肥胖是一种常见疾病,与瘦素关系密切。瘦素(Leptin),脂肪细胞合成的一种激素,是肥胖基因编码的蛋白质产物,具有广泛的生物学活性,且受体分布广泛,是一种作用于多靶器官、多功能的激素。它可控制能量消耗与食欲,与胰岛素密切相关,多数肥胖个体存在瘦素抵抗且大都存在明显高胰岛素血症。本研究通过对蒙古族、汉族肥胖及非肥胖人群血清瘦素水平、胰岛素水平、血糖的测定,研究蒙古族和汉族肥胖者瘦素水平的差异及与肥胖、胰岛素、
焦雪琴 +4 more
doaj
摘 要: 【目的】 探讨二甲双胍对多囊卵巢综合征(PCOS)大鼠胰岛素敏感性的作用及机制?【方法】 应用脱氢表雄酮制备PCOS大鼠模型20只,随机分为二甲双胍干预组?PCOS组各10只,同批大鼠设为正常对照组10只?干预前后检测大鼠胰岛素抵抗水平,酶法检测肝脏组织甘油三酯含量,Western blot法检测葡萄糖调节蛋白78 (GRP78)?固醇调节元件结合蛋白-1c(SREBP-1c)和磷酸化AMPKa蛋白(P-AMPKa)的表达变化?【结果】 PCOS 组大鼠表现明显胰岛素抵抗,肝脏组织甘油三酯含量?
doaj
[Association between insulin resistance and idiopathic central precocious puberty in girls and the diagnostic value of insulin resistance]. [PDF]
Li JB +8 more
europepmc +1 more source
[Aerobic exercise regulates macrophage polarization and improves insulin resistance in mice: the mediating role of miR-221-3p]. [PDF]
Li N, Zhang L, Guo Q, Zhou Y, Liu C.
europepmc +1 more source
[Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty]. [PDF]
Zhang HR +7 more
europepmc +1 more source
[Progress in the Study of Mechanisms Clinically Relevant to Insulin Resistance and Lung Cancer]. [PDF]
Chen X, Chen P.
europepmc +1 more source
[Mediating role of insulin resistance in the relationship between hypertension and NAFLD and construction of its risk prediction model]. [PDF]
He Y, He H, Cao Y, Wang F.
europepmc +1 more source
[Effects of chronic intermittent hypoxia and reoxygenation on insulin resistance and skeletal muscle miR-27a-3p/PPARγ/IRS1/PI3K/AKT expressions in rats]. [PDF]
Zhou X +7 more
europepmc +1 more source

