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高表达的溶血卵磷脂酰基转移酶4促进胰腺癌细胞增殖的作用 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨溶血卵磷脂酰基转移酶4（LPCAT4）在胰腺癌中的表达水平及其对胰腺癌细胞增殖的影响。方法在本研究中，利用在线数据库LinkedOmics在线分析KRAS突变型与野生型胰腺癌患者差异表达基因，使用阿拉巴马大学伯明翰分校癌症数据分析（UALCAN），桑格生信分析平台（Sangerbox 3.0）和表达谱交互分析2（GEPIA2）分析LPCAT4在胰腺癌组织中的表达情况。使用Kaplan-Meier Plotter数据库探究LPCAT4与胰腺癌患者预后的相关性 ...
卢灏铭 +7 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1986 通过胆管灌流或胰腺浆膜下多点注射,使胰腺组织膨胀而清晰可见。取出胰脏,用剪剪成细小颗粒。用胶原酶及透明质酸酶消化。非胰岛组织被消化破坏,而胰腺仍保存完整。通过反复倾泻的方法,除去溶液中的杂质,然后在显微镜下手工挑选,可获得高纯度胰岛。
王理开
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Zhongshan Daxue xuebao. Yixue kexue ban, 2000 【目的】观察胰岛培养后胸腺内移植对移植物存活时间的影响。【方法】以C57BL/6 小鼠为受体, BALB/c 小鼠为 供体。胸腺内胰岛未培养组分为单纯移植和移植的同时加腹腔内1 次性注射兔抗小鼠胸腺细胞血清(ATS)两组。胸腺内胰 岛培养组分为24 ℃培养后单纯移植和移植时加用ATS 两组。【结果】未培养胰岛单纯胸腺内移植后平均存活期为(19.5 ± 10.1)d, 加用ATS 后, 可延长至100 d 以上, 其中6 只受体(6/ 8)胸腺内移植物长期存活, 并且诱导了受体对供体的特异性无 ...
王国栋, 陈规划
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Zhongshan Daxue xuebao. Yixue kexue ban, 2010 【目的】 探讨胰腺类癌的临床和病理学特点65377;【方法】 对1997年1月1日至2007年12月31日期间手术治疗的8例胰腺类癌临床病理资料(如肿瘤标志物65380;病理免疫组织化学染色65380;伴发其他肿瘤65380;误诊率65380;肿瘤转移率65380;住院死亡率65380;手术根治率等)进行回顾性分析,并结合国内外文献探讨胰腺类癌的临床和病理学特点65377; 【结果】 肿瘤标志物CEA65380;CA19965380;CA12565380;CA72-4在胰腺类癌的表达阳性率分别为0 ...
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Zhongshan Daxue xuebao. Yixue kexue ban, 1995 本文报告应用杂交瘤技术，制备出鼠抗人胰腺癌单克隆抗体（ｍＡｂ）ＹＰＣ３。ＡＢＣ免疫组织化学检查结果表明，ＹＰＣ３ｍＡｂ与３２例被检胰腺癌组织中的２８例（２８／３２），８７．５％有反应，而与１１例正常胰腺组织全部无反应。ＹＰＣ３ｍＡｂ尚与１９种其它肿瘤中的５种（５／１９，２６．３％）和１７种非肿瘤组织中的５种（５／１７，２９．４％）有反应，但多数反应较弱。ＹＰＣ３ｍＡｂ结合抑制性ＥＬＩＳＡ法测定１３７例血清相应抗原含量结果表明，３１例胰腺癌中的１７例（１７／３１，５４．８％）结合抑制率大于６５ ...
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Journal of Diabetes, Volume 15, Issue 5, Page 397-408, May 2023., 2023 Highlights Neprilysin (NEP) inhibitors may lead to beneficial effects through inhibition of NEP, which involves impairment of glucose homeostasis through modulation of insulin resistance and the development of pancreatic β cell dysfunction as observed in type 2 diabetes mellitus.
Faisal Holil AlAnazi +8 more
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Journal of Diabetes, Volume 15, Issue 4, Page 349-361, April 2023., 2023 Highlights This is the first cross‐sectional study of the association between serum IGF2BP3 levels and odds of T2DM in high‐risk Chinese population. Two upregulated (IGF2BP2 and IGF2BP3) and 5 downregulated (METTL3, ALKBH1, YTHDF2, YTHDF3, and HNRNPC) m6A‐related genes could contribute to the occurrence of T2DM.
Xiaoying Wu +11 more
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Is metformin a possible treatment for diabetic neuropathy? 二甲双胍治疗糖尿病周围神经病变——有益还是有害?
Journal of Diabetes, Volume 14, Issue 10, Page 658-669, October 2022., 2022 Highlights Metformin has been shown to alleviate diabetic peripheral neuropathy. The neuroprotective and analgesic effects of metformin are related to the activation of AMPK, the clearance of MGO, and the reduction of insulin resistance and neuroinflamation. AMPK activation is critical for the analgesic effect of metformin.
Juechun Wei +4 more
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Journal of Diabetes, Volume 14, Issue 4, Page 247-260, April 2022., 2022 Highlights Phosphoinositide 3‐kinase (PI3K)/Akt signaling is an emerging promising therapeutic target for diabetes. Modulation of the PI3K/Akt signaling pathway, via protein and peptide‐based biologics, parasite‐derived molecules, plant extracts, or through microRNA interactions, will regulate the processes that determine the function of β‐cells and ...
Inah Camaya +2 more
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Journal of Diabetes, Volume 14, Issue 4, Page 261-270, April 2022., 2022 Highlights New‐onset diabetes and weight losses were common presentation and risk factors of early‐onset PC, which required more attention. Long‐term diabetes and heavy weight loss were risk factors contributing to distant metastases and less radical surgery, which needed to be better treated.
Minglei Ma +5 more
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