core
Zhongguo shiyan zhenduanxue, 1998 胰岛素抵抗与胰岛素抗药性的区别向红丁作者单位：１００７３０北京协和医院胰岛素抵抗是指机体对胰岛素的敏感性下降，一定量的胰岛素不能产生这种量胰岛素所应有的生物学效应。在有胰岛素抵抗的患者体内，内源及外源性胰岛素不能很好地发挥作用，结果可引起高血糖、高血...
向红丁
doaj
Tributyltin and bisphenol A induce polycystic ovarian syndrome and its mechanisms involved [PDF]
, 2015 多囊卵巢综合征（polycysticovariansyndrome,PCOS）是以稀发排卵或无排卵、高雄激素或胰岛素抵抗、多囊卵巢为特征的内分泌紊乱的症候群，复杂且具有异质性，是婚育年龄妇女中最常见的内分泌紊乱疾病。PCOS的病因较为复杂，已有研究证明类雌激素化合物双酚A暴露（bisphenolA,BPA）与PCOS的发病有关，说明环境中的内分泌干扰物与PCOS发病存在一定的联系。 本研究以大鼠为实验动物模型，以三丁基锡（tributyltin,TBT）作为类雄激素化合物的典型代表，探究TBT（10ng/
杨志兵
core