APP17肽对糖尿病性脑病大鼠胰岛功能、脂代谢、神经炎症和认知障碍的影响
目的 探讨APP17肽对糖尿病病大鼠血糖、脂质代谢、认知障碍和神经炎症因子的影响。方法 将Wistar大鼠分为对照组、模型组(DE组)和低、高剂量实验组。除对照组外,各组采用链脲佐菌素诱导Ⅰ型糖尿病脑病大鼠模型。造模成功后,低和高剂量实验组分别灌胃给予0.05μg/kg和0.15μg/kg的APP17肽,对照组和模型组均灌胃等量0.9%NaCl,每天1次,连续灌胃2周。检测大鼠的血糖及糖耐水平;水迷宫实验分析各组认知障碍;酶联免疫吸附试验检测血清脂代谢和炎症因子TNF-a及IL-10;Western ...
刘丽君, 王睿君, 苗燕平
doaj
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